Perfil (CV) del personal docente investigador

Medina Trullenque, María Milagros

Departamento: Departamento de Bioquímica y Biología Molecular y Celular

Área: Bioquímica y Biología Molecular

Centro: Facultad de Ciencias

Research Institute: INSTITUTO DE BIOCOMPUTACIÓN Y FÍSICA DE SISTEMAS COMPLEJOS (BIFI)

Grupo: E35_23R: Grupo de referencia biología estructural

Códigos UNESCO

Bioquímica
Biofísica

Tramos de investigación

CNEAI research evaluation. 01/01/19
CNEAI research evaluation. 01/01/13
CNEAI research evaluation. 01/01/07
CNEAI research evaluation. 01/01/01. (2)

Categoría profesional: Cated. Universidad

Correo electrónico: mmedina@unizar.es

ORCID: 0000-0001-8743-0182

Líneas de investigación

Biomedicina
Mecanismos moleculares de enfermedad
Bioenergética
Biología estructural
Bioinformática
Organismos modificados genéticamente
Tecnología bioquímica

Titulaciones universitarias

Licenciado en Ciencias Químicas Especialidad Química Orgánica. Universidad de Zaragoza. 1987

Doctorados

Doctor en Ciencias (Bioquimica). Universidad de Zaragoza. 1992



Obtuve el doctorado en Bioquímica en 1992 (UNIZAR). Tras un periodo postdoctoral de tres meses en la University of Arizona (EEUU, 1992, medida de cinéticas rápidas) y otro de dos años en King´s College London (UK, 1993-1994, flavoproteinas, metaloproteínas y técnicas de resonancia paramagnética electrónica, Contrato EU), regresé a UNIZAR en 1995 con un contrato de Reincorporación-MEC. En 1997 obtuve el Premio Boehringer-Manheinn de SEBBM. En 1998 promocioné a Profesor Titular Interino en el Departamento de Bioquímica y Biología Molecular y Celular (UNIZAR), en 1999 obtuve mediante concurso-oposición una plaza de Profesor Titular, fui Profesora Secretaria (2004-2006) del citado Departamento. En 2011 promocioné a Catedrática de Bioquímica y Biología Molecular y en el periodo 2015-2019 fui Coordinadora del Grado en Biotecnología en UNIZAR. Desde 2001 soy Investigadora Senior del Instituto de Universitario de Biocomputación y Física de Sistemas Complejos, del que fui Subdirectora en 2009-2011, y vuelvo a serlo desde Febrero de 2019. Soy IP del grupo Flavoenzimas desde 2001, y del Grupo de Referencia del Gobierno de Aragón “Biología Estructural” desde 2017. Investigo la relación estructura-función en procesos metabólicos dependientes de reacciones de óxido-reducción mediadas por proteínas redox, enzimas y coenzimas. En particular mi interés se centra en comprender la versatilidad de flavoproteínas y flavoenzimas como eficientes y sofisticados instrumentos moleculares que utilizan reconocimiento molecular para regular procesos celulares, así como entender los efectos a nivel molecular de mutaciones que cursan con pérdida de función, y utilizar este conocimiento para incrementar la utilización de estas proteínas en aplicaciones biotecnológicas y terapéuticas. Para ello, combino un gran número de herramientas bioquímicas y biofísicas con la utilización de métodos computacionales. Soy activa en la comunidad internacional que trabaja en flavoproteinas, participando como investigador asiduo en los Simposios Internacionales “Flavins and Flavoproteins”, en su organización y actualmente pertenezco a su Comité Científico. Actualmente soy miembro de la Junta Directiva de la Sociedad de Biofísica de España y de la Comisión de Investigación de la Universidad de Zaragoza. Actúo como revisor habitual en revistas con revisión por pares, así como para organismos de investigación autonómicos, nacionales e internacionales, y particularmente en los paneles de la AEI. Mi grupo ha sido financiado por diversos proyectos del MINECO, MICINN, AEI, etc.. (IP en 7 proyectos) y programas autonómicos (IP en varios proyectos y financiada como miembro del Grupo de Referencia Biología Estructural). He participado en la CM1103 internacional COST ACTION (2011-2015), en la EU-Interreg-SUDOE (2014-2015), y, actualmente, en el Proyecto PARACAT ITN-Marie Sklodovswka Curie, los tres financiaron por UE. Mantengo colaboraciones de investigación con un importante número de grupos nacionales e internacionales. En los últimos 5 años he colaborado activamente con más de 15 grupos extranjeros (UK, EEUU, Francia, Italia, Alemania, Brasil, Argentina, Holanda, Finlandia, etc…) e investigadores de dichos grupos han realizado estancias en mi grupo. a) 4162 citaciones, 352 citas/año 2017-2022; promedio 22.4 citas/articulo; b) 43 publicaciones 2017-2022, de total 181; c) Índice h 39; d) Dirección 3 tesis doctorales completadas en 2017-2022, de un total de 16, 1 depositada y prevista su defensa en Julio 2023, y 5 en desarrollo; e) 41 capítulos libro; f) 5 sexenios investigación (ultimo Diciembre 2018) y 6 quinquenios docencia; g) Investigador principal de 12 Proyectos de Investigación, 7 del Ministerio Español-AEI (2 iniciados en el periodo 2017-2022), y de 2 Proyectos GA (1 iniciado en periodo 2017-2022); h) Investigador Principal Grupo Referencia Biología Estructural Gobierno de Aragón en periodo 2017-2022; i) 4 conferencias invitadas en Congresos y más de 80 comunicaciones 2017-2022, de un total de 31 y más de 350 respectivamente; j) Dirección de más de 37 Trabajos Fin BSc+MSc y 10 trabajos académicamente dirigidos a estudiantes intercambio. Artículos Curtabbi, Andrea; Guarás, Adela; Cabrera-Alarcón, José Luis; Rivero, Maribel; Calvo, Enrique; Rosa-Moreno, Marina; Vázquez, Jesús; Medina, Milagros; Enríquez, José Antonio. Regulation of respiratory complex I assembly by FMN cofactor targeting. REDOX BIOLOGY. 2024. DOI: 10.1016/j.redox.2023.103001 Rivero, Maribel; Novo, Nerea; Medina, Milagros. Pyridoxal 5'-phosphate biosynthesis by pyridox-(am)-ine 5'-phosphate oxidase: species-specific features. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. DOI: 10.3390/ijms25063174 Grieco, Alice; Boneta, Sergio; Gavira, José A.; Pey, Angel L.; Basu, Shibom; Orlans, Julien; Sanctis, Daniele De; Medina, Milagros; Martin-Garcia, Jose Manuel. Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations. PROTEIN SCIENCE. 2024. DOI: 10.1002/pro.4957 Pacheco-García, Juan Luis; Anoz Carbonell, Ernesto; Loginov, Dmitry S.; Kavan, Daniel; Salido, Eduardo; Man, Petr; Medina, Milagros; Pey, Angel L. Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme. FEBS JOURNAL. 2023. DOI:* 10.1111/febs.16677 Rivero, Maribel; Boneta, Sergio; Novo, Nerea; Velázquez-Campoy, Adrián; Polo, Victor; Medina, Milagros. Riboflavin kinase and pyridoxine 5'-phosphate oxidase complex formation envisages transient interactions for FMN cofactor delivery. FRONTIERS IN MOLECULAR BIOSCIENCES. 2023. DOI: 10.3389/fmolb.2023.1167348 Nisco, Alessia; Carvalho, Tiago M. A.; Tolomeo, Maria; Di Molfetta, Daria; Leone, Piero; Galluccio, Michele; Medina, Milagros; Indiveri, Cesare; Reshkin, Stephan Joel; Cardone, Rosa Angela; Barile, Maria. Increased demand for FAD synthesis in differentiated and stem pancreatic cancer cells is accomplished by modulating FLAD1 gene expression: the inhibitory effect of Chicago Sky Blue. FEBS JOURNAL. 2023. DOI: 10.1111/febs.16881 Minjárez Sáenz, M.; Martínez Júlvez, M.; Yruela, I.; Medina, M. Mining the Flavoproteome of Brucella ovis, the Brucellosis causing agent in Ovis aries. MICROBIOLOGY SPECTRUM. 2022. DOI: 10.1128/spectrum.02294-21 Pérez-Domínguez, S. ; Caballero-Mancebo, S. ; Marcuello, C. ; Martínez-Júlvez, M. ; Medina, M. ; Gracia Lostao, A. Nanomechanical Study of Enzyme: Coenzyme Complexes: Bipartite Sites in Plastidic Ferredoxin-NADP+ Reductase for the Interaction with NADP+. ANTIOXIDANTS. 2022. DOI: 10.3390/antiox11030537 Novo, Nerea; Romero-Tamayo, Silvia; Marcuello, Carlos; Boneta, Sergio; Blasco-Machin, Irene; Velázquez-Campoy, Adrián; Villanueva, Raquel; Moreno-Loshuertos, Raquel; Lostao, Anabel; Medina, Milagros; Ferreira, Patricia. Beyond a platform protein for the degradosome assembly: the apoptosis-inducing factor as an efficient nuclease involved in chromatinolysis. PNAS NEXUS. 2022. DOI: 10.1093/pnasnexus/pgac312 Salido, Eduardo; Timson, David J.; Betancor-Fernández, Isabel; Palomino-Morales, Rogelio; Anoz-Carbonell, Ernesto; Pacheco-García, Juan Luis; Medina, Milagros; Pey, Ángel L. Targeting HIF-1a Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1. JOURNAL OF PERSONALIZED MEDICINE. 2022. DOI: 10.3390/jpm12050747 Pacheco-Garcia, Juan Luis; Anoz Carbonell, Ernesto; Loginov, Dmitry S.; Vankova, Pavla; Salido, Eduardo; Man, Petr; Medina, Milagros; Palomino-Morales, Rogelio; Pey, Angel L. Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2022. DOI: 10.1016/j.abb.2022.109392 Pacheco-Garcia, Juan Luis; Loginov, Dmitry S.; Anoz-Carbonell, Ernesto; Vankova, Pavla; Palomino-Morales, Rogelio; Salido, Eduardo; Man, Petr; Medina, Milagros; Naganathan, Athi N.; Pey, Angel L. Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations. ANTIOXIDANTS. 2022. DOI: 10.3390/antiox11061110 Novo, N.; Ferreira, P.; Medina, M. The apoptosis-inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei. IUBMB LIFE. 2021. DOI: 10.1002/iub.2390 Romero-Tamayo, S.; Laplaza, R.; Velazquez-Campoy, A.; Villanueva, R.; Medina, M.; Ferreira, P. W196 and the ß -Hairpin Motif Modulate the Redox Switch of Conformation and the Biomolecular Interaction Network of the Apoptosis-Inducing Factor. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021. DOI: 10.1155/2021/6673661 Gracia Lostao, Anabel; Medina, Milagros. Atomic Force Microscopy: Single-Molecule Imaging and Force Spectroscopy in the Study of Flavoproteins Ligand Binding and Reaction Mechanisms. METHODS IN MOLECULAR BIOLOGY. 2021. DOI: 10.1007/978-1-0716-1286-6_10 Pacheco-Garcia J.L.; Anoz-Carbonell E.; Vankova P.; Kannan A.; Palomino-Morales R.; Mesa-Torres N.; Salido E.; Man P.; Medina M.; Naganathan A.N.; Pey A.L. Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue. REDOX BIOLOGY. 2021. DOI: 10.1016/j.redox.2021.102112 Marcuello C.; Frempong G.A.; Balsera M.; Medina M.; Lostao A. Atomic force microscopy to elicit conformational transitions of ferredoxin-dependent flavin thioredoxin reductases. ANTIOXIDANTS. 2021. DOI: 10.3390/antiox10091437 Buey R.M.; Fernández-Justel D.; González-Holgado G.; Martínez-Júlvez M.; González-López A.; Velázquez-Campoy A.; Medina M.; Buchanan B.B.; Balsera M. Unexpected diversity of ferredoxin-dependent thioredoxin reductases in cyanobacteria. PLANT PHYSIOLOGY. 2021. DOI: 10.1093/plphys/kiab072 Moreno, Andrea; Taleb, Víctor; Sebastián, María; Anoz-Carbonell, Ernesto; Martinez-Júlvez, Marta; Medina, Milagros. Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis. IUBMB LIFE. 2021. DOI: 10.1002/iub.2576 Ferreira, P.; Medina, M. Anaerobic Stopped-Flow Spectrophotometry with Photodiode Array Detection in the Presteady State: An Application to Elucidate Oxidoreduction Mechanisms in Flavoproteins. METHODS IN MOLECULAR BIOLOGY. 2021. DOI: 10.1007/978-1-0716-1286-6_9 Carro, Juan; Martínez-Julve, Marta; Medina, Milagros; Martínez, Angel T.; Ferreira, Patricia. Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2020. DOI: 10.1039/C7CP05904C Lans, Isaías; Anoz-Carbonell, Ernesto; Palacio-Rodríguez, Karen; Aínsa, José Antonio; Medina, Milagros; Cossio, Pilar. In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target. PLOS COMPUTATIONAL BIOLOGY. 2020. DOI: 10.1371/journal.pcbi.1007898 Anoz-Carbonell, Ernesto; Rivero, Maribel; Polo, Victor; Velázquez-Campoy, Adrián; Medina, Milagros. Human riboflavin kinase: Species-specific traits in the biosynthesis of the FMN cofactor. FASEB JOURNAL. 2020. DOI: 10.1096/fj.202000566r Anoz-Carbonell, E.; Timson, D.J.; Pey, A.L.; Medina, M. The catalytic cycle of the antioxidant and cancer-associated human NQO1 enzyme: Hydride transfer, conformational dynamics and functional cooperativity. ANTIOXIDANTS. 2020. DOI: 10.3390/antiox9090772 Serrano, A.; Arilla-Luna, S.; Medina, M. Insights into the fmnat active site of fad synthase: Aromaticity is essential for flavin binding and catalysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. DOI: 10.3390/ijms21103738 Sebastian, M.;Arilla-Luna, S.;Bellalou, J.;Yruela, I.;Medina, M. The Biosynthesis of Flavin Cofactors in Listeria monocytogenes. JOURNAL OF MOLECULAR BIOLOGY. 2019. DOI: 10.1016/j.jmb.2019.05.029 Villanueva, Raquel; Romero-Tamayo, Silvia; Laplaza, Ruben; Martinez-Olivan, Juan; Velazquez-Campoy, Adrián; Sancho, Javier; Ferreira, Patricia; Medina, Milagros. Redox-and ligand binding-dependent conformational ensembles in the human apoptosis-inducing factor regulate its pro-life and cell death functions. ANTIOXIDANTS & REDOX SIGNALING. 2019. DOI: 10.1089/ars.2018.7658 Leone, Piero; Galluccio, Michele; Quarta, Stefano; Anoz-Carbonell, Ernesto; Medina, Milagros; Indiveri, Cesare; Barile, Maria. Mutation of aspartate 238 in FAD synthase isoform 6 increases the specific activity by weakening the FAD binding. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019. DOI: 10.3390/ijms20246203 Arilla-Luna S.; Serrano A.; Medina M. Specific features for the competent binding of substrates at the FMN adenylyltransferase site of FAD synthase from corynebacterium ammoniagenes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019. DOI: 10.3390/ijms20205083 Lete M.G.; Monasterio B.G.; Collado M.I.; Medina M.; Sot J.; Alonso A.; Goñi F.M. Fast and slow biomembrane solubilizing detergents: Insights into their mechanism of action. COLLOIDS AND SURFACES B-BIOINTERFACES. 2019. DOI: 10.1016/j.colsurfb.2019.110430 Perez-Amigot, Daniel; Taleb, Víctor; Boneta, Sergio; Anoz-Carbonell, Ernesto; Sebastian, María; Velazquez-Campoy, Adrián; Polo, Víctor; Martinez-Julvez, Marta; Medina, Milagros. Towards the competent conformation for catalysis in the ferredoxin-NADP(+) reductase from the Brucella ovis pathogen. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2019. DOI: 10.1016/j.bbabio.2019.148058 Sebastián, M.; Anoz-Carbonell, E.; Gracia, B.; Cossio, P.; Aínsa, J.A.; Lans, I.; Medina, M. Discovery of antimicrobial compounds targeting bacterial type FAD synthetases. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2018. DOI: 10.1080/14756366.2017.1411910 Martínez-Júlvez, M.; Goñi, G.; Pérez-Amigot, D.; Laplaza, R.; Ionescu, I.A.; Petrocelli, S.; Tondo, M.L.; Sancho, J.; Orellano, E.G.; Medina, M. Identification of inhibitors targeting ferredoxin-NADP+ reductase from the xanthomonas citri subsp. Citri phytopathogenic bacteria. MOLECULES. 2018. DOI: 10.3390/molecules23010029 Lans, I.; Seco, J.; Serrano, A.; Burbano, R.; Cossio, P.; Daza, M.C.; Medina, M. The Dimer-of-Trimers Assembly Prevents Catalysis at the Transferase Site of Prokaryotic FAD Synthase. BIOPHYSICAL JOURNAL. 2018. DOI: 10.1016/j.bpj.2018.08.011 Carro, Juan; Amengual-Rigo, Pep; Ferran, Sancho; Medina, Milagros; Guallar, Victor; Ferreira, Patricia; Martínez, T. Angel. Multiple implications of an active site phenylalanine in the catalysis of aryl-alcohol oxidase. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2018. DOI: 10.1038/s41598-018-26445-x Sebastián, M.; Velázquez-Campoy, A.; Medina, M. The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2018. DOI: 10.1080/14756366.2018.1461857 Koskela, M.M.; Dahlström, K.M.; Goñi, G.; Lehtimäki, N.; Nurmi, M.; Velazquez-Campoy, A.; Hanke, G.; Bölter, B.; Salminen, T.A.; Medina, M.; Mulo, P. Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP+ reductases. PHYSIOLOGIA PLANTARUM. 2018. DOI: 10.1111/ppl.12621 Lamazares, E.; Vega, S.; Ferreira, P.; Medina, M.; Galano-Frutos, J.J.; Martínez-Júlvez, M.; Velázquez-Campoy, A.; Sancho, J. Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2017. DOI: 10.1039/c7cp02606d Huijbers, M. M. E.; Martínez-Júlvez, M.; Westphal, A. H.; Delgado-Arciniega, E.; Medina, M.; Van Berkel, W. J. H. Proline dehydrogenase from Thermus thermophilus does not discriminate between FAD and FMN as cofactor. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/srep43880 Sebastián, María; Lira-Navarrete, Erandi; Serrano, Ana; Marcuello, Carlos; Velázquez-Campoy, Adrián; Lostao, Anabel; Hurtado-Guerrero, Ramón; Medina, Milagros; Martínez-Júlvez, Marta. The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-07716-5 Serrano, A.; Sebastián, M.; Arilla-Luna, S.; Baquedano, S.; Herguedas, B.; Velázquez-Campoy, A.; Martínez-Júlvez, M.; Medina, M. The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-00402-6 Sebastián, M.; Serrano, A.; Velázquez-Campoy, A.; Medina, M. Kinetics and thermodynamics of the protein-ligand interactions in the riboflavin kinase activity of the FAD synthetase from Corynebacterium ammoniagenes. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2017. DOI: 10.1038/s41598-017-07875-5 Mulo, P.; Medina, M. Interaction and electron transfer between ferredoxin–NADP+ oxidoreductase and its partners: structural, functional, and physiological implications. PHOTOSYNTHESIS RESEARCH. 2017. DOI: 10.1007/s11120-017-0372-0 Martínez,J. I.;Frago,S.;Lans,I.;Alonso,P. J.;García-Rubio,I.;Medina,M. Spin Densities in Flavin Analogs within a Flavoprotein. BIOPHYSICAL JOURNAL. 2016. DOI: 10.1016/j.bpj.2015.11.3525 Ramsay, R.R.; Majekova, M.; Medina, M.; Valoti, M. Key targets for multi-target ligands designed to combat neurodegeneration. FRONTIERS IN NEUROSCIENCE. 2016. DOI: 10.3389/fnins.2016.00375 Ledesma-Garciá, L.; Sánchez-Azqueta, A.; Medina, M.; Reyes-Ramírez, F.; Santero, E. Redox proteins of hydroxylating bacterial dioxygenases establish a regulatory cascade that prevents gratuitous induction of tetralin biodegradation genes. