Perfil (CV) del personal docente investigador

Abián Franco, Olga María
Departamento: Departamento de Bioquímica y Biología Molecular y Celular
Área: Bioquímica y Biología Molecular
Centro: Facultad de Ciencias

Research Institutes: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)
INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
Categoría profesional: Prof. Titular Univ.

Cargos
  • Coordinadora del Máster Universitario en Biofísica y Biotecnología Cuantitativa
ORCID: 0000-0001-5664-1729

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Artículos

  • Hermoso-Durán, Sonia; Fraunhoffer, Nicolas; Millastre-Bocos, Judith; Sanchez-Gracia, Oscar; Garrido, Pablo F.; Vega, Sonia; Lanas, Ángel; Iovanna, Juan; Velázquez-Campoy, Adrián; Abian, Olga. Development of a Machine-Learning Model for Diagnosis of Pancreatic Cancer from Serum Samples Analyzed by Thermal Liquid Biopsy. ADVANCED INTELLIGENT SYSTEMS. 2024. DOI: 10.1002/aisy.202400308

  • Ortega-Alarcón, David; Claveria-Gimeno, Rafael; Vega, Sonia; Kalani, Ladan; Jorge-Torres, Olga c; Esteller, Manel; Ausio, Juan; Abian, Olga; Velázquez-Campoy, Adrián. Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2. NUCLEIC ACIDS RESEARCH. 2024. DOI: 10.1093/nar/gkae051

  • Araujo-Abad, Salome; Rizzuti, Bruno; Vidal, Miguel; Abian, Olga; Fárez-Vidal, María Esther; Velázquez-Campoy, Adrián; de Juan Romero, Camino; Neira, José L. Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP. BIOMOLECULES. 2024. DOI: 10.3390/biom14050561

  • Peralta-Moreno, M. N; Mena, Y.; Ortega-Alarcon, D.; Jiménez-Alesanco, A. ; Vega, S.; Abian, O.; Velázquez-Campoy, A.; Thomson, T. M.; Pinto, M.; Granadino-Roldán, J. M.; Tomás, M.; Pérez, J. J.; Rubio-Martínez, J. Shedding Light on Dark Chemical Matter: The Discovery of a SARS-CoV-2 Mpro Main Protease Inhibitor through Intensive Virtual Screening and In Vitro Evaluation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. DOI: 10.3390/ijms25116119

  • Neira, José L.; Rizzuti, Bruno; Abian, Olga; Velazquez-Campoy, Adrian. Isolated auto-citrullinated regions of PADI4 associate to the intact protein without altering their disordered conformation. BIOPHYSICAL CHEMISTRY. 2024. DOI: 10.1016/j.bpc.2024.107288

  • Araujo-Abad, Salome; Rizzuti, Bruno; Soto-Conde, Lourdes; Vidal, Miguel; Abian, Olga; Velazquez-Campoy, Adrian; Neira, José L.; de Juan Romero, Camino. Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024. DOI: 10.1016/j.ijbiomac.2024.133163

  • Araujo-Abad, Salomé; Fuentes-Baile, María; Rizzuti, Bruno; Bazán, J. Fernando; Villamarin-Ortiz, Adrián; Saceda, Miguel; Fernández, Eduardo; Vidal, Miguel; Abian, Olga; Velázquez-Campoy, Adrián; Juan Romero, Camino De; Neira, José L. The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PADI4 in cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023. DOI: 10.1016/j.ijbiomac.2023.125632

  • Navarro, Francesc; Hamri, Salha; Reches, Rosa; Viñas, Miquel; Jahani, Daniel; Ginard, Jaume; Vilardell, Josep; Abián, Olga; Pujol, M. Dolors. Convenient synthesis of ellagic acid from methyl gallate and SARS-CoV-2 3CLpro antiviral activity. SYNTHESIS-STUTTGART. 2023. DOI: 10.1055/a-1941-1437

  • Abian, Olga; Vega, Sonia; Velazquez-Campoy, Adrian. Biological Calorimetry: Old Friend, New Insights. BIOPHYSICA. 2023. DOI: 10.3390/biophysica3010002

  • Campa, Daniele; Gentiluomo, Manuel; Stein, Angelika; Aoki, Mateus Nóbrega; Oliverius, Martin; Vodicková, Ludmila; Jamroziak, Krzysztof; Theodoropoulos, George; Pasquali, Claudio; Greenhalf, William; Arcidiacono, Paolo Giorgio; Uzunoglu, Faik; Pezzilli, Raffaele; Luchini, Claudio; Puzzono, Marta; Loos, Martin; Giaccherini, Matteo; Katzke, Verena; Mambrini, Andrea; Kiudeliene, Edita; Federico, Kauffmann Emanuele; Johansen, Julia; Hussein, Tamás; Mohelnikova-Duchonova, Beatrice; Van Eijck, Casper H.J.; Brenner, Hermann; Farinella, Riccardo; Pérez, Juan Sainz; Lovecek, Martin; Büchler, Markus W.; Hlavac, Viktor; Izbicki, Jakob R.; Hackert, Thilo; Chammas, Roger; Zerbi, Alessandro; Lawlor, Rita; Felici, Alessio; Götz, Mara; Capurso, Gabriele; Ginocchi, Laura; Gazouli, Maria; Kupcinskas, Juozas; Cavestro, Giulia Martina; Vodicka, Pavel; Moz, Stefania; Neoptolemos, John P.; Kunovsky, Lumir; Bojesen, Stig E.; Carrara, Silvia; Gioffreda, Domenica; Morkunas, Egidijus; Abian, Olga; Bunduc, Stefania; Basso, Daniela; Boggi, Ugo; Wlodarczyk, Barbara; Szentesi, Andrea; Vanella, Giuseppe; Chen, Inna; Bijlsma, Maarten F.; Kiudelis, Vytautas; Landi, Stefano; Schöttker, Ben; Corradi, Chiara; Giese, Nathalia; Kaaks, Rudolf; Peduzzi, Giulia; Hegyi, Péter; Morelli, Luca; Furbetta, Niccolò; Soucek, Pavel; Latiano, Anna; Talar-Wojnarowska, Renata; Lindgaard, Sidsel C.; Dijk, Frederike; Milanetto, Anna Caterina; Tavano, Francesca; Cervena, Klara; Eross, Bálint; Testoni, Sabrina G.; Verhagen-Oldenampsen, Judith H.E.; Malecka-Wojciesko, Ewa; Costello, Eithne; Salvia, Roberto; Maiello, Evaristo; Ermini, Stefano; Sperti, Cosimo; Holleczek, Bernd; Perri, Francesco; Skieceviciene, Jurgita; Archibugi, Livia; Lucchesi, Maurizio; Rizzato, Cosmeri; Canzian, Federico. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2023. DOI: 10.1016/j.critrevonc.2023.104020