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2016. DOI: 10.1038/srep23848 Garma, L. D.; Medina, M.; Juffer, A. H. Structure-based classification of FAD binding sites: A comparative study of structural alignment tools. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2016. DOI: 10.1002/prot.25158 Reis, Renata A.G.; Ferreira, Patricia; Medina, Milagros; Nonato, M. Cristina. The mechanistic study of Leishmania major dihydro-orotate dehydrogenase based on steady- and pre-steady-state kinetic analysis. BIOCHEMICAL JOURNAL. 2016. DOI: 10.1042/bj20150921 Lete,M. G.; Sot,J.; Gil,D.; Valle,M.; Medina,M.; Goñi,F. M.; Alonso,A. Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate. BIOPHYSICAL JOURNAL. 2015. DOI: 10.1016/j.bpj.2014.12.018 Serrano, A.;Sebastián, M.;Arilla-Luna, S.;Baquedano, S.;Pallarés, M. C.;Lostao, A.;Herguedas, B.;Velázquez-Campoy, A.;Martínez-Júlvez, M.;Medina, M. Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2015. DOI: 10.1016/j.bbapap.2015.03.005 Herguedas, Beatriz; Lans, Isaías; Sebastián, María; Hermoso, Juan; Martínez-Júlvez, Marta; Medina, Milagros. Structural insights into the synthesis of FMN in prokaryotic organisms. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. 2015. DOI: 10.1107/S1399004715019641 Saen-Oon, S.; Vaca, Cabeza De; Masone, D.; Medina, M.; Guallar, V. A theoretical multiscale treatment of protein-protein electron transfer: The ferredoxin/ferredoxin-NADP+ reductase and flavodoxin/ferredoxin-NADP+ reductase systems. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2015. DOI: 10.1016/j.bbabio.2015.09.002 Villanueva, R.; Ferreira, P.; Marcuello, C.; Usón, A.; Miramar, M. D.; Peleato, M. L.; Lostao, A.; Susin, S. A.; Medina, M. Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor. BIOCHEMISTRY. 2015. DOI: 10.1021/acs.biochem.5b00696 Ferreira, P.; Hernández-Ortega, A.; Lucas, F.; Carro, J.; Herguedas, B.; Borrelli, K. W.; Guallar, V.; Martínez, A. T.; Medina, M. Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase. FEBS JOURNAL. 2015. DOI: 10.1111/febs.13221 Antonini, L.V.; Peregrina, J.R.; Angulo, J.; Medina, M.; Nieto, P.M. A STD-NMR study of the interaction of the Anabaena Ferredoxin-NAD P+ reductase with the Coenzyme. MOLECULES. 2014. DOI: 10.3390/molecules19010672 Martínez Martínez, Jesús Ignacio; Alonso Gascón, Pablo Javier; García-Rubio, Inés; Medina Trullenque, Milagros. Methyl rotors in flavoproteins. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2014. DOI: 10.1039/c4cp03115f Sánchez-Azqueta,A.; Catalano-Dupuy,D.; López-Rivero,A.; Tondo,M. L.; Orellano,E. G.; Ceccarelli,E. A.; Medina,M. Dynamics of the active site architecture in plant-type ferredoxin-NADP + reductases catalytic complexes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2014. DOI: 10.1016/j.bbabio.2014.06.003 Ferreira, Patricia; Martínez-Júlvez, Marta; Medina, Milagros. Electron Transferases. METHODS IN MOLECULAR BIOLOGY. 2014. DOI: 10.1007/978-1-4939-0452-5_5 Sánchez-Azqueta,A.; Herguedas,B.; Hurtado-Guerrero,R.; Hervás,M.; Navarro,J. A.; Martínez-Júlvez,M.; Medina,M. A hydrogen bond network in the active site of Anabaena ferredoxin-NADP + reductase modulates its catalytic efficiency. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2014. DOI: 10.1016/j.bbabio.2013.10.010 Sánchez-Azqueta,A.; Martínez-Júlvez,M.; Hervás,M.; Navarro,J. A.; Medina,M. External loops at the ferredoxin-NADP+ reductase protein-partner binding cavity contribute to substrates allocation. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2014. DOI: 10.1016/j.bbabio.2013.11.016 Bortolotti, A.; Sánchez-Azqueta, A.; Maya, C.M.; Velázquez-Campoy, A.; Hermoso, J. A.; Medina, M.; Cortez, N. The C-terminal extension of bacterial flavodoxin-reductases: Involvement in the hydride transfer mechanism from the coenzyme. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2014. DOI: 10.1016/j.bbabio.2013.08.008 Ferreira, P; Villanueva, R; Martínez-Júlvez, M; Herguedas, B; Marcuello, C; Fernandez-Silva, P; Cabon, L; Hermoso, J.A.; Lostao, A; Susin, S.A.; Medina, M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic Apoptosis Inducing Factor. BIOCHEMISTRY. 2014. DOI: 10.1021/bi500343r Medina, M.;Ferreira, P.;Martínez-Júlvez, M. Flavoproteins and flavoenzymes with biomedical and therapeutic impact. CURRENT PHARMACEUTICAL DESIGN. 2013. DOI: 10.2174/1381612811319140001 Hervás,M.;Bashir,Q.;Leferink,N. G. H.;Ferreira,P.;Moreno-Beltrán,B.;Westphal,A. H.;Díaz-Moreno,I.;Medina,M.;Rosa,de La;Ubbink,M.;Navarro,J. A.;Van Berkel,W. J. H. Communication between L-galactono-1,4-lactone dehydrogenase and cytochrome c. FEBS JOURNAL. 2013. DOI: 10.1111/febs.12207 Prado, S.;Villarroya, M.;Medina, M.;Armengod, M. -E. The tRNA-modifying function of MnmE is controlled by post-hydrolysis steps of its GTPase cycle. NUCLEIC ACIDS RESEARCH. 2013. DOI: 10.1093/nar/gkt320 Serrano, A.; Ferreira, P.; Martinez Júlvez, M.; Medina, M. The prokaryotic FAD synthetase family: a potential drug target. CURRENT PHARMACEUTICAL DESIGN. 2013 Tondo, M.L.; Hurtado-Guerrero, R.; Ceccarelli, E.A.; Medina, M.; Orellano, E.G.; Martínez-Júlvez, M. Crystal structure of the FAD-containing ferredoxin-NADP+ reductase from the plant pathogen Xanthomonas axonopodis pv. citri. BIOMED RESEARCH INTERNATIONAL. 2013. DOI: 10.1155/2013/906572 Serrano,A.; Frago,S.; Herguedas,B.; Martinez-Julvez,M.; Velazquez-Campoy,A.; Medina,M. Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/FMN Adenylyltransferase From Corynebacterium ammoniagenes. CELL BIOCHEMISTRY AND BIOPHYSICS. 2013. DOI: 10.1007/s12013-012-9403-9 Ferreira, Patricia; Villanueva, Raquel; Cabon, Lauriane; Susin, Santos A.; Medina, Milagros. The oxido-reductase activity of the apoptosis inducing factor: a promising pharmacological tool?. CURRENT PHARMACEUTICAL DESIGN. 2013 Marcuello,C.;Arilla-Luna,S.;Medina,M.;Lostao,A. Detection of a quaternary organization into dimer of trimers of Corynebacterium ammoniagenes FAD synthetase at the single-molecule level and at the in cell level. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2013. DOI: 10.1016/j.bbapap.2012.12.013 Hernâ·ndez-Ortega, A.;Ferreira, P.;Merino, P.;Medina, M.;Guallar, V.;Martãœnez, A. T. Stereoselective hydride transfer by aryl-alcohol oxidase, a member of the GMC superfamily. CHEMBIOCHEM. 2012. DOI: 10.1002/cbic.201100709 Peregrina, J.R.;Lans, I.;Medina, M. The transient catalytically competent coenzyme allocation into the active site of Anabaena ferredoxin NADP +-reductase. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2012. DOI: 10.1007/s00249-011-0704-5 Martinez-Julvez,M.;Abian,O.;Vega,S.;Medina,M.;Velazquez-Campoy,A. Studying the allosteric energy cycle by isothermal titration calorimetry. METHODS IN MOLECULAR BIOLOGY. 2012. DOI: 10.1007/978-1-61779-334-9_4 Sánchez-Azqueta,A.;Musumeci,M. A.;Martínez-Júlvez,M.;Ceccarelli,E. A.;Medina,M. Structural backgrounds for the formation of a catalytically competent complex with NADP(H) during hydride transfer in ferredoxin-NADP + reductases. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2012. DOI: 10.1016/j.bbabio.2012.04.009 Serrano, A; Frago, S; Velázquez-Campoy, A; Medina, M. Role of Key Residues at the Flavin Mononucleotide (FMN):Adenylyltransferase Catalytic Site of the Bifunctional Riboflavin Kinase/Flavin Adenine Dinucleotide (FAD) Synthetase from Corynebacterium ammoniagenes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2012. DOI: 10.3390/ijms131114492 Marcuello, C.; Arilla-Luna, S.; Medina, M.; Lostao, A. Atomic force microscopy reveals a dimer of trimers organization in Corynebacterium ammoniagenes FAD synthetase FEBS JOURNAL. 2012 Hernández-Ortega, Aitor; Lucas, Fátima; Ferreira, Patricia; Medina, Milagros; Guallar, Victor; Martinez, Angel T. . Role of Active Site Histidines in the Two Half-Reactions of the Aryl-Alcohol Oxidase Catalytic Cycle. BIOCHEMISTRY. 2012. DOI: 10.1021/bi300505z Lans,I.;Frago,S.;Medina,M. Understanding the FMN cofactor chemistry within the Anabaena Flavodoxin environment. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2012. DOI: 10.1016/j.bbabio.2012.08.008 Lans,I.;Medina,M.;Rosta,E.;Hummer,G.;Garcia-Viloca,M.;Lluch,J. M.;González-Lafont,A. Theoretical study of the mechanism of the hydride transfer between ferredoxin-NADP+ reductase and NADP+: The role of Tyr303. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2012. DOI: 10.1021/ja310331v Marcuello, C.; de Miguel, R.; Medina, M.; Martínez-Júlvez, M.; Gómez-Moreno, G.; Lostao, A. Nanomechanics of ferredoxin-NADP+ reductase complexes analyzed by AFM single-molecule force spectroscopy. FEBS JOURNAL. 2012 Martínez,J. I.;Alonso,P. J.;Medina,M. The electronic structure of the neutral isoalloxazine semiquinone within Anabaena flavodoxin: New insights from HYSCORE experiments. JOURNAL OF MAGNETIC RESONANCE. 2012. DOI: 10.1016/j.jmr.2012.02.011 Sagasti, S.;Yruela, I.;Bernal, M.;Lujan, M. A.;Frago, S.;Medina, M. ;Picorel, R. Characterization of the recombinant copper chaperone (CCS) from the plant Glycine (G.) max. METALLOMICS. 2011. DOI: 10.1039/c0mt00055h Ceccoli,R. D.;Blanco,N. E.;Medina,M.;Carrillo,N. Stress response of transgenic tobacco plants expressing a cyanobacterial ferredoxin in chloroplasts. PLANT MOLECULAR BIOLOGY. 2011. DOI: 10.1007/s11103-011-9786-9 Hernández-Ortega,A.;Lucas,F.;Ferreira,P.;Medina,M.;Guallar,V.;Martínez,A. T. Modulating O2 reactivity in a fungal flavoenzyme: Involvement of aryl-alcohol oxidase Phe-501 contiguous to catalytic histidine. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. DOI: 10.1074/jbc.M111.282467 Hernández-Ortega, A.;Borrelli, K.;Ferreira, P.;Medina, M.;Martínez, A. T. ;Guallar, V. Substrate diffusion and oxidation in GMC oxidoreductases: An experimental and computational study on fungal aryl-alcohol oxidase. BIOCHEMICAL JOURNAL. 2011 Frago, S.;Lans, I.;Navarro, J. A.;Hervas, M.;Edmondson, D. E.;de la Rosa, M. A.;Gomez-Moreno, C.;Mayhew, S. G. ;Medina, M. Dual role of FMN in flavodoxin function: Electron transfer cofactor and modulation of the protein-protein interaction surface. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2010 Ferreira, P.; Hernandez-Ortega, A.; Herguedas, B.; Rencoret, J.; Gutierrez, A.; Martinez, M. J.; Jimenez-Barbero, J.; Medina, M.; Martinez, A. T. Kinetic and chemical characterization of aldehyde oxidation by fungal aryl-alcohol oxidase. BIOCHEMICAL JOURNAL. 2010. DOI: 10.1042/BJ20091499 Yruela, Inmaculada; Arilla, Sonia; Medina, Milagros; Contreras, Bruno. Evolutionary divergence of chloroplast FAD synthetase proteins. BMC STRUCTURAL BIOLOGY. 2010. DOI: 10.1186/1471-2148-10-311 Lans, I.;Peregrina, J. R.;Medina, M.;Garcia-Viloca, M.;Gonzalez-Lafont, A. ;Lluch, J. M. Mechanism of the hydride transfer between anabaena Tyr303Ser FNR rd/FNR0x and NADP+/H. A combined pre-steady-state Kinetic/Ensemble-averaged transition-state theory with multidimensional tunneling study. JOURNAL OF PHYSICAL CHEMISTRY. B. 2010 Herguedas Beatriz; Martínez-Júlvez Marta; Frago Susana; Medina Milagros; Hermoso Juan A. Oligomeric state in the crystal structure of modular FAD synthetase provides insights into its sequential catalysis in prokaryotes. JOURNAL OF MOLECULAR BIOLOGY. 2010. DOI: 10.1016/j.jmb.2010.05.018 Peregrina, J. R.;Sanchez-Azqueta, A.;Herguedas, B.;Martinez-Julvez, M. ;Medina, M. Role of specific residues in coenzyme binding, charge-transfer complex formation, and catalysis in Anabaena ferredoxin NADP+-reductase. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2010 Goñí, Guillermina; Herguedas, Beatriz; Hervás, Manuel; Peregrina, José R.; de la Rosa, Miguel A.; Gómez-Moreno, Carlos; Navarro, José A.; Hermoso, Juan A.; Martínez-Júlvez, Marta; Medina, Milagros . Flavodoxin: A compromise between efficiency and versatility in the electron transfer from Photosystem I to Ferredoxin-NADP(+) reductase. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2009. DOI: 10.1016/j.bbabio.2008.12.006 Bortolotti, Aana; Pérez-Dorado, Inmaculada; Goñi, Guillermina; Medina, Milagros; Hermoso, Juan A.; Carrillo, Néstor; Cortez, Néstor. Coenzyme binding and hydride transfer in Rhodobacter capsulatus ferredoxin/flavodoxin NADP(H) oxidoreductase. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2009 Garcia-Rubio, Inés; Alonso, Pablo J.; Medina, Milagros; Martínez, Jesús I. HYSCORE AND ESEEM STUDY OF THE TWO COEXISTING FORMS OF THE HEMEPROTEIN CYTOCHROME C6 FROM ANABAENA PCC7119. BIOPHYSICAL JOURNAL. 2009 Frago, S.;Velazquez-Campoy,A.;Medina,M. The Puzzle of Ligand Binding to Corynebacterium Ammoniagenes FAD Synthetase. JOURNAL OF BIOLOGICAL CHEMISTRY. 2009 Herguedas, B.;Martinez-Julvez,M.;Frago,S.;Medina,M.;Hermoso,J. A. Crystallization and Preliminary X-Ray Diffraction Studies of FAD Synthetase from Corynebacterium Ammoniagenes. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009 Goi, G;Zoellner, A;Lisurek, M;Velazquez-Campoy, A;Pinto, S;Gomez-Moreno, C;Hannemann, F;Bernhardt, R;Medina, M. Cyanobacterial Electron Carrier Proteins as Electron Donors to CYP106A2 from Bacillus Megaterium ATCC 13368. BIOCHIMICA ET BIOPHYSICA ACTA - PROTEINS AND PROTEOMICS. 2009 Martinez-Julvez, M.; Medina, M.; Velazquez-Campoy, A. Binding thermodynamics of ferredoxin:NADP+ reductase: Two different protein substrates and one energetics. BIOPHYSICAL JOURNAL. 2009. DOI: 10.1016/j.bpj.2009.02.061 Medina, Milagros. Structural and Mechanistic Aspects of Flavoproteins: Photosynthetic Electron Transfer from Photosystem I to NADP+. FEBS JOURNAL. 2009 Peregrina, José R.; Herguedas, Beatriz; Hermoso, Juan A.; Martínez-Júlvez, Marta; Medina, Milagros. Protein Motifs Involved in Coenzyme Interaction and Enzymatic Efficiency in Anabaena Ferredoxin-NADP+ Reductase. BIOCHEMISTRY. 2009. DOI: 10.1021/bi802077c Ferreira, Patricia; Hernández-Ortega, Aitor; Herguedas, Beatriz; Martínez, Ángel T.; Medina, Milagros. Aryl-alcohol oxidase involved in lignin degradation. A mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates. JOURNAL OF BIOLOGICAL CHEMISTRY. 2009. DOI: 10.1074/jbc.M109.011593 García-Rubio, Inés; Alonso, Pablo J.; Medina, Milagros; Martínez, Jesús I. Hyperfine Correlation Spectroscopy and Electron Spin Echo Envelope Modulation Spectroscopy Study of the Two Coexisting Forms of the Hemeprotein Cytochrome c6 from Anabaena Pcc7119. BIOPHYSICAL JOURNAL. 2009. DOI: 10.1529/biophysj.108.133272 Medina, Milagros; Abagyan, Ruben; Gómez-Moreno, Carlos; Fernandez-Recio, Juan. Docking analysis of transitent complexes: Interaction of Ferredoxin-NADP+ Reductase with Ferredoxin and Flavodoxin. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2008 Goni, G;Serrano, A;Frago, S;Hervas, M;Peregrina, J.R;Rosa, D.L;Gomez-Moreno, C;Navarro, J.A;Medina, M. Flavodoxin-Mediated Electron Transfer from Photosystem I to Ferredoxin-NADP+ Reductase in Anabaena: Role of Flavodoxin Hydrophobic Residues in Protein-Protein Interactions. BIOCHEMISTRY. 2008 Frago, S.;Martinez-Julvez,M.;Serrano,A.;Medina,M. Structural Analysis of FAD Synthetase from Corynebacterium Ammoniagenes. BMC MICROBIOLOGY. 2008 Frago, Susana; Goñi, Guillermina; Herguedas, Beatriz; Peregrina, Jose Ramon; Serrano , Ana; Perez-Dorado, Inmaculada; Molina, Rafael; Gomez-Moreno, Carlos; Hermoso, Juan A.; Martinez-Julvez, Marta; Mayhew, Stephen G.; Medina, Milagros. Tuning of the FMN Binding and Oxido-Reduction Properties by Neighboring Side Chains in Anabaena Flavodoxin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007. DOI: 10.1016/j.abb.2007.08.024 Medina, Milagros; Cammack, Richard. ENDOR and related EMR methods applied to flavoprotein radicals. APPLIED MAGNETIC RESONANCE. 2007 Tejero, Jesús; Peregrina, José Ramón; Martínez-Júlvez, Marta; Gutiérrez, Aldo; Scrutton, Nigel S.; Gómez-Moreno, Carlos; Medina, Milagros. Catalytic mechanism of the hydride transfer between NADP+/H and Ferredoxin NADP+-reductase from Anabaena PCC 7119. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007 Luisa Schubert; Susana Frago; Marta Martínez-Júlvez; Milagros Medina Sequence and Phylogenetic Analysis of FAD Synthetase. AIP CONFERENCE PROCEEDINGS. 2006. DOI: 10.1063/1.2345635 Sánchez,I. E.;Tejero,J.;Gomez-Moreno,C.;Medina,M.;Serrano,L. Point mutations in protein globular domains: Contributions from function, stability and misfolding. JOURNAL OF MOLECULAR BIOLOGY. 2006 Garcia Rubio,Ines; Medina,Milagros; Cammack,Richard; Alonso,Pablo J.; Martinez,Jesus I. CW-EPR and ENDOR study of cytochrome c(6) from Anabaena PCC 7119. BIOPHYSICAL JOURNAL. 2006. DOI: 10.1529/biophysj.105.080358 Velazquez Campoy,Adrian;Goni,Guillermina;Peregrina,Jose Ramon;Medina,Milagros. Exact analysis of heterotropic interactions in proteins: Characterization of cooperative ligand binding by isothermal titration calorimetry. BIOPHYSICAL JOURNAL. 2006 Tejero, Jesus;Perez Dorado, Inmaculada;Maya, Celia;Martinez Julvez, Marta;Sanz Aparicio, Julia;Gomez Moreno, Carlos;Hermoso, Juan A;Medina, Milagros. C-terminal tyrosine of ferredoxin-NADP+ reductase in hydride transfer processes with NAD(P)+/H. BIOCHEMISTRY. 2005 Nogues, Isabel;Hervas, Manuel;Peregrina, Jose R;Navarro, Jose A;Rosa, Miguel A.de La;Gomez Moreno, Carlos;Medina, Milagros. Anabaena flavodoxin as an electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of flavodoxin residues in protein - Protein interaction and electron transfer. BIOCHEMISTRY. 2005 Nogues, I;Perez Dorado, I;Frago, S;Bittel, C;Mayhew, S.G;Gomez Moreno, C;Hermoso, J.A;Medina, M;Cortez, N;Carrillo, N. The Ferredoxin-Nadp(H) Reductase From Rhodobacter Capsulatus: Molecular Structure and Catalytic Mechanism. BIOCHEMISTRY. 2005 Ferreira, P.;Medina, M.;Guillen, F.;Martinez, M. J.;Van Berkel, W. J. H.;Martinez, A. T. Spectral and Catalytic Properties of Aryl-Alcohol Oxidase, a Fungal Flavoenzyme Acting on Polyunsaturated Alcohols. BIOCHEMICAL JOURNAL. 2005 Martinez Julvez, M;Tejero, J;Peregrina, J.R;Nogues, I;Frago, S;Gomez Moreno, C;Medina, M. Towards a New Interaction Enzyme : Coenzyme. BIOPHYSICAL CHEMISTRY. 2005 Anusevicius, Z.;Miseviciene, L.;Medina, M.;Martinez Julvez, M.;Gomez Moreno, C.;Cenas, N. Fad Semiquinone Stability Regulates Single- and Two-Electron Reduction of Quinones by Anabaena Pcc7119 Ferredoxin : Nadp(+) Reductase and Its Glu301ala Mutant. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2005 Mayoral, T;Martinez Julvez, M;Perez Dorado, I;Sanz Aparicio, J;Gomez Moreno, C;Medina, M;Hermoso, J.A. Structural Analysis of Interactions for Complex Formation Between Ferredoxin-Nadp(+) Reductase and Its Protein Partners. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2005 Zollner, A.;Nogues, I.;Heinz, A.;Medina, M.;Gomez Moreno, C.;Bernhardt, R. Analysis of the Interaction of a Hybrid System Consisting of Bovine Adrenodoxin Reductase and Flavodoxin From the Cyanobacterium Anabaena Pcc 7119. BIOELECTROCHEMISTRY. 2004 Sarlauskas, J. ; Nemeikaite-Ceniene, A. ; Anusevicius, Z. ; Miseviciene, L. ; Martínez-Julvez, M. ; Medina, M. ; Gomez-Moreno, C. ; Cenas, N. . Flavoenzyme-Catalyzed Redox Cycling of Hydroxylamino and Amino Metabolites of 2,4,6-Trinitrotoluene: Implications for Their Cytotoxicity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2004 Nogues, I.;Tejero, J.;Hurley, J. K.;Paladini, D.;Frago, S.;Tollin, G.;Mayhew, S. G.;Gomez Moreno, C.;Ceccarelli, E. A.;Carrillo, N.;Medina, M. Role of the C-Terminal Tyrosine of Ferredoxin-Nicotinamide Adenine Dinucleotide Phosphate Reductase in the Electron Transfer Processes With Its Protein Partners Ferredoxin and Flavodoxin. BIOCHEMISTRY. 2004. DOI: 10.1021/bi049858h Medina, M.;Gomez Moreno, C. Interaction of Ferredoxin-Nadp(+) Reductase With Its Substrates: Optimal Interaction for Efficient Electron Transfer. PHOTOSYNTHESIS RESEARCH. 2004 Nogues, Isabel;Campos, Luis Alberto;Sancho, Javier;Gomez Moreno, Carlos;Mayhew, Stephen G.;Medina, Milagros. Role of neighboring FMN side chains in the modulation of flavin reduction potentials and in the energetics of the FMN:apoprotein interaction in Anabaena flavodoxin. BIOCHEMISTRY. 2004 Nogues, I.;Martinez Julvez, M.;Navarro, J. A.;Hervas, M.;Armenteros, L.;de la Rosa, M. A.;Brodie, T. B.;Hurley, J. K.;Tollin, G.;Gomez-Moreno, C.;Medina, M. Role of Hydrophobic Interactions in the Flavodoxin Mediated Electron Transfer From Photosystem I to Ferredoxin-Nadp(+) Reductase in Anabaena Pcc 7119. BIOCHEMISTRY. 2003 Tejero, J.;Martinez-Julvez, M.;Mayoral, T.;Luquita, A.;Sanz-Aparicio, J.;Hermoso, J. A.;Hurley, J. K.;Tollin, G.;Gomez-Moreno, C.;Medina, M. Involvement of the Pyrophosphate and the 2 '-Phosphate Binding Regions of Ferredoxin-Nadp(+) Reductase in Coenzyme Specificity. JOURNAL OF BIOLOGICAL CHEMISTRY. 2003 Faro, M.;Schiffler, B.;Heinz, A.;Nogues, I.;Medina, M.;Bernhardt, R.;Gomez-Moreno, C. Insights Into the Design of a Hybrid System Between Anabaena Ferredoxin-Nadp(+) Reductase and Bovine Adrenodoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2003 Bes, M. T.;Sancho, J.;Peleato, M. L.;Medina, M.;Gomez-Moreno, C.;Fillat, M. F. Purification of Colored Photosynthetic Proteins for Understanding Protein Isolation Principles. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2003 Casaus, Jose, L.;Navarro, Jose, A.;Hervas, Manuel;Lostao, Anabel;de la Rosa, Miguel, A.;Gomez Moreno, Carlos;Sancho, Javier;Medina, Milagros. Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of Trp(57) and Tyr(94). JOURNAL OF BIOLOGICAL CHEMISTRY. 2002 Garcia, Jose I.;Medina, Milagros;Sancho, Javier;Alonso, Pablo J.;Gomez-Moreno, Carlos;Mayoral, Jose A.;Martinez, Jesus I. Theoretical Analysis of the Electron Spin Density Distribution of the Flavin Semiquinone Isoalloxazine Ring within Model Protein Environments. JOURNAL OF PHYSICAL CHEMISTRY A. 2002 Faro, Merche;Gomez, Moreno Carlos;Stankovich, Marian;Medina, Milagros. Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase. Differential stabilization of FAD redox forms. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2002 Hermoso, Juan A.;Mayoral, Tomas;Faro, Merche;Gomez-Moreno, Carlos;Sanz-Aparicio, Julia;Medina, Milagros. Mechanism of Coenzyme Recognition and Binding Revealed by Crystal Structure Analysis of Ferredoxin-NADP+ Reductase Complexed with NADP+. JOURNAL OF MOLECULAR BIOLOGY. 2002. DOI: 10.1016/S0022-2836(02)00388-1 Hurley, John K.;Morales, Renaud;Martinez-Julvez, Marta;Brodie, Tammy B.;Medina, Milagros;Gomez-Moreno, Carlos;Tollin, Gordon. Structure-function relationships in Anabaena ferredoxin/ferredoxin:NADP+ reductase electron transfer: insights from site-directed mutagenesis, transient absorption spectroscopy and X-ray crystallography. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2002 Faro, M. ;Hurley, J. K;Medina, M. ;Tollin, G. ;Gomez Moreno, C. Flavin photochemistry in the analysis of electron transfer reactions: role of charged and hydrophobic residues at the carboxyl terminus of ferredoxin-NADP(+) reductase in the interaction with its substrates. BIOELECTROCHEMISTRY. 2002 Faro, Merche; Frago, Susana; Mayoral, Tomas; Hermoso, Juan A; Sanz, Aparicio Julia; Gomez, Moreno Carlos; Medina, Milagros. Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2002 Medina, M;Luquita, A;Tejero, J;Hermoso, J;Mayoral, T;Sanz Aparicio, J;Grever, K;Gomez Moreno, C. Probing the determinants of coenzyme specificity in ferredoxin-NADP+ reductase by site-directed mutagenesis. JOURNAL OF BIOLOGICAL CHEMISTRY. 2001 Martinez Julvez, M;Nogues, I;Faro, M;Hurley, J.K;Brodie, T.B;Mayoral, T;Sanz Aparicio, J;Hermoso, J.A;Stankovich, M.T;Medina, M;Tollin, G;Gomez Moreno, C. Role of a cluster of hydrophobic residues near the FAD cofactor in Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal complex formation and electron transfer to ferredoxin. JOURNAL OF BIOLOGICAL CHEMISTRY. 2001 Mayoral, T.;Medina, M.;Sanzaparicio, J.;Gomezmoreno, C.;Hermoso, J.A. Structural Basis of the Catalytic Role of Glu301 in Anabaena PCC-7119 Ferredoxin-NADP(+) Reductase Revealed by X-Ray Crystallography. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2000 Morales, R.; Charon, M.-H.; Kachalova, G.; Serre, L.; Medina, M.; Gomez-Moreno, C.; Frey, M. A redox-dependent interaction between two electron-transfer partners involved in photosynthesis. EMBO REPORTS. 2000 Hurley, J.K.;Faro, M.;Brodie, T.B.;Hazzard, J.T.;Medina, M.;Gomezmoreno, C.;Tollin, G. Highly Nonproductive Complexes with Anabaena Ferredoxin at Low Ionic-Strength Are Induced by Nonconservative Amino-Acid Substitutions at Glu139 in Anabaena Ferredoxin-NADP(+) Reductase. BIOCHEMISTRY. 2000 Martinez-Julvez, M.;Medina, M.;Gomez-Moreno, C. Ferredoxin-NADP(+) reductase uses the same site for the interaction with ferredoxin and flavodoxin. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 1999. DOI: 10.1007/s007750050379 Morales, R.;Charon, M. H.;Hudry-Clergeon, G.;Petillot, Y.;Norager, S.;Medina, M.;Frey, M. Refined X-ray structures of the oxidized, at 1.3 angstrom, and reduced, at 1.17 angstrom, [2Fe-2S] ferredoxin from the cyanobacterium Anabaena PCC7119 show redox-linked conformational changes. BIOCHEMISTRY. 1999 Medina, M.; Lostao, A.; Sancho, J.; Gomez-Moreno, C.; Cammack, R.; Alonso, P. J.; Martinez, J. I. Electron-nuclear double resonance and hyperfine sublevel correlation spectroscopic studies of flavodoxin mutants from Anabaena sp PCC 7119. BIOPHYSICAL JOURNAL. 1999 Hurley, J.; Hazzard, J.T.; Martínez-Júlvez, M.; Medina, M.; Gomez-Moreno, C.; Tollin, G. Electrostatic forces involved in orienting Anabaena ferredoxin during binding to Anabaena ferredoxin:NADP+ reductase: site-specific mutagenesis, transient kinetic measurements, and electrostatic surface potentials. PROTEIN SCIENCE. 1999 Medina, M.;Martinez-Julvez, M.;Hurley, J. K.;Tollin, G.;Gomez-Moreno, C. Involvement of glutamic acid 301 in the catalytic mechanism of ferredoxin-NADP(+) reductase from Anabaena PCC 7119. BIOCHEMISTRY. 1998 Gomez-Moreno, C.;Martinez-Julvez, M.;Medina, M.;Hurley, J. K.;Tollin, G. Protein-protein interaction in electron transfer reactions: The ferredoxin/flavodoxin. BIOCHIMIE. 1998. DOI: 10.1016/S0300-9084(00)88878-1 Martínez-Júlvez, M; Medina, M; Hurley, Jk; Hafezi, R; Brodie, Tb; Tollin, G; Gómez-Moreno, C. LYS-75 of Anabaena ferredoxin : NADP(+) reductase is a critical residue for binding ferredoxin during electron transfer. BIOPHYSICAL JOURNAL. 1998. DOI: 10.1021/bi9807411 Martinez-Julvez, M.;Medina, M.;Hurley, J. K.;Hafezi, R.;Brodie, T. B.;Tollin, G.;Gomez-Moreno, C. Lys75 of Anabaena ferredoxin-NADP(+) reductase is a critical residue for binding ferredoxin and flavodoxin during electron transfer. BIOCHEMISTRY. 1998 Louro, R. O.;Aguiar, A. P.;de la Rosa, M.;Turner, D. L.;Medina, M.;Hervas, M.;Gomez-Moreno, C.;Xavier, A. V. Structural and magnetic characterisation of the haem core of ferricytochromes c(6). JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 1998. DOI: 10.1007/s007750050208 Martinez-Julvez, M.;Hermoso, J.;Hurley, J. K.;Mayoral, T.;Sanz-Aparicio, J.;Tollin, G.;Gomez-Moreno, C.;Medina, M. Role of Arg100 and Arg264 from Anabaena PCC 7119 ferredoxin-NADP(+) reductase for optimal NADP(+) binding and electron transfer. BIOCHEMISTRY. 1998. DOI: 10.1021/bi981718i Cinkaya, I.;Buckel, W.;Medina, M.;Gomezmoreno, C.;Cammack, R. Electron-nuclear double resonance spectroscopy investigation of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: Comparison with other flavin radical enzymes. BIOLOGICAL CHEMISTRY. 1997 Martinez, J. I.;Alonso, P. J.;Gomezmoreno, C.;Medina, M. One- and two-dimensional ESEEM spectroscopy of flavoproteins. BIOCHEMISTRY. 1997 Medina, M.; Vrielin, A.; Cammack, R. Electron spin echo envelope modulation studies of the semiquinone anion radical of cholesterol oxidase from Brevibacterium sterolicum. FEBS LETTERS. 1997. DOI: 10.1016/S0014-5793(96)01372-5 Inda, L. A.;Medina, M.;Saraiva, L. M.;Gomez-Moreno, C.;Teixeira, M.;Peleato, M. L. Characterisation of cytochrome c(6) from Chlorella fusca. PHOTOSYNTHESIS RESEARCH. 1997 Medina, M.;Louro, R. O.;Gagnon, J.;Peleato, M. L.;Mendes, J.;Gomezmoreno, C.;Xavier, A. V.;Teixeira, M. Characterization of cytochrome c(6) from the cyanobacterium Anabaena PCC 7119. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 1997 Serre, L.;Vellieux, F.;Medina, M.;Gomez Moreno, C.;Fontecilla Camps, J. C.;Frey, M. Crystal structures of a ferredoxin:NADP(+) reductase and of a complex with NADP(+). BIOCHEMICAL SOCIETY TRANSACTIONS. 1996 Serebryakova, L.T.; Medina, M.; Zorin, N.A., Gogotov, I.N.; Cammack, R. Reversible hydrogenase of Anabaena variabilis ATCC 29413. Catalytic properties and characterization of redox centres. FEBS LETTERS. 1996 Dole, F.;Medina, M.;More, C.;Cammack, R.;Bertrand, P.;Guigliarelli, B. Spin-spin interactions between the Ni site and the [4Fe-4S] centers as a probe of light-induced structural changes in active Desulfovibrio gigas hydrogenase. BIOCHEMISTRY. 1996. DOI: 10.1021/bi961662x Serre, L.;Vellieux, F. M. D.;Medina, M.;Gomez-Moreno, C.;Fontecilla-Camps, J. C.;Frey, M. X-ray structure of the Ferredoxin:NADP(+) reductase from the cyanobacterium Anabaena PCC 7119 at 1.8 angstrom resolution, and crystallographic studies of NADP(+) binding at 2.25 angstrom resolution. JOURNAL OF MOLECULAR BIOLOGY. 1996. DOI: 10.1006/jmbi.1996.0553 Medina, M.; Cammack, R. Flavoproteins involved in the photosynthetic electron transport in the cyanobacterium Anabaena sp PCC 7119. Electron spin-echo envelope modulation studies. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. 1996 Medina, M.; Hatchikian, E.C.; Cammack, R. Studies of light-induced nickel signals in hydrogenases: Comparison of enzymes with and without selenium. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 1996 Zorin, N.A.; Medina, M.; Pusheva, M.A.; Gogotov, I.N.; Cammack, R. Hydrogenase from the thermophilic bacterium Thermococcus stetteri. Purification and charactrization of EPR-detectable redox centres. FEMS MICROBIOLOGY LETTERS. 1996 Medina, M.;Gomez Moreno, C.;Cammack, R. Electron-Spin-Resonance and Electron-Nuclear Double-Resonance Studies of Flavoproteins Involved in the Photosynthetic Electron-Transport in the Cyanobacterium Anabaena Sp Pcc-7119. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1995 Navarro, J. A.;Hervas, M.;Pueyo, J. J.;Medina, M.;Gomezmoreno, C.;Delarosa, M. A.;Tollin, G. Laser Flash-Induced Photoreduction of Photosynthetic Ferredoxins and Flavodoxin by 5-Deazariboflavin and by a Viologen Analog. PHOTOCHEMISTRY AND PHOTOBIOLOGY. 1994 Gomez Moreno, C;Medina, M;Hurley, J.K;Cusanovich, M.A;Markley, J.L;Cheng, H;Xia, B;Chae, Y.K;Tollin, G. Protein Engineering for the Elucidation of the Mechanism of Electron-Transfer in Redox Proteins. BIOCHEMICAL SOCIETY TRANSACTIONS. 1994 Medina, M.;Gomez Moreno, C.;Cammack, R. Esr and Endor Characterization of Flavodoxin from Anabaena Sp Pcc-7119. BIOCHEMICAL SOCIETY TRANSACTIONS. 1994 Medina, M.; Vrielin, A.; Cammack, R. ESR and electron nuclear double resonance characterization of the Cholesterol oxidase from Brevibacterium sterolicum in its semiquinone state. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1994. DOI: 10.1111/j.1432-1033.1994.tb18943.x Hurley, J. K.;Medina, M.;Gomez Moreno, C.;Tollin, G. Further Characterization by Site-Directed Mutagenesis of the Protein-Protein Interface in the Ferredoxin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1994. DOI: 10.1006/abbi.1994.1335 Medina, M.; Williams, R.; Hatchikian, E.C.; Cammack, R. Studies of light-induced nickel EPR signals in Desulfovibrio gigas hydrogenase. JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS. 1994 Medina, M.; Bazo, G.I.; Fillat, M.F.; Cómez-Moreno, M. Structure predictions of Ferredoxin-NADP+ reductase from the cyanobacterium Anabaena sp PCC 7119. PROTEIN SEQUENCES & DATA ANALYSIS. 1993 Medina, M.;Diaz, A.;Hervas, M.;Navarro, J. A.;Gomez Moreno, C.;Delarosa, M. A.;Tollin, G. A Comparative Laser-Flash Absorption-Spectroscopy Study of Anabaena Pcc-7119 Plastocyanin and Cytochrome C-6 Photooxidation by Photosystem-i Particles. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1993. DOI: 10.1111/j.1432-1033.1993.tb17863.x Hurley, J. K.;Salamon, Z.;Meyer, T. E.;Fitch, J. C.;Cusanovich, M. A.;Markley, J. L.;Cheng, H.;Xia, B.;Chae, Y. K.;Medina, M.;Gomezmoreno, C.;Tollin, G. Amino-Acid-Residues in Anabaena Ferredoxin Crucial to Interaction with Ferredoxin Nadp+ Reductase - Site-Directed Mutagenesis and Laser Flash-Photolysis. BIOCHEMISTRY. 1993 Hurley, J. K.;Cheng, H.;Xia, B.;Markley, J. L.;Medina, M.;Gomez Moreno, C.;Tollin, G. An Aromatic Amino-Acid is Required at Position-65 in Anabaena Ferredoxin for Rapid Electron-Transfer to Ferredoxin Nadp+ Reductase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1993 Medina, M.;Peleato, M. L.;Mendez, E.;Gomez Moreno, C. Identification of Specific Carboxyl Groups on Anabaena Pcc-7119 Flavodoxin which are Involved in the Interaction with Ferredoxin-Nadp+ Reductase. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1992 Medina, M.;Mendez, E.;Gomez Moreno, C. Identification of Arginyl Residues Involved in the Binding of Ferredoxin Nadp+ Reductase from Anabaena Sp Pcc-7119 to its Substrates. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1992. DOI: 10.1016/0003-9861(92)90276-3 Medina, M.;Gomez Moreno, C.;Tollin, G. Effects of Chemical Modification of Anabaena Flavodoxin and Ferredoxin Nadp+ Reductase on the Kinetics of Interprotein Electron-Transfer Reactions. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1992. DOI: 10.1111/j.1432-1033.1992.tb17457.x Medina, M.;Hervas, M.;Navarro, J. A.;Delarosa, M. A.;Gomez Moreno, C.;Tollin, G. A Laser Flash Absorption-Spectroscopy Study of Anabaena Sp Pcc-7119 Flavodoxin Photoreduction by Photosystem-i Particles from Spinach. FEBS LETTERS. 1992 Medina, M.;Mendez, E.;Gomez-Moreno, C. Lysine Residues on Ferredoxin-Nadp+ Reductase from Anabaena Sp Pcc-7119 Involved in Substrate Binding. FEBS LETTERS. 1992. DOI: 10.1016/0014-5793(92)80014-8 Serre, L.;Medina, M.;Gomez Moreno, C.;Fontecilla Camps, J. C.;Frey, M. Crystals of Anabaena Pcc-7119 Ferredoxin-Nadp+ Reductase. JOURNAL OF MOLECULAR BIOLOGY. 1991 Sancho, J.;Medina, M.;Gomez-Moreno, C. Arginyl Groups Involved in the Binding of Anabaena Ferredoxin-Nadp+ Reductase to Nadp+ and to Ferredoxin. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1990 Comunicaciones Perez-Amigot, D.;Taleb, V.;Boneta, S.;Anoz-Carbonell, E.;Sebastian, M.;Polo, V.;Martinez-Julvez, M.;Medina, M. The folded FAD conformation in the ferredoxin-NADP(+) reductase from the Brucella ovis pathogen governs the NADPH dependent reductive-half reaction. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2019 Libros editors, S. Frago, C. Gómez-Moreno, M. Medina. Flavins and flavoproteins 2008: proceedings of the Sixteenth International Symposium : Jaca, Spain, June 8-13, 2008. 