  • Peralta-Moreno, M. N.; Antón-Muñoz, V.; Ortega-Alarcón, D.; Jiménez-Alesanco, A.; Vega, S.; Abian, O.; Velázquez-Campoy, A.; Thomson, T. M.; Granadino-Roldán, J. M.; Machicado, C.; Rubio-Martínez, J. Autochthonous Peruvian natural plants as potential SARS-CoV-2 Mpro main protease inhibitors. PHARMACEUTICALS. 2023. DOI: 10.3390/ph16040585

  • Hermoso-Durán, S.; Domper-Arnal, M. J.; Roncales, P.; Vega, S.; Sánchez-Gracia, Ó.; Ojeda, J. L.; Lanas, Á.; Velázquez-Campoy, A.; Abian, O. Bowel preparation for colonoscopy changes serum composition as detected by thermal liquid biopsy and fluorescence spectroscopy. CANCERS. 2023. DOI: 10.3390/cancers15071952

  • Bastos, Margarida; Abian, Olga; Johnson, Christopher M.; Ferreira-Da-Silva, Frederico; Vega, Sonia; Jimenez-Alesanco, Ana; Ortega-Alarcon, David; Velazquez-Campoy, Adrian. Isothermal titration calorimetry. NATURE REVIEWS METHODS PRIMERS. 2023. DOI: 10.1038/s43586-023-00199-x

  • Ortega Alarcon, David; Claveria Gimeno, Rafael; Vega, Sonia; Jorge Torres, Olga C.; Esteller, Manel; Abian, Olga; Velazquez Campoy, Adrian. Unexpected thermodynamic signature for the interaction of hydroxymethylated DNA with MeCP2. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023. DOI: 10.1016/j.ijbiomac.2023.123373

  • Araujo-Abad, Salomé; Rizzuti, Bruno; Villamarin-Ortiz, Adrián; Pantoja-Uceda, David; Moreno-Gonzalez, Celia M.; Abian, Olga; Velazquez-Campoy, Adrián; Neira, José L.; de Juan Romero, Camino. New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4. PROTEIN SCIENCE. 2023. DOI: 10.1002/pro.4723

  • Losada-Garcia, Noelia; Vazquez-Calvo, Angela; Ortega-Alarcon, David; Abian, Olga; Velazquez-Campoy, Adrian; Domingo-Calap, Pilar; Alcami, Antonio; Palomo, Jose M. Nanostructured biohybrid material with wide-ranging antiviral action. NANO RESEARCH. 2023. DOI: 10.1007/s12274-023-5765-0

  • Rizzuti, Bruno; Abian, Olga; Velazquez-Campoy, Adrián; Neira, José L. Conformational Stability of the N-Terminal Region of MDM2. MOLECULES. 2023. DOI: 10.3390/molecules28227578

  • Neira, J. L.; Rizzuti, B.; Abián, O.; Araujo-Abad, S.; Velázquez-Campoy, A.; Juan Romero, C. de. Human enzyme PADI4 binds to the nuclear carrier Importin a3. CELLS. 2022. DOI: 10.3390/cells11142166

  • Neira, José L.; Araujo-Abad, Salomé; Cámara-Artigas, Ana; Rizzuti, Bruno; Abian, Olga; Giudici, Ana Marcela; Velazquez-Campoy, Adrián; Juan Romero, Camino de. Biochemical and biophysical characterization of PADI4 supports its involvement in cancer; 35081374. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2022. DOI: 10.1016/j.abb.2022.109125

  • Jimenez-Alesanco, Ana; Eckhard, Ulrich; Asencio del Rio, Marta; Vega, Sonia; Guevara, Tibisay; Velazquez-Campoy, Adrian; Gomis-Rüth, Francesc Xavier; Abian, Olga. Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis. PROTEIN SCIENCE. 2022. DOI: 10.1002/pro.4427

  • Neira, José L.; Rizzuti, Bruno; Araujo-Abad, Salome; Abian, Olga; Fárez-Vidal, María Esther; Velazquez-Campoy, Adrian; de Juan Romero, Camino. The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2022. DOI: 10.1016/j.bbapap.2022.140868

  • Roche, Alejandro; Morcuende-Ventura, Violeta; Tejedor, Rosa M.; Oriol, Luis; Abian, Olga; Piñol, Milagros. Evaluation of PEG-b-polycarbonates self-assemblies containing azobenzene or coumarin moieties as nanocarriers using paclitaxel as a model hydrophobic drug. JOURNAL OF MICROENCAPSULATION. 2022. DOI: 10.1080/02652048.2022.2061621

  • Domper Arnal, M.J.; García Mateo, S.; Hermoso-Durán, S.; Abad, D.; Carrera-Lasfuentes, P.; Velazquez-Campoy, A.; Abian Franco, O.; Lanas, A. False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2021. DOI: 10.1007/s00384-021-03947-1

  • Butrón D.; Zamora-Carreras H.; Devesa I.; Treviño M.A.; Abian O.; Velázquez-Campoy A.; Bonache M.Á.; Lagartera L.; Martín-Martínez M.; González-Rodríguez S.; Baamonde A.; Fernández-Carvajal A.; Ferrer-Montiel A.; Jiménez M.Á.; González-Muñiz R. DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target. BIOORGANIC CHEMISTRY. 2021. DOI: 10.1016/j.bioorg.2021.105231

  • Rubio-Martínez J.; Jiménez-Alesanco A.; Ceballos-Laita L.; Ortega-Alarcón D.; Vega S.; Calvo C.; Benítez C.; Abian O.; Velázquez-Campoy A.; Thomson T.M.; Granadino-Roldán J.M.; Gómez-Gutiérrez P.; Pérez J.J. Discovery of diverse natural products as inhibitors of SARS-CoV-2 Mpro protease through virtual screening. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2021. DOI: 10.1021/acs.jcim.1c00951

  • Neira J.L.; Rizzuti B.; Ortega-Alarcón D.; Giudici A.M.; Abián O.; Fárez-Vidal M.E.; Velázquez-Campoy A. The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73. BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2021. DOI: 10.1016/j.bbagen.2021.129914

  • Domper Arnal, M.J.; García Mateo, S.; Hermoso-Durán, S.; Abad, D.; Carrera-Lasfuentes, P.; Velazquez-Campoy, A.; Abian Franco, O.; Lanas, A. Correction to: False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use (International Journal of Colorectal Disease, (2021), 36, 9, (1861-1869), 10.1007/s00384-021-03947-1). INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2021. DOI: 10.1007/s00384-021-03965-z