2008 Capítulos Apoptosis-Inducing Factor 1, Mitochondrial. Ferreira Neila, Patricia; Villanueva Llop, Raquel; Martínez Júlvez, Marta María; Medina Trullenque, María Milagros;. ENCYCLOPEDIA OF SIGNALING MOLECULES, 2ND EDITION. 2018 Electron Transferases. P. Ferreira; M. Martínez-Júlvez; M. Medina. METHODS IN MOLECULAR BIOLOGY, FLAVINS AND FLAVOPROTEINS. 2014 Atomic Force Microscopy as a tool to understand the mechanostability of Ferredoxin-NADP+ reductase complexes with its protein partners. C. Gómez-Moreno; C. Marcuello; R. De Miguel; M. Medina; M. Martínez-Júlvez; A. Lostao. FLAVINS AND FLAVOPROTEINS 2011. 2013 FMN and FAD biosynthesis in Prokaryotes: The FADS synthetase family. A. Serrano, B. Herguedas, S. Frago, S. Arilla-Luna, P. Ferreira, A. Velázquez-Campoy, M. Martínez-Jú. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2011. 2013 Modulatin flavin reoxidation in fungal aryl-alcohol-oxidase: Involvement of Phe501 contiguous to catalytic efficiency. A. Hernández-Ortega; F. Lucas; P. Ferreira; M. Medina; V. Guallar; A.T. Martínez. FLAVINS AND FLAVOPROTEINS 2011. 2013 Ser80 in Anabaena Ferredoxin-NADP+ reductase contributes to stabilize the catalytically competent complex NADP+. A. Sánchez-Azqueta; I. Lans; J.R. Peregrina; R. Hurtado-Guerrero; M. Martínez-Júlvez; M. Medina. FLAVINS AND FLAVOPROTEINS 2011. 2013 Stereoselective hydride transfer mechanism in substrate oxidation by aryl-alcohol oxidase. A. Hernández-Ortega; P. Ferreira; P. Merino; M. Medina; V. Guallar; A.T. Martínez. FLAVINS AND FLAVOPROTEINS 2011. 2013 Unraveling the role of the reductase activity of the human apoptosis inducing factor (hAIF). P. Ferreira; R. Villanueva; A. Usón; M.D. Miramar; S. Susin; M.L. Peleato; M. Medina. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS, 2011. 2013 Enzymes of FMN and FAD metabolism. M. Medina. HANDBOOK OF FLAVOPROTEINS. 2012 Revisiting the mechanism of interaction and electron transfer between Flavodoxin and Ferredoxin NADP+-reductase by fast kinetic methods with photodiode array detection. A. Serrano; M. Medina. ADVANCES IN PHOTOSYNTHESIS. FUNDAMENTAL ASPECTS. 2012 Studying the allosteric energy cycle by isothermal titration calorimetry. M. Martínez-Júlvez; O. Abian; S. Vega; M. Medina; A. Velázquez-Campoy. METHODS IN MOLECULAR BIOLOGY. 2012 Unraveling the catalysis mechanisms of Aryl-alcohol oxidase and related GMC oxidoreductases. A. Hernández-Ortega; A.T. Martinez; P. Ferreira; M. Medina; K. Borrell; V. Guallar. OXIDATIVE ENZYMES AS SUSTAINABLE INDUSTRIAL BIOCATALYSTS. 2010 Catalytic mechanisms of aryl-alcohol oxidase from Pleurotus eryngii. Patricia Ferreira, Maria J. Martínez, Jesús Jiménez-Barbero, Ángel T. Martínez, Beatriz Herguedas. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Flavin role in protein-protein interaction and electron transfer: from photosystem I to NADPH, a case study. José R. Peregrina, Isaias Lans, Ana Sánchez-Azqueta, Susana Frago, Ángels González-Lafont, José M. L. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Interaction of FAD synthetase from Corynebacterium ammoniagenes with its substrates. Susana Frago, Ana Serrano, Sonia Arilla, Adrián Velázquez-Campoy. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Mapping hot spots on the Anabaena flavodoxin binding site for the interaction with its counterpart ferredoxin-NADP+ reductase. Guillermina Goñi, Beatriz Herguedas, José R. Peregrina, Carlos Gómez-Moreno, Juan A. Hermoso, Marta. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Protonation effects coupled to the binding of ferredoxin/flavodoxin to ferredoxin NADP+ reductase from Anabaena. Marta Martínez-Júlvez, Adrián Velázquez-Campoy. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Rhodobacter capsulatus ferredoxinVI and ferredoxin(flavodoxin)–NADP(H) oxidoreductase are redox partners in vitro. Verónica Dumit, Ana Bortolotti, Néstor Carrillo, Néstor Cortez, Yves Jouanneau. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 The coenzyme binding site of bacterial ferredoxin/flavodoxin-NADP(H) reductases. Inmaculada Pérez-Dorado, Juan A. Hermoso, Guillermina Goñi, Ana Bortolotti, Néstor Carrillo and Nést. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2008. 2008 Sequence and Phylogenetic Analysis of FAD Synthetase. Luisa Schubert, Susana Frago, Marta Martínez-Júlvez. FROM PHYSICS TO BIOLOGY. THE INTERFACE BETWEEN EXPERIMENT AND COMPUTATION. 2006 Sequence and Phylogenetic Analysis of FAD Synthetase. Schubert, L; Frago, Susana; Martínez-Júlvez, Marta; Medina, Milagros. FROM PHYSICS TO BIOLOGY. THE INTERFACE BETWEEN EXPERIMENT AND COMPUTATION. AMERICAN INSTITUTE OF PHYSICS SERIES 851. 2006 John K. Hurley ... [et al.], Milagros Medina and Carlos Gómez-Moreno. Electron transfer from Ferredoxin and Flavodoxin to Ferredoxin: NADP+ reductase. PHOTOSYSTEM I: THE LIGHT-DRIVEN PLASTOCYANIN : FERREDOXIN OXIDOREDUCTASE. 2006 Effect of substituting Cl for the 8-CH3 group of FMN on the redox properties of flavodoxin from Anabaena PCC 7119 and on the flavin-apoprotein interaction. Susana Frago, Dale E. Edmondson, Carlos Gómez-Moreno, Stephen G. Mayhew. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2005. 2005 Kinetic Studies on Aryl-alcohol oxidase from Pleurotus eryngii. Patricia Ferreira, María J. Martínez, Angel T. Martínez, and Milagros Medina. FLAVINS AND FLAVOPROTEINS 2005. 2005 Revisiting the catalytic mechanism of interaction and electron transfer between Flavodoxin and Ferredoxin NADP+-Reductase by fast kinetic methods. Carlos Gómez-Moreno; Ana Serrano; Guillermina Goñi; Susana Frago; Milagros Medina. FLAVINS AND FLAVOPROTEINS 2005. 2005 Role of Anabaena Flavodoxin Hydrophobic Residues in Protein-protein Interaction and Electron Transfer to Ferredoxin-NADP+ Reductase. Susana Frago, Guillermina Goñi, Ana Serrano, Stephen G. Mayhew, Carlos Gómez-Moreno. PHOTOSYNTHESIS: FUNDAMENTAL ASPECTS TO GLOBAL PERSPECTIVAS 2. 2005 Specificity for the coenzyme in ferredoxin-NADP+ reductase: an attempt to create a NAD+/H dependent enzyme. Marta Martínez-Júlvez, Jesús Tejero, José Ramón Peregrina, Carlos Gómez-Moreno. PHOTOSYNTHESIS: FUNDAMENTAL ASPECTS TO GLOBAL PERSPECTIVES 2. 2005 Structural model of the FAD synthetase from Corynebacterium ammoniagenes. Marta Martínez-Júlvez, José R. Peregrina, Susana Frago. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2005. 2005 Study of Anabaena PCC 7119 apoflavodoxin stability by fluorescence resonance energy. José R. Peregrina. PROCEEDINGS OF FLAVINS AND FLAVOPROTEINS 2005. 2005 Electron Transfer in the Hybrid System between Anabaena Ferredoxin-NADP+ Reductase and Bovine Adrenodoxin. Faro, M., Gómez-Moreno,C., Schiffler, B., Heinz, A. and Bernhardt, R. PROCEEDINGS OF THE FOURTEENTH INTERNATIONAL SYMPOSIUM FLAVINS AND FLAVOPROTEINS. 2002 Involvement of the Pyrophosphate and Nicotinamide Binding Regions of Anabaena PCC 7119 Ferredoxin-NADP+ Reductase in Coenzyme Specificity. J. Tejero, C. Gómez-Moreno. PROCEEDINGS OF THE FOURTEENTH INTERNATIONAL SYMPOSIUM FLAVINS AND FLAVOPROTEINS. 2002 Role of Residues Thr56, Asn58 and Asn97 from Anabaena Flavodoxin in Electron Transfer Processes with Ferredoxin-NADP+ Reductase. Nogués, I., Gómez-Moreno, C. PROCEEDINGS OF THE FOURTEENTH INTERNATIONAL SYMPOSIUM FLAVINS AND FLAVOPROTEINS. 2002 Role of the Carboxyl-terminal Tyrosine of Ferredoxin-NADP+ Reductase in the Electron Transfer Processes with the Protein Carriers Ferredoxin and Flavodoxin. I. Nogués, J. Tejero, C. Gómez-Moreno, J.K. Hurley, G. Tollin, D.V. Rial, E. Ceccarelli and N. Carri. PROCEEDINGS OF THE FOURTEENTH INTERNATIONAL SYMPOSIUM FLAVINS AND FLAVOPROTEINS,. 2002 Theoretical Analysis of the Changes Introduced in the Electron Spin Density Distribution of the Neutral Flavin Semiquinone Isoalloxazine Ring upon Modification of the Isoalloxazine Ring. S. Frago, J.I. Martínez. PROCEEDINGS OF THE FOURTEENTH INTERNATIONAL SYMPOSIUM FLAVINS AND FLAVOPROTEINS. 2002 C. Gómez-Moreno ... [et al.]. Ingeniería y diseño de proteínas para su utilización en procesos para su utilización en procesos industriales. CIENCIA Y TECNOLOGÍA DEL SIGLO XXI. 2001 Advanced EPR spectroscopic studies of mutants of Ferredoxin-NADP+ reductase from pea. Medina, M.; Gómez-Moreno, C.; Cammack, R.; Arakaki, A.K.; Carrillo,N.; Ceccarelli, E.A. FLAVINS AND FLAVOPROTEINS. 1999 Determinants of Cofactor Specificity in Anabaena PCC 7119 Ferredoxin-NADP+ reductase. Tejero, J.; Luquita, A.; Grever, K.; Perham, R.; Gómez-Moreno, C.; Medina, M. FLAVINS AND FLAVOPROTEINS. 1999 Molecular recognition between Ferredoxin-NADP+ reductase and its protein partners: Role of Charged and Hydrophobic Residues. Martínez Júlvez, Marta María. FLAVINS AND FLAVOPROTEINS 1999. 1999 Role of glutamic acid 139 in the catalytic mechanism of Ferredoxin-NADP+ reductase from Anabaena PCC 7119. Faro-Tomás, M.; Medina, M.; Hurley,J.K.; Tollin, G.; Gómez-Moreno, C. FLAVINS AND FLAVOPROTEINS. 1999 Milagros Medina y Richard Cammack. Espectroscopia de resonancia paramagnética electrónica en sistemas biológicos. ESPECTROSCOPIA DE RESONANCIA PARAMAGNÉTICA ELECTRÓNICA. 1997 Amino acid residues in Anabaena Ferredoxin crucial to interaction with Ferredoxin-NADP+ reductase: site directed mutagenesis and laser flash photolysis. Hurley, J.K.; Salamon, Z.; Meyer, T.E.; Fitch, J.; Cusanovich, M.A.; Markley, J.; Cheng, H.; Xia, B.; Medina, M.; Gómez-Moreno, C.; Tollin, G. FLAVINS AND FLAVOPROTEINS. 1994 Structural study of Ferredoxin-NADP+ reductase from Anabaena PCC 7119 and of its complex with NADP+. Serre, L.; Medina, M.; Vellieux, F.M.D.; Gómez-Moreno, C.; Fontecilla-Camps, J.; Frey, M. FLAVINS AND FLAVOPROTEINS PP. 431-434. 1994 Structural analysis of the requirements for the formation of an electron transfer complex. Blancas, C., Peleato, M. L., Gómez-Moreno, c. FLAVINS AND FLAVOPROTEINS. 1991 Colaboraciones en ediciones de revista Current pharmaceutical design. 1381-6128. 04/02/13 - 01/04/13 Proyectos PID2022-136369NB-I00: Sistemas dependientes de flavinas: funciones multitarea desde catálisis redox versátil a moléculas de señalización y detección celular. 01/09/23 - 31/08/26 E35_23R: Grupo de referencia biología estructural. 01/01/23 - 31/12/25 Enzymatic properties and interaction network of the Mycobacterium tubercolosis rhodanese-like protein SseA. 16/12/22 - 23/12/23 1 Novel antimicrobials: A platform for detection of inhibition of target enzymes. Alianza UNITA-Universitá di Torino. IP Sheila Shagedi (IP en Zaragoza M. Medina). Universitá di Torino-Universidad de Zaragoza. 01/10/2022 - 30/11/2023. 11.000 €. 01/10/22 - 31/12/23 EQUZ2022-BIO-07: Sistema de cromatografía líquida de alta velocidad y resolución (FPLC/HPLC) bioinerte y biocompatible, para purificación de proteínas y biomoléculas, a temperatura ambiente o en cámara fría. Detección UV-Vis de triple longitud de onda y conductividad. Válvulas de: inyección de muestra, entrada de tampones, salida y selección de columnas, y colector de fracciones. Todos los componentes deben poderse monitorizar a través de un software, y el equipamiento informático (PC) para su manejo debe estar incluido. 01/01/22 - 30/11/22 LMP13_21: El flavoproteoma de Brucella: una herramienta para dianas terapéuticas y diagnósticas. 18/09/21 - 30/09/23 LMP27_21: Enfermedades mitocondriales asociadas al mecanismo de importación y plegamiento oxidativo de proteínas en el espacio intermembrana de la mitocondria. Mecanismos moleculares y desarrollo de nuevas estrategias terapéuticas (EMPLOXPRO). 18/09/21 - 30/09/23 PID2019-103901GB-I00: FLAVOENZIMAS EN SALUD, ENFERMEDAD Y DESCUBRIMIENTO DE FÁRMACOS. 01/06/20 - 28/02/24 E35_20R: Biología Estructural. 01/01/20 - 31/12/22 Espectrofotómetro Multicubeta (8 cubetas) y Multizona térmica de doble haz UV-vis, con configuración de cuatro zonas de temperatura independientes de medida simultánea, adaptable a la medida tanto de rampas de temperaturas como de reacciones rápidas, y con accesorio para la medida de volúmenes de muestra pequeños (microlitros). 01/01/20 - 30/11/20 EQC2019-005847-P: Implementación de modelos celulares complejos para el descubrimiento de fármacos: Equipamiento avanzado para la producción, purificación y análisis de proteínas. 01/01/19 - 31/03/22 PARACAT / Paramagnetic Species in Catalysis Research. A Unified Approach Towards Heterogeneous, Homogeneous and Enzyme Catalysis (H2020 GA Number - 813209). 01/01/19 - 30/06/23 GRUPO DE REFERENCIA BIOLOGÍA ESTRUCTURAL. 01/01/17 - 31/12/19 BIO2016-75183-P: FLAVOENZIMAS: MECANISMOS Y DIANAS MOLECULARES, PATOLOGÍAS Y APLICACIONES BIOTECNOLÓGICAS. 30/12/16 - 31/12/20 GRUPO CONSOLIDADO B18 BIOLOGÍA ESTRUCTURAL. 01/01/16 - 31/12/16 GRUPO CONSOLIDADO B18 BIOLOGÍA ESTRUCTURAL. 01/01/15 - 31/12/15 Neuromed / Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR. 01/05/14 - 30/06/15 BIO2013-42978-P: SISTEMAS DEPENDIENTES DE FLAVOENZIMAS: DE SUS MECANISMOS DE ACCIÓN A SUS APLICACIONES BIOTECNOLÓGICAS Y SANITARIAS. 01/01/14 - 31/10/17 GRUPO CONSOLIDADO B18 BIOLOGÍA ESTRUCTURAL. 01/01/14 - 31/12/14 GRUPO CONSOLIDADO B18 BIOLOGÍA ESTRUCTURAL. 01/01/13 - 31/12/13 Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain. 28/11/11 - 28/11/15 SAF2011-15732-E. BIFI2012-PROTEIN TARGETS: DISCOVERY OF BIOACTIVE COMPOUNDS. 26/10/11 - 25/10/13 FCT-11-1909.REALIDAD AUMENTADA. 01/06/11 - 30/05/12 BIO2010-14983.MECANISMOS CATALITICOS EN FLAVOENZIMAS:CLAVE PARA SU UTILIZACION BIOTECNOLOGICA O TERAPEUTICA. 01/01/11 - 30/09/14 GRUPO CONSOLIDADO B18 BIOLOGIA ESTRUCTURAL. 01/01/11 - 31/12/12 BIO2007-29813-E 16TH INTERNATIONAL SYMPOSIUM ON FLAVINS AND FLAVOPROTEINS. 01/02/08 - 15/12/08 GRUPO EXCELENTE B18 BIOLOGIA ESTRUCTURAL. 01/01/08 - 31/12/10 BIO2007-65890-C02-01 FLAVOPROTEINAS Y FLAVOENZIMAS: TRANSFORMACIÓN DE ENERGÍA Y DIANAS FARMACOLÓGICAS. 01/10/07 - 04/10/10 PM062/2007 BIOFÍSICA DE PROTEÍNAS IMPLICADAS EN PROCESOS DE TRANSPORTE EN ORGANISMOS FOTOSINTÉTICOS. 01/10/07 - 30/09/09 PROYECTO DE COOPERACIÓN ENTRE DEPARTAMENTOS UNIVERSITARIOS Y DEPARTAMENTOS DE CENTROS DE ENSEÑANZA SECUNDARIA: LA INVESTIGACIÓN EN EL AULA. UN PROYECTO DE PARTICIPACIÓN Y DIFUSIÓN DE LA INVESTIGACIÓN CIENTIFICA EN INSTITUTOS DE SECUNDARIA. 17/09/07 - 15/06/08 BIO2007-28712-E. INTERNATIONAL NETWORK OF PROTEIN ENGINEERING CENTERS. 01/03/07 - 15/12/07 PM057/2006 ACELERACIÓN DEL CRIBADO VIRTUAL PARA EL DESARROLLO DE FÁRMACOS EN UN SUPERORDENADOR DE FPGAs. 01/10/06 - 30/09/08 PIP122/2005. APLICACION DE TECNICAS COMPUTACIONALES Y NANOBIOLOGICAS AL ESTUDIO DE LOS MECANISMOS DE REACCION DE PROTEINAS. 01/11/05 - 31/10/07 INF2005-BIO-006. ACCESORIO INTEGRADOR PARA LA ADQUISICION DE SEÑAL EN MODO PULSDO DEL ESPECTROMETRO DE EPR BRUKER ESP 380. 13/07/05 - 31/12/05 GRUPO EXCELENTE DGA B18 BIOLOGIA ESTRUCTURAL. 01/01/05 - 31/12/07 BIO2004-00279. MECANISMOS DE ACCION EN FLAVOPROTEÍNAS REDOX. VERSATILIDAD, ADAPTACION Y REDISEÑO CON FINES BIOTECNOLÓGICOS DE LAS PROPIEDADES DE LA FLAVINA EN EL ENTORNO PROTEICO. 13/12/04 - 12/12/07 BIO2003-00627. REDISEÑO DEL SISTEMA ENZIMATICO DE LA FERRODOXINA-NADP+ REDUCTASA DE ANABAENA PARA LA SINTESIS DE COMPUESTOS DE INTERES BIOLOGICO Y SU APLICACIÓN EN BIOREMEDIACIÓN. 01/12/03 - 30/11/06 NATO. REF. 978882. NITROAROMATIC EXPLOSIVES: ENZYMATIC, CYTOTOXICITY, GAMMA-RADIOLYSIS AND ELECTROCHEMICAL STUDIES. 11/04/02 - 10/04/04 P111/2001.ESTUDIO, MEDIANTE TECNICAS DE RESONANCIA PARAMAGNÉTICA ELECTRÓNICA EN ONDA CONTINUA Y EN EL DOMINIO TEMPORAL, DE CITOCROMOS CADENA DE TRANSPORTE ELECTRÓNICO FOTOSINTÉTICO. 01/01/02 - 31/12/04 BQU2001-2520.VERSATILIDAD DEL ANILLO DE ISOALOXAZINA COMO CENTRO REDOX. IMPLICACIONES EN PROCESOS DE TRANSFERENCIA DE ELECTRONES ENTRE PROTEINAS. 28/12/01 - 27/12/04 P006/2000.REDISEÑO DE SISTEMAS ENZIMATICOS DEPENDIENTES DE PIRIDIN NUCLEOTICOS PARA LA SINTESIS DE COMPUESTOS DE INTERES BIOLOGICO.APLICACION. 01/01/01 - 31/12/03 CICYT BIO2000-1259. DISEÑO DE SISTEMAS ENZIMATICOS PARA LA SINTESIS DECOMPUESTOS DE INTERES BIOLOGICO. 28/12/00 - 28/12/03 P17/98.ESTUDIO DE PROTEINAS QUE INTERVIENEN EN LOS PROCESOS REDOX MEDIANTE EPR EN EL DOMINIO TEMPORAL Y ENDOR. 01/01/99 - 01/01/01 ESTABILIDAD, ESTRUCTURA Y PLEGAMIENTO DE LA FLAVODOXINA Y SUS CONFORMACIONES NO NATIVAS. 01/10/98 - 01/10/01 UZ97-CIE-09.APLICACIONES DE TÉCNICAS AVANZADAS DE RESONANCIA PARAMAGNÉTICA ELECTRÓNICA (ESEEM Y ENDOR) AL ESTUDIO DE PROTEÍNAS QUE INTERVIENEN EN PROCESOS BIOLÓGICOS DE TRANSFERENCIA DE ELECTRONES. 11/12/97 - 11/12/99 Estabilidad y ruta de plegamiento de una prote¨ªna ¦Á/¦Â: la apoflavodoxina de Anabaena PCC 7119. 01/04/97 - 31/12/97 Desarrollo de nuevos métodos para el estudio de la relación estructura-función del citocromo c6 de Anabaena PCC 7119. 01/01/97 - 31/12/97 Caracterización mediante resonancia doble electrón-núcleo de mutantes de las flavoproteínas del transporte fotosintético de electrones en la cianobacteria Anabaena PCC 7119. 01/04/96 - 01/04/97 Ingeniería de Proteínas Redox: Diseño de nuevas Oxidasas. 01/01/95 - 01/05/97 Elucidation of the catalytic mechanism of hydrogenase enzymes by electron paramagnetic resonance spectroscopy. 01/01/93 - 31/12/94 Ingeniería de proteínas transportadoras de electrones. 01/05/91 - 01/05/94 Estudios cristalográficos y bioquímicos en proteínas de oxido-reducción. Determinación de las estructuras tridimensionales. 01/01/91 - 31/12/91 Bioingeniería de la Ferredoxina-NADP+reductasa aplicaciones clínicas e industriales. 01/05/88 - 01/05/91 Contratos Biología Estructural (Retorno UZ). 01/01/19 - 31/12/25 PUESTA EN MARCHA DEL DESARROLLO TÉCNICO FOTOCATALIZADOR. 25/09/17 - 26/12/17 BIFI. 01/11/15 - 31/10/25 FLAVOENZIMAS Y BIOTECNOLOGÍA: FLAVOTECH. 01/11/15 - 31/10/20 Dirección de tesis Flavoenzymes in Microbial Systems: Analysis of Structure-Function Relationships. Universidad de Zaragoza. Sobresaliente cum laude. 07/03/24 The human Apoptosis Inducing Factor family: from the molecular mechanism of the Apoptosis Inducing Factor and the Apoptosis Inducing Factor¿Like to their functional and pathological significance. Universidad de Zaragoza. Sobresaliente cum laude. 13/07/23 Insights into the conformational landscape and interaction networks in human Apoptosis Inducing Factor. Universidad de Zaragoza. Sobresaliente cum laude. 19/07/22 Molecular and dynamic mechanisms of prokaryotic and eukaryotic flavoenzymes: insights into their implication in human metabolism and health. Universidad de Zaragoza. Sobresaliente cum laude. 22/01/21 The action mechanism of prokaryotic FAD synthetases as a potential drug target for the treatment of bacterial infections. Universidad de Zaragoza. Sobresaliente cum laude. 12/01/18 The reductase activity of the human Apoptosis Inducing Factor: molecular bases and implications in the enzyme apoptotic function. Universidad de Zaragoza. Sobresaliente cum laude. 15/12/15 Mecanismos catalíticos en ferredoxina-NADP+ reductasas de tipo planta. Universidad de Zaragoza. Sobresaliente cum laude. 04/10/13 Enzymes involved in the metabolism of flavins in prokaryotic organisms: structure-function relationship. Universidad de Zaragoza. Sobresaliente "Cum Laude". 15/07/13 Estudio teórico de los mecanismos de transferencia de electrones en flavoproteínas implicadas en la cadena fotosintética en Anabaena. Universidad de Zaragoza. Apto cum laude. 19/07/12 Proteínas con dominios de unión a flavina: bases estructurales de la biosíntesis de cofactores flavínicos en procariotas de la interacción y transferencia de electrones entre flavoproteínas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 13/05/11 Proteínas dependientes de flavina: Biosíntesis de cofactores flavínicos y procesos de interacción y transferencia de electrones. Universidad de Zaragoza. Sobresaliente "Cum Laude". 11/03/11 Flavodoxina de Anabaena PCC7119: un compromiso entre eficiencia y versatilidad en el transporte de electrones desde el Fotosistema I a la Ferredoxina-NADP+ reductasa. Universidad de Zaragoza. Sobresaliente "Cum Laude". 10/09/10 Determinantes mecanísticos de la reactividad y especificidad de la Ferredoxina-NADP+ reductasa de Anabaena PCC 7119 con su coenzima. Universidad de Zaragoza. Sobresaliente "Cum Laude". 08/09/09 Biosíntesis de FMN y FAD en procariotas y modulación de las propiedades de óxido- reducción del FMN por el entorno proteico. Universidad de Zaragoza. Sobresaliente "Cum Laude". 04/10/07 Cambio de la especificidad de la enzima ferredoxina-nadp+reductasa de la cianobacteria anabaena pcc 7119 por su coenzima. Universidad de Zaragoza. Sobresaliente "Cum Laude". 20/09/04 Análisis estructural y funcional de las instrucciones que conducen a procesos eficientes de transferencia de electrones entre flavoproteínas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 02/04/04 Bases Moleculares del reconocimiento entre proteinas transportadoras de electrones. estudio del sistema de la ferredoxin-NADP+ reductosa fotosintética de anabaena y de sistemas mixtos cianobacteria-animal. Universidad de Zaragoza. Sobresaliente "Cum Laude". 30/05/02 Estudio de la interacción de la Ferredoxina-NADP+ reductasa de anabaena con los trasportadores de electrones ferredoxina y flavodoxina. Universidad de Zaragoza. Sobresaliente "Cum Laude". 02/10/98 Dirección de proyectos fin de carrera Análisis funcional de mutantes de la flavodoxina de anabæna pcc 7119 en las posiciones trp57 y tyr94. Universidad de Zaragoza. Sobresaliente. 15/09/01 Análisis funcional de mutantes de la flavodoxina de anabæna pcc 7119 en las posiciones Ile59 e Ile92. Universidad de Zaragoza. Sobresaliente. 01/06/99 Dirección de proyectos fin de grado Simulaciones Moleculares como herramientas para el estudio de enfermedades conformacionales y el descubrimiento de nuevos antimicrobianos. Universidad de Zaragoza. Matrícula de honor. 21/06/24 Caracterización funcional y estructural de dos flavoenzimas con potencial como dianas de antimicrobianos y estudio de la canalización de cofactores flavínicos; FAD sintasa y Piridoxina-5'-fosfato oxidasa de Mycobacterium tuberculosis. Universidad de Zaragoza. Matrícula de honor. 28/06/23 Cristalización de flavoproteinas para estudios de cristalografía de resolución temporal y EPR. Universidad de Zaragoza. Sobresaliente. 27/06/23 Descripción del flavoproteoma de Mycobacterium tuberculosis. Universidad de Zaragoza. Sobresaliente. 27/06/23 Desarrollo de una herramienta informática para automatizar la obtención, comparación y análisis evolutivo de secuencias de proteínas. Validación usando como caso de estudio tres flavoproteínas de Brucella ovis. Universidad de Zaragoza. Matrícula de honor. 17/02/23 Simulaciones moleculares en flavoenzimas. UDP-N-acetilenolpiruvilglucosamina reductasa (MurB) de Brucella ovis: analisis conformacional y acoplamiento de ligandos. Universidad de Zaragoza. Sobresaliente. 22/09/22 Análisis conformacional del Factor de inducción de apoptosis humano: análisis conformacional en su estado como complejo de transferencia de carga y del acoplamiento de la ciclofilina A a su estado oxidado. Universidad de Zaragoza. Matrícula de honor. 09/07/21 Mycobacterium tuberculosis: biosíntesis de cofactores flavínicos e identificación del flavoproteoma dependiente de FMN. Universidad de Zaragoza. Sobresaliente. 08/07/21 Análisis conformacional de la dinámica y acoplamiento de ligandos en flavoenzimas mediante simulación molecular. Universidad de Zaragoza. Matrícula de honor. 17/07/20 Simulaciones de dinámica molecular para el estudio del acoplamiento enzima-sustrato en flavoenzimas. Universidad de Zaragoza. Notable. 13/12/19 La FAD sintetasa de Brucella ovis: interacción con ligandos y actividad enzimática. Universidad de Zaragoza. Notable. 12/07/19 Simulación computacional para la predicción de acoplamiento enzima-sutrato en flavoenzimas. Universidad de Zaragoza. Sobresaliente. 13/07/18 Estudio del efecto inhibitorio de algunos compuestos químicos en la actividad reductasa de la ferredoxin NAPD+ reductasa del patógeno Leptospira interrogans. Universidad de Zaragoza. Notable. 15/12/17 Caracterización funcional de la AIFM3 (Apoptosis inducing factor mitochondrion-associated 3) mediante inactivación del gen por la técnica CRISPR-Cas 9 y la sobreexpresión de la proteína en bacterias y células eucariotas. Universidad de Zaragoza. Notable. 27/09/17 Caracterización cinética de la riboflavina quinasa humana y evaluación del efecto en su actividad de potenciales antimicrobianos. Universidad de Zaragoza. Notable. 19/07/17 Modelado molecular de las regiones flexibles del factor de inducción de apoptosis humano y de las interacciones con sus ligandos. Universidad de Zaragoza. Notable. 28/09/16 Simulación computacional para la predicción de acoplamiento enzima-inhibidor: identificación del sitio de unión de inhibidores de flavoenzimas esenciales en patógenos. Universidad de Zaragoza. Notable. 14/07/16 Simulación computacional para la predicción de acoplamiento enzima-sustrato: identificación del sitio de unión del coenzima en la FNR del patógeno Leptospira Interrogans. Universidad de Zaragoza. Matrícula de honor. 14/07/16 The effect of mechanotransduction conditioned media on mesenchimal stem cells. Universidad de Zaragoza. Matrícula de honor. 11/07/16 Mechanical stimulation of SW1353 chondrocyte-like cells with physiological and pathological levels of shear. Universidad de Zaragoza. Matrícula de honor. 08/07/16 Evaluación de un test de PCR en tiempo real para la detección de parainfluenza. Universidad de Zaragoza. Sobresaliente. 08/07/16 Análisis de la morfocinética de las primeras divisiones embrionarias y su relación con la viabilidad del embrión. Universidad de Zaragoza. Notable. 08/07/16 Inflamación y angiogénesis en nacimientos prematuros. Universidad de Zaragoza. Notable. 08/07/16 Evaluación del efecto de potenciales inhibidores de la actividad ferredoxina reductasa en Xanthomonas axonopodis pv citri, que actúa como patógeno en cultivos de cítricos. Universidad de Zaragoza. Sobresaliente. 08/07/15 Caracterización mediante cinéticas rápidas en estado pre-estacionario del mecanismo cinético de las actividades riboflavina quinasa y FMN ADENILIL TRANSFERASA de la FAD sintetasa procariota. Universidad de Zaragoza. Notable. 26/09/14 Identificación del sitio de unión de potenciales inhibidores de la FAD Sintetasa de patógenos humanos mediante métodos de Docking. Universidad de Zaragoza. Sobresaliente. 25/09/14 Residuos clave en la oligomerización de FAD sintetasa. Universidad de Zaragoza. Sobresaliente. 10/06/14 Dirección de proyectos fin de master Predicción del impacto energético de mutaciones en base a modelos estructurales de complejos entre proteínas generados mediante métodos de inteligencia artificial. Universidad de Zaragoza. Notable. 09/02/24 Desarrollo de un vector de expresión mediante ensamblaje de fragmentos de DNA. Universidad de Zaragoza. Notable. 08/02/24 Development of bioinformatics tools for messenger RNA design. Universidad de Zaragoza. Matrícula de honor. 17/02/23 Identification of disease-related targets for red wine polyphenols. Universidad de Zaragoza. Sobresaliente. 17/02/23 Channelling of FMN from Homo sapiens Riboflavin kinase to Pyridoxine 5'-phosphate oxidase. Universidad de Zaragoza. Matrícula de honor. 12/07/21 Caracterización molecular de Mutaciones en el Factor de Inducción de Apoptosis relacionadas con enfermedades neurológicas. Universidad de Zaragoza. Sobresaliente. 28/09/18 Purificación y caracterización estructural y funcional de la Ferredoxina NADP+ reductasa del patógeno Brucella Ovis. Universidad de Zaragoza. Sobresaliente. 27/09/18 Towards the molecular characterization of the human AIFM3 (apoptosis-inducing factor, mitochondrion-associated 3). Universidad de Zaragoza. Matrícula de honor. 21/09/18 Structural and functional characterization of ferredoxin-NADP+/H oxidoreductase (FPR) and FAD synthetase from Brucella ovis. Universidad de Zaragoza. Sobresaliente. 21/09/18 Mutaciones en el Factor de Inducción de Apoptosis humano relacionadas con enfermedades neurológicas (sindromes Charcot Marie-Tooth y Cowchock): caracterización bioquímica. Universidad de Zaragoza. Notable. 11/07/17 Selección y caracterización de nuevos compuestos con actividad antimicrobiana frente a streptococcus pneumonaie. Universidad de Zaragoza. Matrícula de honor. 08/07/16 Estudios de caracterización del centro redox del Factor de Inducción de Apoptosis humano (hAIF). Universidad de Zaragoza. Notable. 16/12/14 Caracterización de mutantes de la FADS de procariotas y búsqueda de inhibidores. Universidad de Zaragoza. Sobresaliente. 25/07/13 Relación estructura función en FAD Sintetasas de origen procariótico. Universidad de Zaragoza. Sobresaliente. 12/07/12 La función de oxido reducción del factor de inducción de apoptosis humano. Universidad de Zaragoza. Sobresaliente. 29/06/10 Creación de una librería de mutantes de Ferredoxina-NADP+ reductasa de Anabaena PCC 7119. Caracterización de mutantes sitio-dirigidos en la zonade unión al FAD. Universidad de Zaragoza. Sobresaliente. 09/09/08 Participaciones en congresos 21st International Flavins and Flavoproteins Symposium 2024. Participativo - Ponencia invitada/ Keynote. Unveiling Dynamics and Cooperativity in Homodimeric Flavoenzymes. Atlanta. 15/07/24 Metals in biology: their importance and tools to study them. Participativo - Ponencia invitada/ Keynote. There is Life Beyond Metals. Flavin cofactors and Flavoenzymes as versatile catalysts. Carcavellos. 26/05/24 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis and Brucella ovis: purification and functional and structural characterization. Zaragoza. 05/09/23 45º Congreso de la SEBBM (Sociedad Española de Bioquímica y Biología Molecular). Participativo - Póster. A potential alkene reductase in Brucella ovis: bioinformatics analysis, expression, purification and kinetic characterization. Zaragoza. 05/09/23 45º Congreso de la SEBBM (Sociedad Española de Bioquímica y Biología Molecular). Participativo - Póster. Nanomechanical study of enzyme:coenzyme complexes: bipartite sites in ferredoxin-NADP+ reductase for the interaction with NADP+. Zaragoza. 05/09/23 45º Congreso de la SEBBM (Sociedad Española de Bioquímica y Biología Molecular). Participativo - Póster. Insights into UDPacetylglucosamine enolpyruvate reductase (MurB) of Brucella ovis: structural and functional analysis of a key enzyme in peptidoglycan biosynthesis. Zaragoza. 05/09/23 45º Congreso de la SEBBM (Sociedad Española de Bioquímica y Biología Molecular). Participativo - Póster. Pyridoxine 5’-phosphate oxidase from Mycobacterium tuberculosis and Brucella ovis: purification and functional and structural characterization. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. UDP-N-acetylglucosamine Enolpyruvate Reductase (MurB) of Brucella ovis: Structural and Functional Analysis of a Key Enzyme in Peptidoglycan Biosynthesis. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. A potential alkene reductase in Brucella ovis: bioinformatics analysis, expression, purification and kinetic characterization. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. The role of cyclic FMN in the flavin homeostasis and its potential effect in the riboflavin kinase activity. Zaragoza. 05/09/23 45º Congreso de la SEBBM (Sociedad Española de Bioquímica y Biología Molecular). Participativo - Póster. Searching for potential drugs to inhibit the activity of the enzyme MurA involved in the cell wall biosynthesis in Brucella ovis. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Characterization of the physiological implications of AIF and CHCHD4 interaction. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Nanomechanical study of enzyme:coenzyme complexes: bipartite sites in ferredoxin-NADP+ reductase for the interaction with NADP+. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Searching for potential drugs to inhibit the activity of the enzyme MurA involved in the cell wall biosynthesis in Brucella ovis. Zaragoza. 05/09/23 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Ponencia oral (comunicación oral). Biophysical and molecular characterization of a pathological mutation in the human Apoptosis Inducing Factor (hAIF) related with neurological disorders. Zaragoza. 05/09/23 The 47th FEBS Congress. Participativo - Póster. Addressing the potential role of human RFK in the transference of FMN to client apo-flavoproteins. Tours. 08/07/23 The 22nd FEBS Young Scientists’ Forum. Participativo - Póster. Addressing the potential role of human RFK in the transference of FMN to client apo-flavoproteins. Tours. 06/07/23 XXXIX Reunión Bienal de Química 2023. Participativo - Póster. HYDRIDE TRANSFERENCE IN TWO FLAVOENZYMES FROM A QM/MM PERSPECTIVE. Zaragoza. 25/06/23 2nd MOSBRI Scientific Conference3. Participativo - Póster. Addressing the potential channeling of FMN from Homo sapiens Riboflavin kinase to pyridoxine 5’-phosphate oxidase. Zaragoza. 05/06/23 XI National Conference BIFI 2023. Participativo - Póster. Bacterial NrdI protein: bioinformatics analysis and optimization of expression and purification of the protein from Brucella ovis. Zaragoza. 26/01/23 XI National Conference BIFI 2023. Participativo - Ponencia oral (comunicación oral). Repositioning drugs to inhibit MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase UDP-N-acetylglucosamine 1- carboxyvinyltransferase), an enzyme committed to the biosynthesis of peptidoglycan in Brucella ovis. Zaragoza. 26/01/23 XI National Conference BIFI 2023. Participativo - Ponencia oral (comunicación oral). The use of QM/MM calculations to study the hydride transference on flavoenzymes. Zaragoza. 26/01/23 XI National Conference BIFI 2023. Participativo - Póster. AIF’s dimerization: deciphering its significance in AIF:CHCHD4 interaction and mitochondrial homeostasis. Zaragoza. 26/01/23 XI National Conference BIFI 2023. Participativo - Póster. Assembly of Riboflavin kinase to Pyridoxine 5’-phosphate oxidase as a preliminary step in the potential channeling of FMN. Zaragoza. 26/01/23 XI National Conference BIFI 2023. Participativo - Ponencia invitada/ Keynote. The Apoptosis Inducing Factor in cell death: past its key role in the assembly of the degradosome. Zaragoza. 26/01/23 Electron Paramagnetic Resonance in Catalysis. Participativo - Ponencia invitada/ Keynote. Flavoproteins and flavoenzymes: versatility in redox dependent electron transfer and catalysis through stabilization of transient paramagnetic intermediates. Athens. 19/09/22 44º Congreso de la SEBBM. Participativo - Póster. Site-specific phosphorylation determines NQO1 stability and activity. Málaga. 06/09/22 44º Congreso de la SEBBM. Participativo - Póster. Characterization of UDP-N-acetylglucosamine 1- carboxyvinyltransferase, an enzyme of the peptidoglycan biosynthesis pathway in Brucella ovis. Málaga. 