  • Annesi, Ferdinanda; Hermoso-Durán, Sonia; Rizzuti, Bruno; Bruno, Rosalinda; Pirritano, Domenico; Petrone, Alfredo; del Giudice, Francesco; Ojeda, Jorge; Vega, Sonia; Sanchez-Gracia, Oscar; Velazquez-Campoy, Adrian; Abian, Olga; Guzzi, Rita. Thermal Liquid Biopsy (TLB) of Blood Plasma as a Potential Tool to Help in the Early Diagnosis of Multiple Sclerosis. JOURNAL OF PERSONALIZED MEDICINE. 2021. DOI: 10.3390/jpm11040295

  • Rizzuti, Bruno; Grande, Fedora; Conforti, Filomena; Jimenez-Alesanco, Ana; Ceballos-Laita, Laura; Ortega-Alarcon, David; Vega, Sonia; Reyburn, Hugh T.; Abian, Olga; Velazquez-Campoy, Adrian. Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs. BIOMEDICINES. 2021. DOI: 10.3390/biomedicines9040375

  • Paketurytè, Vaida; Petrauskas, Vytautas; Zubrienè, Asta; Abian, Olga; Bastos, Margarida; Chen, Wen-Yih; Moreno, Maria João; Krainer, Georg; Linkuvienè, Vaida; Sedivy, Arthur; Velazquez-Campoy, Adrian; Williams, Mark A.; Matulis, Daumantas. Uncertainty in protein-ligand binding constants: asymmetric confidence intervals versus standard errors. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2021. DOI: 10.1007/s00249-021-01518-4

  • Velazquez-Campoy, Adrian; Claro, Bárbara; Abian, Olga; Höring, Jonas; Bourlon, Louis; Claveria-Gimeno, Rafael; Ennifar, Eric; England, Patrick; Chaires, Jonathan Brad; Wu, Di; Piszczek, Grzegorz; Brautigam, Chad; Tso, Shih-Chia; Zhao, Huaying; Schuck, Peter; Keller, Sandro; Bastos, Margarida. A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2021. DOI: 10.1007/s00249-021-01523-7

  • López-Méndez, Blanca; Baron, Bruno; Brautigam, Chad A.; Jowitt, Thomas A.; Knauer, Stefan H.; Uebel, Stephan; Williams, Mark A.; Sedivy, Arthur; Abian, Olga; Abreu, Celeste; Adamczyk, Malgorzata; Bal, Wojciech; Berger, Sylvie; Buell, Alexander K.; Carolis, Carlo; Daviter, Tina; Fish, Alexander; Garcia-Alai, Maria; Guenther, Christian; Hamacek, Josef; Holková, Jitka; Houser, Josef; Johnson, Chris; Kelly, Sharon; Leech, Andrew; Mas, Caroline; Matulis, Daumantas; Mclaughlin, Stephen H.; Montserret, Roland; Nasreddine, Rouba; Nehmé, Reine; Nguyen, Quyen; Ortega-Alarcón, David; Perez, Kathryn; Pirc, Katja; Piszczek, Grzegorz; Podobnik, Marjetka; Rodrigo, Natalia; Rokov-Plavec, Jasmina; Schaefer, Susanne; Sharpe, Tim; Southall, June; Staunton, David; Tavares, Pedro; Vanek, Ondrej; Weyand, Michael; Wu, Di. Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2021. DOI: 10.1007/s00249-021-01532-6

  • Morcuende-Ventura, Violeta; Hermoso-Durán, Sonia; Abian-Franco, Natalia; Pazo-Cid, Roberto; Ojeda, Jorge L.; Vega, Sonia; Sanchez-Gracia, Oscar; Velazquez-Campoy, Adrian; Sierra, Teresa; Abian, Olga. Fluorescence Liquid Biopsy for Cancer Detection Is Improved by Using Cationic Dendronized Hyperbranched Polymer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. DOI: 10.3390/ijms22126501

  • Lopez-Tejedor, David; Claveria-Gimeno, Rafael; Velazquez-Campoy, Adrian; Abian, Olga; Palomo, Jose M. In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus. PHARMACEUTICALS. 2021. DOI: 10.3390/ph14080759

  • Ortega-Alarcon, David; Claveria-Gimeno, Rafael; Vega, Sonia; Jorge-Torres, Olga C.; Esteller, Manel; Abian, Olga; Velazquez-Campoy, Adrian. Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2. BIOMOLECULES. 2021. DOI: 10.3390/biom11081216

  • Rizzuti, Bruno; Ceballos-Laita, Laura; Ortega-Alarcon, David; Jimenez-Alesanco, Ana; Vega, Sonia; Grande, Fedora; Conforti, Filomena; Abian, Olga; Velazquez-Campoy, Adrian. Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds. PHARMACEUTICALS. 2021. DOI: 10.3390/ph14090892

  • Rizzuti, Bruno; Lan, Wenjun; Santofimia-Castaño, Patricia; Zhou, Zhengwei; Velázquez-Campoy, Adrián; Abián, Olga; Peng, Ling; Neira, José L.; Xia, Yi; Iovanna, Juan L. Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function. BIOMOLECULES. 2021. DOI: 10.3390/biom11101453

  • Sancineto, Luca; Ostacolo, Carmine; Ortega-Alarcon, David; Jimenez-Alesanco, Ana; Ceballos-Laita, Laura; Vega, Sonia; Abian, Olga; Velazquez-Campoy, Adrian; Moretti, Silvia; Dabrowska, Agnieszka; Botwina, Pawel; Synowiec, Aleksandra; Kula-Pacurar, Anna; Pyrc, Krzysztof; Iraci, Nunzio; Santi, Claudio. l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells. MOLECULES. 2021. DOI: 10.3390/molecules26196062

  • López-Méndez, Blanca; Baron, Bruno; Brautigam, Chad A.; Jowitt, Thomas A.; Knauer, Stefan H.; Uebel, Stephan; Williams, Mark A.; Sedivy, Arthur; Abian, Olga; Abreu, Celeste; Adamczyk, Malgorzata; Bal, Wojciech; Berger, Sylvie; Buell, Alexander K.; Carolis, Carlo; Daviter, Tina; Fish, Alexander; Garcia-Alai, Maria; Guenther, Christian; Hamacek, Josef; Holková, Jitka; Houser, Josef; Johnson, Chris; Kelly, Sharon; Leech, Andrew; Mas, Caroline; Matulis, Daumantas; Mclaughlin, Stephen H.; Montserret, Roland; Nasreddine, Rouba; Nehmé, Reine; Nguyen, Quyen; Ortega-Alarcón, David; Perez, Kathryn; Pirc, Katja; Piszczek, Grzegorz; Podobnik, Marjetka; Rodrigo, Natalia; Rokov-Plavec, Jasmina; Schaefer, Susanne; Sharpe, Tim; Southall, June; Staunton, David; Tavares, Pedro; Vanek, Ondrej; Weyand, Michael; Wu, Di. Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2021. DOI: 10.1007/s00249-021-01573-x