06/09/22 44º Congreso de la SEBBM. Participativo - Póster. Characterization of UDP-N-acetylglucosamine 1- carboxyvinyltransferase, an enzyme of the peptidoglycan biosynthesis pathway in Brucella ovis. Málaga. 06/09/22 44º Congreso de la SEBBM. Participativo - Póster. Molecular insights into the formation of the DNA-degradosome complex. Málaga. 06/09/22 44º Congreso de la SEBBM. Participativo - Póster. Biochemical and Structural Characterization of MurB from the sheep pathogen Brucella ovis. Málaga. 06/09/22 VII Jornadas Doctorales Campus Iberus. Participativo - Ponencia oral (comunicación oral). MurA, an enzyme of cellular wall biosynthesis, as a potential drug target for Brucella ovis. Jaca. 27/06/22 12TH CONGRESS ON ELECTRONIC STRUCTURE: PRINCIPLES AND APPLICATIONS. Participativo - Póster. Computational approach to the hydride transfer in the human Apoptosis Inducing Factor enzyme (hAIF). Vigo. 21/06/22 8th International Iberian Biophysics Congress. Participativo - Póster. From monomer to dimer: the significance of apoptosis-inducing factor dimerization in its interaction with CHCHD4. Bilbao. 20/06/22 8th International Iberian Biophysics Congress. Participativo - Póster. Delivery of FMN from Riboflavin kinase to Pyridoxine 5’-phosphate oxidase. Bilbao. 20/06/22 8th International Iberian Biophysics Congress. Participativo - Póster. Understanding the phosphorylation effects in the antioxidant NQO1 enzyme. Bilbao. 20/06/22 Y9TH Young Scientific Workshop on Theoretical Chemistry and Computational Modelling. Participativo - Ponencia oral (comunicación oral). Computational approach to the hydride transfer in the human Apoptosis Inducing Factor enzyme (hAIF). Vigo. 20/06/22 IUBMB Advanced School, Cofactor assembly, transport and insertion. Participativo - Ponencia invitada/ Keynote. The Biosynthesis of FMN and FAD Cofactors in Prokaryotes: Species Specific Features and Target of Antimicrobials. Spetses. 16/05/22 IUBMB Advanced School, Cofactor assembly, transport and insertion. Participativo - Ponencia oral (comunicación oral). Insights into the Potential Channelling of FMN from Homo sapiens Riboflavin kinase to Pyridoxine 5’-phosphate oxidase. Spetses. 16/05/22 IUBMB Focused Meeting / FEBS Workshop on Crosstalk between Nucleus and Mitochondria in Human Disease. Participativo - Ponencia oral (comunicación oral). Tipping the Balance between Life and Death: A Portray of two Recently Discovered Pathological Mutations of the Human Apoptosis-Inducing Factor. Sevilla. 22/03/22 IUBMB Focused Meeting / FEBS Workshop on Crosstalk between Nucleus and Mitochondria in Human Disease. Participativo - Ponencia invitada/ Keynote. The Apoptosis-Inducing Factor Family in the Crosstalk between Mitochondria and Nucleus. Sevilla. 22/03/22 20th International symposium on Flavins & Flavoproteins. Participativo - Ponencia oral (comunicación oral). Mutation of a Pivotal Residue in the Apoptosis Inducing Factor leads to Critical Aftermath on NADH Oxidation. Graz. 05/09/21 20th International symposium on Flavins & Flavoproteins. Participativo - Póster. Biochemical characterization of MurB, a flavoprotein implicated in peptidoglycan biosynthesis in Brucella ovis. Graz. 05/09/21 20th International symposium on Flavins & Flavoproteins. Participativo - Póster. QM/MM simulations on the human apoptosis inducing factor flavoenzyme. Graz. 05/09/21 20th International symposium on Flavins & Flavoproteins. Participativo - Ponencia oral (comunicación oral). Flavoenzymes and FMN/FAD biosynthesis in Brucella ovis. Graz. 05/09/21 XXV Congreso Latinoamericano de Microbiología. Participativo - Póster. Caracterización bioquímica de MurA y MurB del patógeno Brucella ovis. Asunción. 25/08/21 43rd Congress of the Spanish Biochemical and Molecular Biology Society. Participativo - Póster. Unravelling the Implications of Two Pathogenic Mutations of the Apoptosis Inducing Factor in its NADH-oxidase Properties. Barcelona. 19/07/21 XIV Biotechnology Annual Conference (BAC). Participativo - Póster. Channelling of FMN from Homo sapiens Riboflavin kinase to Pyridoxine 5’-phosphate oxidase. Zaragoza. 07/07/21 7th International Iberian Biophysics Congress. Participativo - Póster. A promising antimicrobial target in the flavoproteome of Brucella ovis: MurB, a protein implicated in peptidoglycan synthesis. Coimbra. 14/06/21 7th International Iberian Biophysics Congress. Participativo - Póster. Exploring the Contribution of Highly Conserved W483 in the NADH-oxidase Activity of human Apoptosis Inducing Factor. Coimbra. 14/06/21 7th International Iberian Biophysics Congress. Participativo - Póster. A computational approach to the hydride transfer from NADH to the human Apoptosis Inducing Factor (hAIF). Coimbra. 14/06/21 7th International Iberian Biophysics Congress. Participativo - Póster. Mining the flavoproteome of Brucella ovis, the brucellosis causing agent in Ovis aries. Coimbra. 14/06/21 X National Conference BIFI 2021. Participativo - Póster. The Catalytic Cycle of Human NQO1: Hydride Transfer, Conformational Dynamics, and Functional Cooperativity. Zaragoza. 03/02/21 X National Conference BIFI 2021. Participativo - Póster. Computational insights on the hydride transference of the human Apoptosis Inducing Factor (hAIF) enzyme. Zaragoza. 03/02/21 X National Conference BIFI 2021. Participativo - Ponencia oral (comunicación oral). W483 in the Apoptosis Inducing Factor: Thermodynamic, Kinetic and Dynamic Implications for NADH Oxidation. Zaragoza. 03/02/21 X National Conference BIFI 2021. Participativo - Ponencia oral (comunicación oral). The flavoproteome of Brucella ovis in the search of antimicrobial targets: MurB, a promising candidate. Zaragoza. 03/02/21 X National Conference BIFI 2021. Participativo - Póster. Biochemical characterisation of MurA: an essential component in peptidoglycan cell wall biosynthesis. Zaragoza. 03/02/21 X National Conference BIFI 2021. Participativo - Ponencia invitada/ Keynote. Flavoenzymes as versatile catalysts: gaining basic knowledge to develop Biotech and Biomed tools. Zaragoza. 03/02/21 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Póster. Pre-steady-state Kinetic Characterization of a Novel Thioredoxin Reductase from the Ancient Cyanobacterium Gloeobacter violaceus. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Ponencia oral (comunicación oral). Fast Kinetic Studies of Relevant Peroxidases Aimed at a Freeze-Quench EPR Spectroscopy. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Ponencia invitada/ Keynote. Human Apoptosis Inducing Factor: Molecular Basis of its Cellular Activities and Neurodegenerative Disorders. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Póster. Key Findings in the Interaction of the Human Apoptosis Inducing Factor with its Pro-apoptotic Partners for Degradosome Formation. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Póster. The FAD Synthetase, an Unexploited Antimicrobial Target against Mycobacterium tuberculosis. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Póster. Conformational Analysis of Deeply Rooted Thioredoxin Reductase from Gloeobacter by Atomic Force Microscopy. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Póster. Production and Characterization of three Mur Enzymes from the Pathogen Brucella ovis Involved in the Synthesis of the Peptidoglycan Cell Wall. Zaragoza. 03/02/20 IX INTERNATIONAL CONFERENCE BIFI 2020 “NEW CHALLENGES IN MOLECULAR BIOTECHNOLOGY”. Participativo - Ponencia oral (comunicación oral). EPR and Chemical Studies About a New Species of the CYP450 Family: the CYP116B5. Zaragoza. 03/02/20 AFM BioMed Conference. Participativo - Ponencia oral (comunicación oral). NANOMECHANICAL ANALYSIS OF NADP+ WITH FERREDOXIN-NADP+ REDUCTASE VARIANTS. Munster. 02/09/19 XIth EFEPR Conference Bratislava 2019. Participativo - Póster. 13C hyperfine coupling characterization of the flavin semiquinone by EPR techniques. Bratislava. 01/09/19 Joint 12th EBSA, 10th ICBP-IUPAP Biophysics Congress. Participativo - Póster. The folded FAD conformation in the ferredoxin-NADP+ reductase from the Brucella ovis pathogen governs the NADPH dependent reductive-half reaction. Madrid. 20/07/19 Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress 2019. Participativo - Póster. The folded FAD conformation in the ferredoxin-NADP+ reductase from the Brucella ovis pathogen governs the NADPH dependent reductive-half reaction. Madrid. 20/07/19 BIFI 2019: IX National Conference. Participativo - Póster. Study of the role of the W196 residue of the Human Apoptosis Inducing Factor. Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Ponencia oral (comunicación oral). MOLECULAR APPROACH TO THE ROLE OF hAIF: CHCHD4 INTERACTION IN THE OXPHOS ASSEMBLY AND FUNCTION. Zaragoza. 30/01/19 IX Conferencia Nacional BIFI 2019. Participativo - Póster. Biochemical Characterization and Homology Modeling of the FAD Synthetase from the Brucella ovis Pathogen. Zaragoza. 30/01/19 IX Conferencia Nacional BIFI 2019. Participativo - Póster. The Brucella ovis Flavoproteome Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Póster. Molecular characterization of the NADPH-dependent reduction of Ferredoxin-NADP+ reductase from the ovine pathogen Brucella ovis. Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Ponencia oral (comunicación oral). Kinetic and thermodynamic regulation of the FMN biosynthesis in Homo sapiens. Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Póster. Towards the molecular characterization of the human AIFM3 (apoptosis-inducing factor, mitochondrion-associated 3). Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Póster. Biochemical characterization and homology modeling of the FAD synthetase from the Brucella ovis pathogen. Zaragoza. 30/01/19 BIFI 2019: IX National Conference. Participativo - Póster. The Brucella ovis Flavoproteome. Zaragoza. 30/01/19 XII Reunión del Grupo Especializado de Microbiología Molecular. Participativo - Póster. Molecular characterization of a ferredoxin-NADP+ reductase from the Brucella ovis pathogen. Zaragoza. 05/09/18 XII Reunión del Grupo Especializado de Microbiología Molecular. Participativo - Póster. Molecular characterization of a ferredoxin-NADP+ reductase from the Brucella ovis pathogen. Zaragoza. 05/09/18 XII Reunión del Grupo Especializado de Microbiología Molecular. Participativo - Póster. An unexploited antimicrobial target against Mycobacterium tuberculosis, the FAD synthetase Zaragoza. 05/09/18 Fuerzas y Túnel. 2018. Participativo - Póster. Nanomechanics of the paradigmatic redox enzyme Ferredoxin-NADP+ reductase. Jaca. 27/06/18 2018 IIBC (6th International Iberian Biophysics Congress). Participativo - Póster. Structural and biochemical characterization of a ferredoxin-NADP+ reductase from the Brucella ovis pathogen. Castellón. 20/06/18 2018 IIBC (6th International Iberian Biophysics Congress). Participativo - Póster. Conformation-fuction relationships in the human Apoptosis Inducing Factor. Castellón. 20/06/18 2018 IIBC (6th International Iberian Biophysics Congress). Participativo - Póster. Biophysical characterization of W196 mutants of the human Apoptosis Inducing Factor. Castellón. 20/06/18 2018 IIBC (6th International Iberian Biophysics Congress). Participativo - Póster. Biophysical characterization of E336K mutant of the human Apoptosis Inducing Factor. Castellón. 20/06/18 2018 IIBC (6th International Iberian Biophysics Congress). Participativo - Ponencia oral (comunicación oral). Regulation of FMN biosynthesis in Homo sapiens: Kinetics and thermodynamics of the riboflavin kinase activity Castellón. 20/06/18 ELECMI. Top level infraestructures in Electron Microscopy for the observation, characterization and handling of materials at atomic scale. Participativo - Ponencia oral (comunicación oral). Nanomechanics of the redox complexes of the paradigmatic enzyme Ferredoxin-NADP+ reductase. Zaragoza. 11/06/18 51st Annual Meeting ESR of the Spectroscopy Group of the Royal Society of Chemistry. Participativo - Ponencia oral (comunicación oral). Studying the structural changes of human Apoptosis Inducing Factor using spin labels. London. 08/04/18 51st Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry. Participativo - Ponencia invitada/ Keynote. Studying the structural changes of human Apoptosis Inducing Factor using spin labels. Londres. 08/04/18 BIFI International Conference 2018. COMPLEXITY, NETWORKS AND COLLECTIVE BEHAVIOUR. Participativo - Póster. Molecular basis of the interaction of the human Apoptosis Inducing Factor with its nuclear partners. Zaragoza. 06/02/18 BIFI International Conference 2018. COMPLEXITY, NETWORKS AND COLLECTIVE BEHAVIOUR. Participativo - Póster. New antimicrobials targeting flavin homeostasis through FAD synthetase inhibition. Zaragoza. 06/02/18 7th Congress of European Microbiologists (FEMS). Participativo - Ponencia oral (comunicación oral). SCOUTING NEW ANTIMICROBIALS: THE FAD SYNTHETASE AS A NOVEL PROMISING TARGET. Valencia. 09/07/17 FEMS 2017. 7th congress of european microbiologist. Participativo - Póster. Scouting new antimicrobials: the FAD synthetase as a novel promising target. Valencia. 09/07/17 19th International Symposium on Flavins and Flavoproteins. Participativo - Póster. The FAD synthetase from Streptococcus pneumoniae: an enzyme exhibiting activity-dependent redox requirements. Groningen. 02/07/17 19th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Human Apoptosis Inducing Factor: from its molecular mechanism to its functional and pathological significance. Groningen. 02/07/17 19th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Kinetics and thermodynamics in ligands binding as FMN production determinants in bifunctional FAD synthetases Groningen. 02/07/17 16th Congress Spanish Biophyscial Society. Participativo - Póster. Discovery of inhibitors of the ferredoxin-NADP+ reductase from the Xantomonas citri subsp. citri fhytopatoghen. Sevilla. 06/06/17 16th Congress Spanish Biophyscial Society. Participativo - Póster. Kinetics and thermodynamics in the protein-ligand interactions during activity in the bifunctional FAD synthetase from Corynebacterium ammoniagenes. Sevilla. 06/06/17 16th Congress Spanish Biophyscial Society. Participativo - Ponencia oral (comunicación oral). Molecular basis of the interaction of the human Apoptosis Inducing Factor with its nuclear partners. Sevilla. 06/06/17 VIII BIFI National Conference. Participativo - Ponencia oral (comunicación oral). A kinetic and thermodynamic view of the protein-ligand interactions during the RFK activity of the FAD synthetase from Corynebacterium ammoniagenes. Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Spectroscopic insights into the stability of Apoptosis Inducing Factor. Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Old drugs, new uses. Novel compounds targeting the prokaryotic FAD synthetases. Zaragoza. 31/01/17 VIII National Conference BIFI 2017. Participativo - Póster. Spectroscopic insights into the stability of Apoptosis Inducing Factor. Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. The bifunctional FAD synthetase of the human pathogen Streptococcus pneumoniae Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Study of the catalytic mechanism of the adenylylation of FMN in the bifunctional FAD synthetase from Corynebacterium ammoniagenes Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. 3D structure prediction and AFM morphology study of human FAD synthase (isoform 2). Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Protein Motions Promote Hydride Tunneling in the Reduction of Aryl-Alcohol Oxidase Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Ponencia invitada/ Keynote. From antiapoptosis to detOXIfication: stumblin' in!. Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Insights into apotential chloroplast NADPH dependent flavoreductase in stroma from Arabidopsis thaliana Zaragoza. 31/01/17 VIII BIFI National Conference. Participativo - Póster. Study of the interaction between human Apoptosis Inducing Factor (hAIF) and its nuclear partners. Zaragoza. 31/01/17 International Network on Protein Engineering Centers, INPEC 2016. Participativo - Ponencia oral (comunicación oral). The human Apoptosis Inducing Factor (hAIF): from its molecular mechanism to its functional and pathological significance. Taipei 06/11/16 CM1103 Action Final Meeting. Structure-based drug design for diagnosis and treatment of neurological diseases Participativo - Ponencia invitada/ Keynote. Molecular determinants of the apoptosis inducing factor in cellular respiration, programed cell death and neurodegenerative disorders. Estambul. 21/10/16 XXIII Congreso Latinoamericano de Microbiología. Participativo - Póster. Identificación y evaluación de potenciales inhibidores de flavoproteínas de Xanthomonas citri subsp.citri. Rosario. 26/09/16 LIGNOBIOTECH IV. Participativo - Póster. Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase. Madrid. 19/06/16 5th Intenational Iberian Biophysics Conference. Participativo - Póster. In bacterial FAD Synthetases little structural variations produce big catalytic differences. Porto. 