  • Hermoso-Durán, S.; García-Rayado, G.; Ceballos-Laita, L.; Sostres, C.; Vega, S.; Millastre, J.; Sánchez-Gracia, O.; Ojeda, J.L.; Lanas, Á.; Velázquez-Campoy, A.; Abian, O. Thermal liquid biopsy (TLB) focused on benign and premalignant pancreatic cyst diagnosis. JOURNAL OF PERSONALIZED MEDICINE. 2021. DOI: 10.3390/jpm11010025

  • Ortega-Alarcon, D.; Claveria-Gimeno, R.; Vega, S.; Jorge-Torres, O.C.; Esteller, M.; Abian, O.; Velazquez-Campoy, A. Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2021. DOI: 10.1016/j.ijbiomac.2021.01.206

  • Losada-Garcia, N.; Jimenez-Alesanco, A.; Velazquez-Campoy, A.; Abian, O.; Palomo, J.M. Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy. ACS APPLIED MATERIALS & INTERFACES. 2021. DOI: 10.1021/acsami.0c20501

  • Mangiavacchi F.; Botwina P.; Menichetti E.; Bagnoli L.; Rosati O.; Marini F.; Fonseca S.F.; Abenante L.; Alves D.; Dabrowska A.; Kula-Pacurar A.; Ortega-Alarcon D.; Jimenez-Alesanco A.; Ceballos-Laita L.; Vega S.; Rizzuti B.; Abian O.; Lenardão E.J.; Velazquez-Campoy A.; Pyrc K.; Sancineto L.; Santi C. Seleno-functionalization of quercetin improves the non-covalent inhibition of mpro and its antiviral activity in cells against sars-cov-2. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021. DOI: 10.3390/ijms22137048

  • Bensabeh, N.; Jiménez-Alesanco, A.; Liblikas, I.; Ronda, J.C.; Cádiz, V.; Galià, M.; Vares, L.; Abián, O.; Lligadas, G. Biosourced All-Acrylic ABA Block Copolymers with Lactic Acid-Based Soft Phase. MOLECULES. 2020. DOI: 10.3390/molecules25235740

  • Anselmo, M.S.; Lancelot, A.; Egido, J.E.; Clavería-Gimeno, R.; Casanova, Á.; Serrano, J.L.; Hernández-Ainsa, S.; Abian, O.; Sierra, T. Janus dendrimers to assess the anti-hcv activity of molecules in cell-assays. PHARMACEUTICS. 2020. DOI: 10.3390/pharmaceutics12111062

  • Ortega-Alarcon, D.; Claveria-Gimeno, R.; Vega, S.; Jorge-Torres, O.C.; Esteller, M.; Abian, O.; Velazquez-Campoy, A. Molecular context-dependent effects induced by rett syndrome-associated mutations in mecp2. BIOMOLECULES. 2020. DOI: 10.3390/biom10111533

  • Neira, J.L.; Rizzuti, B.; Jiménez-Alesanco, A.; Palomino-Schätzlein, M.; Abián, O.; Velázquez-Campoy, A.; Iovanna, J.L. A phosphorylation-induced switch in the nuclear localization sequence of the intrinsically disordered nupr1 hampers binding to importin. BIOMOLECULES. 2020. DOI: 10.3390/biom10091313

  • Mateo, Cesar; Abian, Olga; Fernandez-Lorente, Gloria; Pessela, Benevides C. C.; Grazu, Valeria; Guisan, Jose M.; Fernandez-Lafuente, Roberto. Multi-Point Covalent Immobilization of Enzymes on Supports Activated with Epoxy Groups: Stabilization of Industrial Enzymes. METHODS IN MOLECULAR BIOLOGY. 2020. DOI: 10.1007/978-1-0716-0215-7_6

  • Neira, J.L.; Rizzuti, B.; Jiménez-Alesanco, A.; Abián, O.; Velázquez-Campoy, A.; Iovanna, J.L. The paralogue of the intrinsically disordered nuclear protein 1 has a nuclear localization sequence that binds to human importin a3. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. DOI: 10.3390/ijms21197428

  • Jaramillo, J.; Rodriguez-Oliva, I.; Abian, O.; Palomo, J.M. Specific chemical incorporation of L-DOPA and functionalized L-DOPA-hyaluronic acid in Candida antarctica lipase: creating potential mussel-inspired bioadhesives. SN APPLIED SCIENCES. 2020. DOI: 10.1007/s42452-020-03545-w

  • Santofimia-Castaño, P.; Rizzuti, B.; Xia, Y.; Abian, O.; Peng, L.; Velázquez-Campoy, A.; Neira, J.L.; Iovanna, J. Targeting intrinsically disordered proteins involved in cancer. CELLULAR AND MOLECULAR LIFE SCIENCES. 2020. DOI: 10.1007/s00018-019-03347-3

  • Abian, O.; Ortega-Alarcon, D.; Jimenez-Alesanco, A.; Ceballos-Laita, L.; Vega, S.; Reyburn, H.T.; Rizzuti, B.; Velazquez-Campoy, A. Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2020. DOI: 10.1016/j.ijbiomac.2020.07.235

  • Moreno, A.; Jiménez-Alesanco, A.; Ronda, J.C.; Cádiz, V.; Galià, M.; Percec, V.; Abian, O.; Lligadas, G. Dual Biochemically Breakable Drug Carriers from Programmed Telechelic Homopolymers. BIOMACROMOLECULES. 2020. DOI: 10.1021/acs.biomac.0c01113

  • Neira, José L.;Correa, Juan;Rizzuti, Bruno;Santofimia-Castano, Patricia;Abian, Olga;Velazquez-Campoy, Adrián;Fernandez-Megia, Eduardo;Iovanna, Juan L. Dendrimers as Competitors of Protein–Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. BIOMACROMOLECULES. 2019. DOI: 10.1021/acs.biomac.9b00378

  • Santofimia-Castaño, Patricia; Xia, Yi; Lan, Wenjun; Zhou, Zhengwei; Huang, Can; Peng, Ling; Soubeyran, Philippe; Velázquez-Campoy, Adrián; Abián, Olga; Rizzuti, Bruno; Neira, José L.; Iovanna, Juan. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. JOURNAL OF CLINICAL INVESTIGATION. 2019. DOI: 10.1172/jci127223

  • Claveria-Gimeno, R.; Vega, S.; Abian, O.; Velazquez-Campoy, A. Tinkering with Binding Polynomials in Isothermal Titration Calorimetry. METHODS IN MOLECULAR BIOLOGY. 2019. DOI: 10.1007/978-1-4939-9179-2_14

  • Perez-Rizquez, Carlos; Abian, Olga; Palomo, José M. Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C-H activation in aqueous media. CHEMICAL COMMUNICATIONS. 2019. DOI: 10.1039/c9cc06971b

  • Rodrigo, Alberto; Ojeda, Jorge L.; Vega, Sonia; Sanchez-Gracia, Óscar; Lanas, Ángel; Isla, Dolores; Velazquez-Campoy, Adrián; Abian, Olga. Thermal liquid biopsy (Tlb): A predictive score derived from serum thermograms as a clinical tool for screening lung cancer patients. CANCERS. 2019. DOI: 10.3390/cancers11071012

  • Martínez de Paz, A.; Khajavi, L.; Martin, H.; Claveria-Gimeno, R.; Tom Dieck, S.; Cheema, M.S.; Sanchez-Mut, J.V.; Moksa, M.M.; Carles, A.; Brodie, N.I.; Sheikh, T.I.; Freeman, M.E.; Petrotchenko, E.V.; Borchers, C.H.; Schuman, E.M.; Zytnicki, M.; Velazquez-Campoy, A.; Abian, O.; Hirst, M.; Esteller, M.; Vincent, J.B.; Malnou, C.E.; Ausió, J. MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2. EPIGENETICS & CHROMATIN. 2019. DOI: 10.1186/s13072-019-0298-1

  • Felix, Jan; Weinhäupl K.; Chipot C.; Dehez F.; Hessel A.; Gauto D.F.; Morlot C.; Abian, Olga; Gutsche I.; Velazquez-Campoy A.; Schanda P.; Fraga H. Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. SCIENCE. 2019. DOI: 10.1126/sciadv.aaw3818

  • Gálvez, José A.; Clavería-Gimeno, Rafael; Galano-Frutos, Juan J.; Sancho, Javier; Velázquez-Campoy, Adrian; Abian, Olga; Díaz-De-Villegas, María D. Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019. DOI: 10.1016/j.ejmech.2019.03.019

  • Vega, S.; Abian, O.; Velazquez-Campoy, A. Handling complexity in biological interactions: Allostery and cooperativity in proteins. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY. 2019. DOI: 10.1007/s10973-019-08610-0

  • Santofimia-Castaño, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga; Peng, Ling; Velázquez-Campoy, Adrián; Iovanna, Juan L.; Neira, José L. Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm. MOLECULAR & CELLULAR ONCOLOGY. 2019. DOI: 10.1080/23723556.2019.1612678

  • Santofimia-Castaño, P.; Xia, Y.; Peng, L.; Velázquez-Campoy, A.; Abián, O.; Lan, W.; Lomberk, G.; Urrutia, R.; Rizzuti, B.; Soubeyran, P.; Neira, J.L.; Iovanna, J. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. CELLS. 2019. DOI: 10.3390/cells8111453

  • Santofimia-Castaño, Patricia; Rizzuti, Bruno; Abián, Olga; Velázquez-Campoy, Adrián; Iovanna, Juan L.; Neira, J. L. Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1). BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2018. DOI: 10.1016/j.bbagen.2018.03.009

  • Velazquez-Campoy, A.; Vega, S.; Sanchez-Gracia, O.; Lanas, A.; Rodrigo, A.; Kaliappan, A.; Hall, M.B.; Nguyen, T.Q.; Brock, G.N.; Chesney, J.A.; Garbett, N.C.; Abian, O. Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study. BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2018. DOI: 10.1016/j.bbagen.2018.04.020

  • Neira, J.L.; Hornos, F.; Cozza, C.; Cámara-Artigas, A.; Abián, O.; Velázquez-Campoy, A. The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2018. DOI: 10.1016/j.abb.2017.12.017

  • Lancelot, Alexandre; González-Pastor, Rebeca; Clavería-Gimeno, Rafael; Romero, Pilar; Abian, Olga; Martín-Duque, Pilar; Serrano, José L.; Sierra, Teresa. Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications. JOURNAL OF MATERIALS CHEMISTRY B. 2018. DOI: 10.1039/C8TB00639C

  • Gracia, R.; Yus, C.; Abian, O.; Mendoza, G.; Irusta, S.; Sebastian, V.; Andreu, V.; Arruebo, M. Enzyme structure and function protection from gastrointestinal degradation using enteric coatings. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2018. DOI: 10.1016/j.ijbiomac.2018.07.143

  • Neira, José L.; Bintz, Jennifer; Arruebo, Maria; Rizzuti, Bruno; Bonacci, Thomas; Vega Sánchez, Sonia; Lanas, Angel; Velázquez-Campoy, Adrian; Iovanna, Juan L.; Abian, Olga. Blocking Nupr1 Protein, A Successful Approach for Pancreatic Adenocarcinoma Treatment. GASTROENTEROLOGY. 2017. DOI: 10.1016/S0016-5085(17)30503-6

  • Claveria-Gimeno, R.; Lanuza, P.M.; Morales-Chueca, I.; Jorge-Torres, O.C.; Vega, S.; Abian, O.; Esteller, M.; Velazquez-Campoy, A. The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/srep41635

  • Claveria-Gimeno, R.; Vega, S.; Abian, O.; Velazquez-Campoy, A. A look at ligand binding thermodynamics in drug discovery. EXPERT OPINION ON DRUG DISCOVERY. 2017. DOI: 10.1080/17460441.2017.1297418

  • Lancelot, A.; Clavería-Gimeno, R.; Velázquez-Campoy, A.; Abian, O.; Serrano, J. L.; Sierra, T. Nanostructures based on ammonium-terminated amphiphilic Janus dendrimers as camptothecin carriers with antiviral activity. EUROPEAN POLYMER JOURNAL. 2017. DOI: 10.1016/j.eurpolymj.2017.03.012

  • Filice, M.; Molina, M.; Benaiges, M.D.; Abian, O.; Valero, F.; Palomo, J.M. Solid-surface activated recombinant: Rhizopous oryzae lipase expressed in Pichia pastoris and chemically modified variants as efficient catalysts in the synthesis of hydroxy monodeprotected glycals. CATALYSIS SCIENCE AND TECHNOLOGY. 2017. DOI: 10.1039/c7cy00255f