15/06/16 5th International Iberian Biophysics Congress. Participativo - Ponencia invitada/ Keynote. The human Apoptosis Inducing Factor: key molecular determinants in cellular respiration, programed cell death and neurodegenerative disorders. Porto. 15/06/16 The 56th Sanibel Symposium Participativo - Póster. The catalytic mechanism of the riboflavin kinase activity of a bifunctional FAD synthetase: An In silico study. St. Simons Island 14/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. High Throughput Screening for modulators of Apoptosis. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. Studying the structural changes of human Apoptosis Inducing Factor using site-selective spin-labeling. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from C. ammoniagenes. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. Structure-based classification of FAD binding sites: a comparative study of structural alignment tools. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. Comparing two bacterial FAD synthetases: little variations yet big differences. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. Screening and identification of compounds with antimicrobial ativity against Streptococcus pneumoniae. Zaragoza. 01/02/16 VII International Conference BIFI 2016 on Molecular Recognition. Participativo - Póster. Characterization of the interaction between human apoptosis inducing factor (hAIF) and DNA. Zaragoza. 01/02/16 XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular of the Spanish Biophysical Society. Participativo - Ponencia oral (comunicación oral). The Bacterial FAD Synthetase: a revision of its riboflavin kinase catalytic cycle. Valencia. 09/09/15 XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular of the Spanish Biophysical Society. Participativo - Póster. Role of W483 in the oxido-reductase activity of the Apoptosis Inducing Factor. Valencia. 09/09/15 XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular of the Spanish Biophysical Society. Participativo - Póster. Structural and biochemical basis of the specificity for reduced flavins of the bifunctional FAD synthetase from the human pathogen Streptococcus pneumoniae Valencia. 09/09/15 Mediterranean Neuroscience Society 2015. Participativo - Ponencia oral (comunicación oral). Drug search for Apoptosis Inducing Factor modulation in cancer and neurodegenerative disorders. Cagliary. 12/06/15 15th Congress of the Spanish Biophysical Society. Participativo - Ponencia oral (comunicación oral). Revisiting the riboflavin kinase activity of bacterial FAD Synthetase. Granada. 09/06/15 BIFI 2015: VII National Conference. Participativo - Póster. Key residues regulating the reductase activity of the human mitochondrial Apoptosis Inducing Factor. Zaragoza. 09/02/15 BIFI 2015: VII National Conference. Participativo - Póster. Structural study on stabilization of the complex formed by human Apoptosis Inducing Factor (hAIF) and its coenzyme NAD+. Zaragoza. 09/02/15 BIFI 2015: VII National Conference. Participativo - Ponencia oral (comunicación oral). Revisiting the riboflavin kinase catalytic cycle of bacterial FAD Synthetase. Zaragoza. 09/02/15 BIFI 2015: VII National Conference. Participativo - Ponencia oral (comunicación oral). Application of finite-temperature string methods to the study of hydride transfer between Anabaena FNR and NADP+/H. Zaragoza. 09/02/15 BIFI 2015: VII National Conference. Participativo - Ponencia oral (comunicación oral). Molecular Interaction model between the human Apoptosis-inducing Factor (hAIF) and the nuclease Cyclophilin A (CypA). Zaragoza. 09/02/15 19th ETSF Workshop on Electronic Excitations. Participativo - Ponencia invitada/ Keynote. Flavoproteins and Flavoenzymes: use of spectroscopy in the elucidation of action mechanisms. Zaragoza. 23/09/14 XXXVII Congreso de la SEBBM. Participativo - Ponencia invitada/ Keynote. Predicted structure and function of divergent members of prokaryotic flavin adenine dinucleotide synthetase (FADS) proteins. Granada. 09/09/14 IXth EF-EPR conference. Participativo - Póster. Tunnelling reorientation of a methyl group of the flavin ring characterized by pulse ENDOR. Marsella. 07/09/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Conformational flexibility and quaternary organization as modulators of prokaryotic FAD synthetase catalytic activities. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia invitada/ Keynote. Fungal aryl-alcohol oxidase: Genomic distribution, global reaction mechanism and industrial interest of a GMC oxidoreductase involved in natural decay of wood. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Hydride transfer reaction in alcohol oxidation by aryl-alcohol oxidase from Pleurotus eryngii: evidence for tunneling. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Organizativo - Comité científico y organizador. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Tunnelling reorientation of the C8 methyl group in the flavin ring of Anabaena flavodoxin characterized by Electron-Nuclear Double Resonance (ENDOR). Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Structural insights into the role of the coenzyme mediated monomer-dimer transition of the Apoptosis Inducing Factor. Phetchaburi. 27/07/14 18th International Symposium on Flavins and Flavoproteins. Participativo - Póster. The interaction of Leishmania major dihydroorotate dehydrogenase with the products of the catalytic reaction. Phetchaburi. 27/07/14 CM1103 Action WG3-WG4. Evaluation of New Molecules for treatment of Neurological Diseases. Participativo - Ponencia invitada/ Keynote. The apoptosis induction factor: Structural insights into its implication in neurological disorders. Siena. 30/05/14 Red Nacional de Proteínas 2014. Participativo - Ponencia oral (comunicación oral). Structural insights into the role of the coenzyme mediated monomer-dimer transition of the pro-apoptotic Apoptosis Inducing Factor. Madrid. 02/04/14 BIFI 2014: Exploring the Role of Computation in Science: From Biology to Physics. Participativo - Póster. Theoretical models in the study of the catalytic mechanism of the riboflavin kinase activity of a bifunctional FAD synthetase. Zaragoza. 23/01/14 VI International BIFI Conference 2014. Participativo - Ponencia oral (comunicación oral). Structural basis for the interaction of the FAD synthetase from the human pathogen Streptococcus pneumoniae with its ligands Zaragoza. 22/01/14 VI International BIFI Conference 2014. Participativo - Póster. Predicted structure and function of FADS-type II protein from Listeria monocytogenes. Zaragoza. 22/01/14 VI International BIFI Conference 2014. Participativo - Póster. QM/MM methods in the analysis of the mechanisms of hydride transfer processes between flavoreductases and pyridine nucleotides. Zaragoza. 22/01/14 VI International BIFI Conference 2014. Participativo - Póster. Binding of the second molecule of coenzyme to the Apoptosis Inducing Factor: Docking analysis and sequence identification of disordered regions. Zaragoza. 22/01/14 VI International BIFI Conference 2014. Participativo - Póster. Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase. Zaragoza. 22/01/14 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Prokaryotic FAD synthetase: identification of putative. Madrid. 04/09/13 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Ligand induced allosterism in the kinase module of the bifunctional FAD synthetase. Madrid. 04/09/13 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. The oxido-reductase activity of the human Apoptosis inducing factor: dimerization and catalytic efficiency. Madrid. 04/09/13 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Transient-state studies of hydrogen tunneling in aryl-alcohol oxidase from Pleurotus eryngii and its Y92W variant. Madrid. 04/09/13 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Mecanismo catalítico de la enzima Dihidroorotato deshidrogenasa de Leismania mayor. Madrid. 04/09/13 XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Comunicación intermolecular entre la L-galactono-1,4-lactona deshidrogenasa y el citocromo c de plantas. Madrid. 04/09/13 9th European Biophysics Congress EBSA2013. Participativo - Póster. Electron transfer mechanisms in the interaction between GALDH and cytochrome c. Lisboa. 13/07/13 XIII International Congress of the Spanish Biophysical Society. Participativo - Póster. Characterization of FAD synthetase mutants of Corynebacterium ammoniagenes. Valencia. 21/06/13 XIII International Congress of the Spanish Biophysical Society. Participativo - Ponencia oral (comunicación oral). Active Site Architecture and Protein Motion Evolution in Plant-Type Ferredoxin-NADP+ reductases. Valencia. 21/06/13 XIII International Congress of the Spanish Biophysical Society. Participativo - Póster. Modulation of the reductase activity of the human Apoptosis Inducing Factor by its redox induced dimerization. Valencia. 21/06/13 V Reunión de la Red Temática Nacional: Estructura y Función de Proteínas. Participativo - Ponencia invitada/ Keynote. FAD synthetase from Corynebacterium ammoniagenes: a bifunctional enzyme involved in flavin metabolism. Valencia. 17/04/13 BIFI 2013: VI National Conference. Participativo - Póster. Characterization of the putative residues involved in the adenylyltransferase activity in FAD synthetase from Conybacterium ammoniagenes. Zaragoza. 30/01/13 BIFI 2013: VI National Conference. Participativo - Póster. A hydrogen bond network in the active site of Anabaena ferredoxin-NADP+reductase modulates its catalytic efficiency. Zaragoza. 30/01/13 BIFI 2013: VI National Conference. Participativo - Póster. Analytical methods for the detection of the in vitro and in vivo quaternary organization of Conybacterium ammoniagenes FAD synthetase. Zaragoza. 30/01/13 BIFI 2013: VI National Conference. Participativo - Ponencia oral (comunicación oral). Dimerization affects the reductase and pro-apoptotic functions of the human apoptosis-inducing factor. Zaragoza. 30/01/13 BIFI 2013: VI National Conference. Participativo - Póster. Crystallographic structure of reduced human apoptosis inducing factor (hAIF) in complex with NAD+ reveals two binding sites for the coenzyme. Zaragoza. 30/01/13 5ª Jornada de Jóvenes Investigadores de Química y Física en Aragón. Participativo - Ponencia oral (comunicación oral). Análisis de los parámetros nanomecánicos de complejos proteicos mediante Microscopía de Fuerzas Atómicas. Zaragoza. 04/12/12 CM1103 Action WG Meeting. Participativo - Ponencia invitada/ Keynote. High throughput screening of inhibitors against enzymatic activities: The bacterial FAD synthetase a case study. Madrid. 24/11/12 Oxizymes. Participativo - Ponencia invitada/ Keynote. On the aryl-alcohol oxidase catalytic mechanism. Marsella. 16/09/12 22nd IUBMN and 37th FEBS Sevilla 2012. Participativo - Póster. Crystal structure of FAD-containing ferredoxin-NADP+ reductase from Xanthomonas axonopodis pv. Citri. Sevilla. 04/09/12 22nd IUBMN and 37th FEBS Sevilla 2012. Participativo - Póster. Nanomechanics of ferredoxin-NADP+ reductase complexes analyzed by AFM single-molecule force spectroscopy. Sevilla. 04/09/12 22nd IUBMN and 37th FEBS Sevilla 2012. Participativo - Póster. Atomic force microscopy reveals a dimer of trimers organization in corynebacterium ammoniagenes FAD synthetase. Sevilla. 04/09/12 22nd IUBMN and 37th FEBS Sevilla 2012. Organizativo - Comité científico y organizador. Nanomechanics of Ferredoxin-NADP+ Reductase Complexes analyzed by AFM Single-Molecule Force Spectroscopy. Sevilla. 04/09/12 12thYoung Scientists Program/iubmb&faebs 2012/FEBS. Participativo - Ponencia oral (comunicación oral). Dynamic Force Spectroscopy to Analyze Protein-Ligand Interactions: the case of Ferredoxin-NADP+ Reductase Complexes. Cádiz. 01/09/12 Young Scientific Forum IUBMB and FEBS. Participativo - Póster. Nanomechanics of ferredoxin-NADP+ reductase complexes analyzed by AFM single-molecule force spectroscopy. Cádiz. 01/09/12 International Congress of the Biophysical Society – SBE Barcelona 2012. Participativo - Ponencia invitada/ Keynote. The FMN and FAD biosynthesis in Prokaryotes: a potential drug target. Barcelona. 03/07/12 X Girona Seminar on theoretical and computational chemistry for the modeling of Biochemical systems: from Theory to Applications. Participativo - Ponencia oral (comunicación oral). Theoretical study of the mechanism of the hydride transfer between ferredoxin-NADP+ reductase and NADP+. The role of Tyr303. Girona. 02/07/12 V International Conference BIFI 2012. Protein Targets: Discovery of Bioactive Compounds. Participativo - Ponencia oral (comunicación oral). Apoptosis Inducing Factor: a promising drug target. Zaragoza. 01/02/12 V International Conference BIFI 2012. Protein Targets: Discovery of Bioactive Compounds. Participativo - Póster. Single molecule force spectroscopy as a tool to analyze protein-ligand interactions: the case of Ferredoxin-NADP+ reductase complexes. Zaragoza. 01/02/12 V International Conference BIFI 2012. Protein Targets: Discovery of Bioactive Compounds. Participativo - Póster. Atomic Force Microscopy unravels the formation of Corynebacterium ammoniagenes FAD synthetase dimer of trimers. Zaragoza. 01/02/12 V International Conference BIFI 2012. Protein Targets: Discovery of Bioactive Compounds. Participativo - Póster. Understanding the behaviour of a potential drug target: the prokaryotic FADS synthetase. Zaragoza. 01/02/12 XXXIV Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Estudio funcional de residuos implicados en las actividades riboflavina kinasa y adenililtransferasa de la FAD sintetasa de Corynebacterium ammoniagenes. Barcelona. 05/09/11 XIV Reunión de la Red Temática Biotecnología de materiales lignocelulósicos. Participativo - Ponencia oral (comunicación oral). Desentrañando el mecanismo catalítico de la enzima AAO implicada en la biodegradación de la lignina. Madrid. 05/09/11 XXXIV Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Papel de los residuos Ser59 y Ser80 en la estabilización del complejo catalíticamente competente proteína-coenzima en la ferredoxina-NADP+ reductasa de Anabaena PCC7119. Barcelona. 05/09/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Stereoselective hydride transfer mechanism in substrate oxidation by aryl-alcohol oxidase. Berkeley. 25/07/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia invitada/ Keynote. FMN and FAD biosynthesis in Prokaryotes: The FADS synthetase family. Berkeley. 25/07/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Ser80 and Ser59 in Anabaena Ferredoxin-NADP+ reductase contribute to the stabilization of the catalytically competent complex with the coenzyme. Berkeley. 25/07/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Atomic Force Microscopy as a tool to understand the mechanostability of Ferredoxin-NADP+ reductase complexes with its protein partners. Berkeley. 25/07/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Modulating flavin reoxidation in fungal aryl-alcohol oxidase: involvement of Phe501 contiguous to catalytic histidine. Berkeley. 25/07/11 17th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Unraveling the redox role of the human apoptosis inducing factor (hAIF). Berkeley. 25/07/11 BIT’s 2nd Symposium on Enzymes and Biocatalysis. Participativo - Ponencia invitada/ Keynote. Structural factors involved in the coordination of the two catalytic activities of prokaryotic FAD synthetase. Dalian. 25/04/11 V National Conference BIFI 2011. Participativo - Ponencia oral (comunicación oral). Structure of the C-terminal riboflavin kinase module of the bifunctional enzyme FADS from Corynebacterium ammoniagenes (CaFADS). Zaragoza. 02/02/11 V National Conference BIFI 2011. Participativo - Ponencia oral (comunicación oral). The riboflavin kinase and adenilyltransferase catalytic sites of the bifunctional FAD synthetase from Corinebacterium ammoniagenes. Zaragoza. 02/02/11 V National Conference BIFI 2011. Participativo - Ponencia oral (comunicación oral). Evolutionary divergence of chloroplast FAD synthetase proteins. Zaragoza. 02/02/11 V National Conference BIFI 2011. Participativo - Ponencia oral (comunicación oral). Application of Ensemble-Average Transition State Theory with Multidimensional Tunneling to the Study of Hydride Transfer between Anabaena Tyr303Ser FNR and NADP+/H. Zaragoza. 02/02/11 V National Conference BIFI 2011. Participativo - Ponencia oral (comunicación oral). Unravelling the mitochondrial role of the human apoptosis inducing factor (hAIF). Zaragoza. 02/02/11 3rd Latin American Protein Society Meeting. Participativo - Póster. Crucial residues for FAD binding and efficient hydride transfer in Anabaena ferredoxin-NADP+ reductase. Salta. 13/10/10 OzBIO 2010. The Molecules of Life: From Discovery to Biotechnology. Participativo - Póster. The three-dimensional structure of the bifunctional FAD synthetase from Corynebacterium ammoniagenes reveals oligomeric assemblies. Melbourne. 26/09/10 OzBIO 2010. The Molecules of Life: From Discovery to Biotechnology. Participativo - Póster. The catalytically-competent coenzyme allocation into the active site of Anabaena ferredoxin NADP+-reductase. Melbourne. 26/09/10 Workshop on Oxidative Enzymes as Sustainable Industrial Biocatalysts. Participativo - Póster. Unraveling the catalysis mechanisms of aryl-alcohol oxidase and related GMC oxidoreductases. Santiago de Compostela. 