  • Neira, J.L.; Bintz, J.; Arruebo, M.; Rizzuti, B.; Bonacci, T.; Vega, S.; Lanas, A.; Velázquez-Campoy, A.; Iovanna, J.L.; Abián, O. Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/srep39732

  • Vega, S.; Abian, O.; Velazquez-Campoy, A. On the link between conformational changes, ligand binding and heat capacity. BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2016. DOI: 10.1016/j.bbagen.2015.10.010

  • Oriol Langa, Luis Teodoro; Concellón, A.; Clavería-Gimeno, R.; Velázquez-Campoy, A.; Abian, O.; Piñol, M. Polymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs. RSC ADVANCES. 2016. DOI: 10.1039/c6ra01714b

  • López, V.; Pérez, S.; Vinuesa, A.; Zorzetto, C.; Abian, O. Stevia rebaudiana ethanolic extract exerts better antioxidant properties and antiproliferative effects in tumour cells than its diterpene glycoside stevioside. FOOD & FUNCTION. 2016. DOI: 10.1039/c5fo01586c

  • Velázquez-Campoy,A.;Sancho,J.;Abian,O;Vega,S.;. Biophysical screening for identifying pharmacological chaperones and inhibitors against conformational and infectious diseases. CURRENT DRUG TARGETS. 2016. DOI: 10.2174/1389450117666160201110449

  • Claveria-Gimeno, R.; Abian, O.; Velazquez-Campoy, A.; Ausio, J. MeCP2… Nature’s wonder protein or Medicine’s most feared one?. CURRENT GENETIC MEDICINE REPORTS. 2016. DOI: 10.1007/s40142-016-0107-0

  • Botello-Morte,L;Pellicer,S.;Contreras,L. M.;Neira,J. L.;Abian,O.;Velazquez-Campoy,A.;Peleato,M. L.;Fillat,M. F.;Bes,M. T.;. Cysteine mutational studies provide insight into a thiol-based redox switch mechanism of metal and DNA binding in FurA from Anabaena sp. PCC 7120. ANTIOXIDANTS & REDOX SIGNALING. 2016. DOI: 10.1089/ars.2014.6175

  • Vega, S.; Abian, O.; Velazquez-Campoy, A. A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry. METHODS. 2015. DOI: 10.1016/j.ymeth.2014.09.010

  • Vega, S.; Garcia-Gonzalez, M.; Lanas, A.; Velazquez-Campoy, A.; Abian, O. Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2015. DOI: 10.1038/srep07988

  • Claveria-Gimeno, R.; Vega, S.; Grazu, V.; de la Fuente, J.M.; Lanas, A.; Velazquez-Campoy, A.; Abian, O. Rescuing compound bioactivity in a secondary cell-based screening by using gamma-cyclodextrin as a molecular carrier. INTERNATIONAL JOURNAL OF NANOMEDICINE. 2015. DOI: 10.2147/IJN.S79480

  • Jiménez-Pardo, Isabel; González-Pastor, Rebeca; Lancelot, Alexandre; Claveria-Gimeno, Rafael; Velázquez-Campoy, Adrián; Abian, Olga; Ros, M. Blanca; Sierra, Teresa. Shell cross-linked polymeric micelles as Camptothecin nanocarriers for anti-HCV therapy. MACROMOLECULAR BIOSCIENCE. 2015. DOI: 10.1002/mabi.201500094

  • Filice,M.; Romero,O.; Abian,O.; de las Rivas, B.; Palomo,J. M. Low ionic liquid concentration in water: A green and simple approach to improve activity and selectivity of lipases. RSC ADVANCES. 2014. DOI: 10.1039/c4ra07625g

  • Cortes-Ciriano,I.;Koutsoukas,A.;Abian,O.;Glen,R. C.;Velazquez-Campoy,A.;Bender,A. Experimental validation of in silico target predictions on synergistic protein targets. MEDCHEMCOMM. 2013. DOI: 10.1039/c2md20286g

  • Abian, O.; Vega, S.; Sancho, J.; Velazquez-Campoy, A. Allosteric Inhibitors of the NS3 Protease from the Hepatitis C Virus. PLOS ONE. 2013. DOI: 10.1371/journal.pone.0069773

  • Vega,S.; Neira,J. L.; Marcuello,C.; Lostao,A.; Abian,O.; Velazquez-Campoy,A. NS3 protease from hepatitis C virus: Biophysical studies on an intrinsically disordered protein domain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013. DOI: 10.3390/ijms140713282

  • Martinez-Julvez,M.;Abian,O.;Vega,S.;Medina,M.;Velazquez-Campoy,A. Studying the allosteric energy cycle by isothermal titration calorimetry. METHODS IN MOLECULAR BIOLOGY. 2012. DOI: 10.1007/978-1-61779-334-9_4

  • Romero,O.;Filice,M.;De,Las Rivas;Carrasco-Lopez,C.;Klett,J.;Morreale,A.;Hermoso,J. A.;Guisan,J. M.;Abian,O.;Palomo,J. M. Semisynthetic peptide-lipase conjugates for improved biotransformations. CHEMICAL COMMUNICATIONS. 2012. DOI: 10.1039/c2cc34816k

  • López-Gallego, F.;Abian, O.;Guisán, J. M. Altering the interfacial activation mechanism of a lipase by solid-phase selective chemical modification. BIOCHEMISTRY. 2012. DOI: 10.1021/bi300799v

  • Abian,O.; Alfonso,P.; Velazquez-Campoy,A.; Giraldo,P.; Pocovi,M.; Sancho,J. Therapeutic strategies for Gaucher disease: Miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. MOLECULAR PHARMACEUTICS. 2011. DOI: 10.1021/mp200313e

  • Gutarra,M. L. E.;Romero,O.;Abian,O.;Torres,F. A. G.;Freire,D. M. G.;Castro,A. M.;Guisan,J. M.;Palomo,J. M. Enzyme surface glycosylation in the solid phase: Improved activity and selectivity of Candida antarctica lipase B. CHEMCATCHEM. 2011. DOI: 10.1002/cctc.201100211

  • Pérez-Llarena, F. J.; Kerff, F.; Abián, O.; Mallo, S.; Fernández, M. C.; Galleni, M.; Sancho, J.; Bou, G. Distant and new mutations in CTX-M-1 ß-lactamase affect cefotaxime hydrolysis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2011. DOI: 10.1128/AAC.00298-11

  • Ayuso-Tejedor,S.;Abián,O.;Velázquez-Campoy,A.;Sancho,J. Mechanism of FMN binding to the apoflavodoxin from Helicobacter pylori. BIOCHEMISTRY. 2011. DOI: 10.1021/bi201025y

  • Ayuso-Tejedor, S.; Abián, O.; Sancho, J. Underexposed polar residues and protein stabilization. PROTEIN ENGINEERING DESIGN & SELECTION. 2011. DOI: 10.1093/protein/gzq072

  • Grazú, V.;López-Gallego, F.;Montes, T.;Abian, O.;González, R.;Hermoso, J. A.;García, J. L.;Mateo, C. ;Guisán, J. M. Promotion of multipoint covalent immobilization through different regions of genetically modified penicillin G acylase from E. coli. PROCESS BIOCHEMISTRY. 2010

  • Domenech, R.;Abian, O.;Bocanegra, R.;Correa, J.;Sousa-Herves, A.;Riguera, R.;Mateu, M. G.;Fernandez-Megia, E.;Velazquez-Campoy, A. ;Neira, J. L. Dendrimers as potential inhibitors of the dimerization of the capsid protein of HIV-1. BIOMACROMOLECULES. 2010

  • Ayuso-Tejedor, S.;Angarica, V. E.;Bueno, M.;Campos, L. A.;Abian, O.;Bernado, P.;Sancho, J. ;Jimenez, M. A. Design and structure of an equilibrium protein folding intermediate: A hint into dynamical regions of proteins. JOURNAL OF MOLECULAR BIOLOGY. 2010

  • Abian, O.;Vega, S.;Neira, J. L. ;Velazquez-Campoy, A. Conformational stability of hepatitis C virus NS3 protease. BIOPHYSICAL JOURNAL. 2010. DOI: 10.1016/j.bpj.2010.10.037

  • Abián, M.;Silva, S. L.;Millera, A.;Bilbao, R. ;Alzueta, M. U. Effect of operating conditions on NO reduction by acetylene-ethanol mixtures. FUEL PROCESSING TECHNOLOGY. 2010

  • Abian, O.;Neira, J. Luis;Velazquez-Campoy, A. Thermodynamics of Zinc Binding to Hepatitis C Virus NS3 Protease: A Folding by Binding Event. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2009

  • Hurtado-Gomez,E.;Abian,O.;Muñoz,F. J.;Hernaiz,M. J.;Velazquez-Campoy,A.;Neira,J. L. Defining the epitope region of a peptide from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system able to bind to the enzyme I. BIOPHYSICAL JOURNAL. 2008. DOI: 10.1529/biophysj.107.126664

  • Grazú,V.;Abian,O.;Mateo,C.;Batista-Viera,F.;Fernández-Lafuente,R.;Guisán,J. M. Stabilization of enzymes by multipoint immobilization of thiolated proteins on new epoxy-thiol supports. BIOTECHNOLOGY AND BIOENGINEERING. 2005. DOI: 10.1002/bit.20452

  • Mateo,C.;Abian,O.;Bernedo,M.;Cuenca,E.;Fuentes,M.;Fernandez-Lorente,G.;Palomo,J. M.;Grazu,V.;Pessela,B. C. C.;Giacomini,C.;Irazoqui,G.;Villarino,A.;Ovsejevi,K.;Batista-Viera,F.;Fernandez-Lafuente,R.;Guisán,J. M. Some special features of glyoxyl supports to immobilize proteins. ENZYME AND MICROBIAL TECHNOLOGY. 2005. DOI: 10.1016/j.enzmictec.2005.03.020

  • Mateo,C.;Abian,O.;Grazú,V.;Fernández-Lorente,G.;Palomo,J. M.;Fuentes,M.;Segura,R. L.;Montes,T.;López-Gallego,F.;Wilson,L.;Torres,R.;Guisán,J. M.;Fernández-Lafuente,R. Recent advances in the industrial enzymatic synthesis of semi-synthetic ß-lactam antibiotics. MEDICINAL CHEMISTRY REVIEWS. 2005

  • Wilson,L.;Illanes,A.;Pessela,B. C. C.;Abian,O.;Fernández-Lafuente,R.;Guisán,J. M. Encapsulation of crosslinked penicillin G acylase aggregates in lentikats: Evaluation of a novel biocatalyst in organic media. BIOTECHNOLOGY AND BIOENGINEERING. 2004. DOI: 10.1002/bit.20107

  • Fuentes, M.; Segura, R. L.; Abian, O.; Betancor, L.; Hidalgo, A.; Mateo, C.; Fernandez-Lafuente, R.; Guisan, J. M. Determination of protein-protein interactions through aldehyde-dextran intermolecular cross-linking. PROTEOMICS. 2004. DOI: 10.1002/pmic.200300766

  • Fuentes, M.; Pessela, B. C. C.; Maquiese, J. V.; Ortiz, C.; Segura, R. L.; Palomo, J. M.; Abian, O.; Torres, R.; Mateo, C.; Fernández-Lafuente, R.; Guisán, J. M. Reversible and strong immobilization of proteins by ionic exchange on supports coated with sulfate-dextran. BIOTECHNOLOGY PROGRESS. 2004. DOI: 10.1021/bp0499449

  • Fuentes, M.; Maquiese, J. V.; Pessela, B. C. C.; Abian, O.; Fernández-Lafuente, R.; Mateo, C.; Guisán, J. M. New Cationic Exchanger Support for Reversible Immobilization of Proteins. BIOTECHNOLOGY PROGRESS. 2004. DOI: 10.1021/bp0342102

  • Abian, O.; Mateo, C.; Palomo, J. M.; Fernández-Lorente, G.; Guisán, J. M.; Fernández-Lafuente, R. Enantioselective synthesis of phenylacetamides in the presence of high organic cosolvent concentrations catalyzed by stabilized penicillin G acylase. Effect of the acyl donor. BIOTECHNOLOGY PROGRESS. 2004. DOI: 10.1021/bp034354g

  • Abian, O.; Mateo, C.; Fernández-Lorente, G.; Guisán, J. M.; Fernández-Lafuente, R. Thermodynamically Controlled Synthesis of Amide Bonds Catalyzed by Highly Organic Solvent-Resistant Penicillin Acylase Derivatives. BIOTECHNOLOGY PROGRESS. 2004. DOI: 10.1021/bp034266w

  • Wilson,L.;Illanes,A.;Abián,O.;Pessela,B. C. C.;Fernández-Lafuente,R.;Guisán,J. M. Co-aggregation of penicillin G acylase and polyionic polymers: An easy methodology to prepare enzyme biocatalysts stable in organic media. BIOMACROMOLECULES. 2004. DOI: 10.1021/bm0343895

  • Abian,O.;Grazú,V.;Hermoso,J.;González,R.;García,J. L.;Fernández-Lafuente,R.;Guisán,J. M. Stabilization of Penicillin G Acylase from Escherichia coli: Site-Directed Mutagenesis of the Protein Surface to Increase Multipoint Covalent Attachment. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004. DOI: 10.1128/AEM.70.2.1249-1251.2004

  • Abian,O.;Mateo,C.;Fernández-Lorente,G.;Guisán,J. M.;Fernández-Lafuente,R. Improving the Industrial Production of 6-APA: Enzymatic Hydrolysis of Penicillin G in the Presence of Organic Solvents. BIOTECHNOLOGY PROGRESS. 2003. DOI: 10.1021/bp0340786

  • Mateo,C.;Torres,R.;Fernández-Lorente,G.;Ortiz,C.;Fuentes,M.;Hidalgo,A.;López-Gallego,F.;Abian,O.;Palomo,J. M.;Betancor,L.;Pessela,B. C. C.;Guisan,J. M.;Fernández-Lafuente,R. Epoxy-amino groups: A new tool for improved immobilization of proteins by the epoxy method. BIOMACROMOLECULES. 2003. DOI: 10.1021/bm0257661

  • Grazú, V.; Abian, O.; Mateo, C.; Batista-Viera, F.; Fernández-Lafuente, R.; Guisán, J. M. Novel bifunctional epoxy/thiol-reactive support to immobilize thiol containing proteins by the epoxy chemistry. BIOMACROMOLECULES. 2003. DOI: 10.1021/bm034262f

  • Abian,O.;Wilson,L.;Mateo,C.;Fernández-Lorente,G.;Palomo,J. M.;Fernández-Lafuente,R.;Guisán,J. M.;Re,D.;Tam,A.;Daminatti,M. Preparation of artificial hyper-hydrophilic micro-environments (polymeric salts) surrounding enzyme molecules: New enzyme derivatives to be used in any reaction medium. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. 2002. DOI: 10.1016/S1381-1177(02)00180-7

  • Mateo,C.;Abian,O.;Fernández-Lorente,G.;Pedroche,J.;Fernández-Lafuente,R.;Guisan,J. M.;Tam,A.;Daminati,M. Epoxy Sepabeads: A novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment. BIOTECHNOLOGY PROGRESS. 2002. DOI: 10.1021/bp010171n

  • Abian,O.;Mateo,C.;Fernández-Lorente,G.;Palomo,J. M.;Fernández-Lafuente,R.;Guisán,J. M. Erratum: Stabilization of immobilized enzymes against water-soluble organic cosolvents and generation of hyper-hydropholic micro-environments surrounding enzyme molecules (Biocatalysis and Biotransformation (2001) 19 5-6 (489-503)). BIOCATALYSIS AND BIOTRANSFORMATION. 2002

  • Abian,O.;Mateo,C.;Fernández-Lorente,G.;Palomo,J. M.;Fernández-Lafuente,R.;Guisán,J. M. Stabilization of immobilized enzymes against water-soluble organic cosolvents and generation of hyperhydrophilic micro-environments surrounding enzyme molecules. BIOCATALYSIS AND BIOTRANSFORMATION. 2001

  • Abian, O.; Mateo, C.; Fernández-Lorente, G.; Palomo, J. M.; Fernández-Lafuente, R.; Guisán, J. M. Stabilization of Immobilized Enzymes Against Water-Soluble Organic Cosolvents and Generation of Hyper-Hydrophilic Micro-Environments Surrounding Enzyme Molecules. BIOCATALYSIS AND BIOTRANSFORMATION. 2001. DOI: 10.3109/10242420108992032

  • Mateo,  cesar ; Fernández-Lorente,  gloria; Abian,  olga; Fernández-Lafuente, Roberto; Guisán, Jose M. Multifunctional Epoxy Supports:¿ A New Tool To Improve the Covalent Immobilization of Proteins. The Promotion of Physical Adsorptions of Proteins on the Supports before Their Covalent Linkage. BIOMACROMOLECULES. 2000. DOI: 10.1021/bm000071q

  • Mateo,C.;Abian,O.;Fernandez-Lafuente,R.;Guisan,J. M. Reversible enzyme immobilization via a very strong and nondistorting ionic adsorption on support-polyethylenimine composites. BIOTECHNOLOGY AND BIOENGINEERING. 2000. DOI: 10.1002/(SICI)1097-0290(20000405)68:1<98::AID-BIT12>3.0.CO;2-T

  • Mateo,C.;Abian,O.;Fernandez-Lafuente,R.;Guisan,J. M. Increase in conformational stability of enzymes immobilized on epoxy-activated supports by favoring additional multipoint covalent attachment. ENZYME AND MICROBIAL TECHNOLOGY. 2000. DOI: 10.1016/S0141-0229(99)00188-X

  • Mateo,C.;Fernández-Lorente,G.;Abian,O.;Fernández-Lafuente,R.;Guisán,J. M. Multifunctional epoxy supports: A new tool to improve the covalent immobilization of proteins. The promotion of physical adsorptions of proteins on the supports before their covalent linkage. BIOMACROMOLECULES. 2000

Comunicaciones

  • Rodrigo, A.; Vega, S.; Ojeda Cabrera, J.; Sanchez-Gracia, O.; Callejo, A.; Fernandez, A.; Iranzo, P.; Cruellas Lapena, M.; Quilez Bielsa, E.; Velazquez-Campoy, A.; Abian, O.; Isla, D. Thermal liquid biopsy as a valuable tool in lung cancer screening programs. ANNALS OF ONCOLOGY. 2019. DOI: 10.1093/annonc/mdz257.019

  • Abian, N.; Vega, S.; Hermoso, S.; Tauste, C.; Gaston, B.; Muruzabal, J.C.; Sanchez, O.; Abian, O.; Velazquez-Campoy, A. Thermal liquid biopsy (TLB) as a new diagnostic tool for patients with ovarian cancer: a pilot study. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2019. DOI: 10.1136/ijgc-2019-ESGO.1040

Capítulos

  • Studying the allosteric energy cycle by isothermal titration calorimetry. Martínez-Júlvez, Marta; Abian, Olga; Vega, Sonia; Medina, Milagros; Velázquez-Campoy, Adrián. METHODS IN MOLECULAR BIOLOGY ALLOSTERY: METHODS AND PROTOCOLS. . 2012



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