10/09/10 The XVth International Workshop on Quantum Atomic and Molecular Tunneling in Solids and other Condensed Phases (QAMTS 2010). Participativo - Ponencia invitada/ Keynote. Mechanism of the Hydride Transfer between Anabaena Tyr303Ser FNRrd/FNRox and NADP+/H. A Combined Pre-Steady-State Kinetic/Ensemble-Averaged Transition State Theory with Multidimensional Tunneling Study. Darmstadt. 05/09/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Structural basis of the FMN midpoint reduction potential modulation in Anabaena Flavodoxin. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Structural rearrangements in the kinase module of FAD synthetase during catalysis. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Notable residues for the correct location of flavins in the N-terminal domain of FAD syntethase from C. ammoniagenes. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Modulation of the FMN electronic properties by the protein enviroment of Anabaena Flavodoxin. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Involvement of ferredoxin-NADP+ reductase FAD and NADP+/H binding domains for optimal catalytic complex formation and hydride transfer efficiency. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Póster. Characterization of the putative residues involved in the synthesis of FMN and FAD in FAD synthetase from Corynebacterium ammoniagenes. Zaragoza. 07/07/10 IV Spanish-Portuguese biophysical congress. Participativo - Ponencia oral (comunicación oral). Human apoptosis inducing factor (hAIF):kinetic characterization of its mitochondrial reaction with NADH. Zaragoza. 07/07/10 FEBS Workshop Understanding Transient Molecular Interactions in Biology. Participativo - Póster. Role of the FAD and NADP+/H binding regions of ferredoxin-NADP+ reductase in the catalytic efficiency of the hydride transfer process. Sevilla. 18/05/10 FEBS Workshop Understanding Transient Molecular Interactions in Biology. Participativo - Ponencia invitada/ Keynote. Structural factors involved in the transient catalytically-competent coenzyme allocation in the active site of Anabaena Ferredoxin NADP+-reductase. Sevilla. 18/05/10 FEBS Workshop Understanding Transient Molecular Interactions in Biology. Participativo - Póster. The adenylylation site of C. Ammoniagenes FAD synthetase. Sevilla. 18/05/10 Workshop on Understanding Transient Molecular Interactions in Biology. Organizativo - Comité científico y organizador. Oxidation mechanism in GMC oxidoreductases:a mutagenesis, kinetics, isotopic and computacional study of fungal aryl-alcohol oxidase. Sevilla. 10/05/10 Workshop on Understanding Transient Molecular Interactions in Biology. Participativo - Póster. A preliminary study of the redox reaction of human Apoptosis-inducing factor (hAIF). Sevilla. 10/05/10 BIT’s Inaugural Symposium on Enzymes and Biocatalysis. Participativo - Póster. Structural factors involved in coenzyme specificity and transient catalytically-competent allocation in the active site of Anabaena Ferredoxin NADP+-reductase. Shangai. 21/04/10 1st Symposium on Biotechnology Applied to Lignocelluloses. Participativo - Póster. Aldehyde oxidation by Pleurotus aryl-alcohol oxidase involved in lignin biodegradation. Reims. 28/03/10 Networks: A framework for cross disciplinary applications. BIFI 2010 IV International Congress. Participativo - Otros. Zaragoza. 17/02/10 XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Localización del sitio de unión para flavinas en el dominio N-terminal de la FAD sintetasa de C. ammoniagenes. Oviedo. 23/09/09 XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudios preliminares en la caracterización redox del Factor de Inducción de Apoptosis humano (hAIF). Oviedo. 23/09/09 XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Bases estructurales de la biosíntesis de FMN y FAD en procariotas: Estructura de la FAD sintetasa de Corynebacterium ammoniagenes. Oviedo. 23/09/09 XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Implicación de la zona de unión a FAD de la enzima ferredoxina-NADP+ reductasa de Anabaena en la eficiencia catalítica y especificidad por el coenzima. Oviedo. 23/09/09 XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Bases estructurales de la biosíntesis de FMN y FAD en procariotas: Estructura de la FAD sintetasa de Corynebacterium ammoniagenes. Oviedo. 23/09/09 Biomolecles for Quality of Life. 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology. Participativo - Póster. Characterization of FAD synthetase from C. ammoniagenes. Shangai. 02/08/09 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology. Young Scientific Programm. Participativo - Póster. Characterization of FAD synthetase from C. ammoniagenes. Shangai. 02/08/09 Theoretical chemistry: modeling reactivity from gas phase to biomolecules and solids celebrating 25 years of the theoretical chemistry network of catalonia, (Spain). Participativo - Ponencia oral (comunicación oral). The mechanism of the hydride transfer between Anabaena Tyr303Ser FNRrd/FNRox and NADP+/H. A combined pre-steady-state kinetic/ensemble-averaged transition state theory with multidimensional tunneling study. Barcelona. 29/06/09 Theoretical chemistry: modeling reactivity from gas phase to biomolecules and solids celebrating 25 years of the theoretical chemistry network of catalonia, (Spain). Participativo - Póster. The Hydride Transfer Mechanism between Anabaena Tyr303Ser FNRrd/FNRox and NADP+/H. Barcelona. 29/06/09 XII Reunión de la Temática. Biotecnología de materiales lignocelulósicos: retos moleculares, enzimáticos y químicos para su aplicación industrial y medio ambiental. Participativo - Ponencia oral (comunicación oral). Profundizando en el mecanismo de acción de la enzima aril-alcohol oxidasa: una flavoproteina fúngica implicada en procesos de biodegradación de lignina. Alcalá de Henares. 04/06/09 IV National Conference Bifi2009. Participativo - Ponencia oral (comunicación oral). X-Ray Crystal Structure of C. ammoniagenes FADS: mechanistic implications. Zaragoza. 05/02/09 IV National Conference Bifi2009. Participativo - Ponencia oral (comunicación oral). Probing the catalytic mechanism of aryl-alcohol oxidase: A fungal flavoenzyme involved in lignin degradation. Zaragoza. 05/02/09 BIOTEC2008. Participativo - Ponencia invitada/ Keynote. Nuevas enzimas para el aprovechamiento de la biomasa vegetal: oxidoreductasas a la carta. Granada. 17/09/08 1st Portuguese-Spanish-Brithish Joint Biopysics Congress. Participativo - Ponencia oral (comunicación oral). Anabaena Flavodoxin, a protein designed to interact with two different protein partners, Ferredoxin-NADP+ reductase and Photosystem I. Lisboa. 10/07/08 1st Portuguese-Spanish-Brithish Joint Biopysics Congress. Participativo - Póster. Hydride transfer mechanism in Ferredoxin-NADP+ reductase. Lisboa. 10/07/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. QM/MM molecular dynamics study of the reaction between ferredoxin-NADP+ reductase (FNR) and pyridine nucleotide. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Crystallographic studies of Anabaena flavodoxin mutants. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Tracking down polar hot spots on Anabaena flavodoxin for binding and electron transfer with its physiological partners, FNR and PSI. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. The Anabaena FNR system: two binding partners, two binding modes and one energetics. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Implication of charge transfer complexes in Anabaena ferredoxin-NADP+ reductase catalysis. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. 7- and 8-methyl groups in FMN: Role in the interaction and electron transfer between Anabaena Flavodoxin and its partners, Potosystem I and Ferredoxin-NADP+ reductase. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Characterization of FAD synthetase from C. ammoniagenes by Isothermal Titration Calorimetry. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia invitada/ Keynote. Flavin role in protein-protein interction and electron transfer: from photosystem I to NADPH, a case study. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Ponencia invitada/ Keynote. Catalytic mechanisms of aryl-alcohol oxidase from Pleurotus eryngii. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Recombinant FAD synthetase from Mycobacterium tuberculosis: structural studies, cloning and purification. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. The coenzyme binding site of bacterial ferredoxin/flavodoxin NADP(H) reductases. Jaca. 08/06/08 16th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Rhodobacter capsulatus FerredoxinVI and Ferredoxin(Flavodoxin)-NADP(H) oxidoreductase are redox partners in vitro. Jaca. 08/06/08 VIII Jornadas de Bioinformática. Participativo - Póster. A computational sutudy of the hydride transfer from ferredoxin-NADP+ reductase to pyridine nucleotides. Valencia. 13/02/08 III International Conference Bifi 2008. Participativo - Póster. Studies of the catalytic mechanism of the fungal glaboenzyme Aryl-Alcohol Oxidase. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Insights into the kinetic mechanism and intermediate species in the reaction between ferredoxin-NADP+ reductase and flavodoxin. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Role of charge transfer complexes in Anabaena ferredoxin-NADP+ reductase mechanism. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Thermodynamics of FNR interaction with its substrates. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Cloning and purification of FAD synthetase from Mycobacterium tuberculosis. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Computational study of interactions among Anabaena Flavodoxin (Fld) and its cofactor FMN in their three different redox states and contribution of the different positions of the flavin ring of FMN to set the flavin properties within the Fld environment. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Characterization of a bifunctional enzyme involved in flavin metabolism: FAD synthetase from Corynebacterium ammoniagenes. Zaragoza. 06/02/08 BIFI 2008. III International Conference. Participativo - Póster. Studies of the catalytic mechanism of the fungal flavoenzyme Aryl-Alcohol Oxidase. Zaragoza. 06/02/08 International Network of Protein Engineering Centers (INPEC 2007 meeting). Participativo - Ponencia invitada/ Keynote. Structure-function studies on aryl-alcohol oxidase, a fangal flavoenzyme envolved in lignin biodegradation. Zaragoza. 13/07/07 International Network of Protein Engineering Centers (INPEC 2007 meeting). Participativo - Póster. Fast kinetics studies on the catalytic mechanism of Aryl-alcohol Oxidase, a fangal flavoenzyme envolved in lignin degradation. Zaragoza. 13/07/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. Relevant electrostatic aspects of Flavodoxin for the interaction with the reductase and the Photosystem I in the Anabaena photosynthetic chain. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Ponencia invitada/ Keynote. Enzyme-Coenzyme Interactions: Determinants for Coenzyme specificity and Hydride Exchange in NADP+/H and Flavin Dependent Systems. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Ponencia invitada/ Keynote. Characterization of Ferredoxin:NADP+ reductase interaction with NADP+, Ferredoxin and Flavodoxin by Isothermal Titration Calorimetry. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. FAD synthetase from Corynebacterium ammoniagenes, a bifunctional enzyme involved in flavin metabolism. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. Relevance of Charge Transfer Complexes in Anabaena Ferredoxin-NADP+ Reductase for Hydride Transfer. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. Contribution of the FMN electronic distribution to the conformation of the isoalloxazine environment in Anabaena Flavodoxin: a simulation analysis. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. Fast kinetics studies on the catalytic mechanism of Aryl-Alcohol Oxidase, a fungal flavoenzyme involved in lignin degradation. Jaca. 12/06/07 International Network on Protein Engineering Centers, INPEC 2007. Participativo - Póster. Electron transfer mechanism between Ferredoxin-NADP+ Reductase and Flavodoxin. Jaca. 12/06/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Póster. Computational study of Anabaena flavodoxin by point changes in the flavin ring of the FMN cofactor. Sevilla. 15/05/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Póster. Transient Interactions of Aryl-Alcohol Oxidase, a Fungal Flavoenzyme involved in Lignin Degradation, with its substrates. Sevilla. 15/05/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Póster. Predicted Cu(I) transient interaction with the N-terminal domain of the P1B-type ATPase GmHMA8 transporter in the chloroplast. Sevilla. 15/05/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Póster. Role of Electrostatic Interactions in Complex Formation and Electron Transfer from Photosystem I to Ferredoxin-NADP+ reductase via Flavodoxin. Sevilla. 15/05/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Ponencia oral (comunicación oral). Ab initio docking of transient complexes: Interaction of ferredoxin-NADP+ reductase with ferredoxin and flavodoxin. Sevilla. 15/05/07 Trends in Transient Interactions Between Biological Macromolecules. Participativo - Ponencia invitada/ Keynote. Transient Enzyme-Coenzyme Interactions for Hydride Exchange in NADP+/H and Flavin Dependent Systems. Sevilla. 15/05/07 III Reunión Nacional Bifi2007. Participativo - Póster. Medidas de cinética rápida en el sistema Ferredoxina-NADP+ reductasa y flavodoxina: efecto isotópico. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. Simulación por dinámica molecular y docking de modelos homólogos de la FAD Sintetasa de Corynebacterium ammoniagenes. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. Interacciones de la enzima FNR con sus ligandos NADP+ y Fd/Fld. Caracterización termodinámica mediante calorimetría de titulación isoterma. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. Dinámica molecular en la FNR de Anabaena PCC7119 y análisis del papel catalítico del residuo C-terminal. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. FAD Sintetasa de C. ammoniagenes, el complejo mecanismo de una enzima bifuncional. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Ponencia oral (comunicación oral). Predicción de la estructura tridimensional del dominio de unión a metal del transportador Cu-P1BATPasa cloroplástico GMHMA8. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. Estudios mediante cinéticas rápidas con flujo de teñido de la aril alcohol oxidasa: una flavoenzima fúngica involucrada en la degradación de lignina. Zaragoza. 01/03/07 III Reunión Nacional Bifi2007. Participativo - Póster. Estudio del mecanismo de reconocimiento y transferencia de electrones entre la flavodoxina de Anabaena PCC7119 con sus sustratos naturales: la ferrodoxina-NADP+ reductasa (FNR) y el fotosistema I (PSI). Zaragoza. 01/03/07 7th Spanish Symposium on Bioinformatics and Computational Biology. Participativo - Póster. Molecular dynamics study of homologous models of FAD synthetase from Corynebacterium ammoniagenes: estimation of flexible regions putatively involved in substrates interactions. Zaragoza. 20/11/06 7th Spanish Symposium on Bioinformatics and Computational Biology. Participativo - Póster. Molecular dynamics of Anabaena PCC 7119 FNR: analysis of the catalytic role of the enzyme C.terminal residue. Zaragoza. 20/11/06 42th Annual Meeting Argentine Society for Biochemistry and Molecular Biology Research. Participativo - Póster. Insights into de design of a hybrid electron transfer system composed by proteins from Anabaena. Rosario. 15/11/06 42th Annual Meeting Argentine Society for Biochemistry and Molecular Biology Research. Participativo - Póster. Spectroscopic analysis of the interaction between NADP(H) and a bacterial ferredoxin-NADP reductase. Rosario. 15/11/06 6th Ibero-American Congress of Biophysics. Participativo - Póster. Caracterización de cooperatividad de unión en proteínas mediante calorimetría isoterma de titulación: Análisis de efectos heterotrópicos en ferredoxina-NADP+-reductasa de Anabaena PCC 7119. Madrid. 24/09/06 6th European Federation of EPR groups Meeting. Participativo - Póster. ESEEM and HYSCORE of human phenylalanine hydroxilase. Madrid. 05/09/06 Protein Society Annual Meeting 2006. Participativo - Póster. Interaction and Electron Transfer between Flavodoxin and Ferredoxin-NADP+ Reductase: Role of Hydrophobic Surface in FMN Environment. San Diego. 05/08/06 Protein Society Annual Meeting 2006. Participativo - Póster. FAD synthetase from Corynebacterium ammoniagenes: sequence and preliminary structural and functional analysis. San Diego. 05/08/06 American Crystallographic Association Annual Meeting 2006. Participativo - Póster. Structural studies on a NADP+/H dependent oxidorreductase contributes to investigate coenzyme specificity. Honolulu. 22/07/06 Applications in BioCalorimetry. Participativo - Póster. Analysis of heterotrophic effects in substrates binding to Anabaena PCC 7119 Ferredoxin-NADP+ Reductase by Isothermal Titration Calorimetry. Zaragoza. 04/07/06 9th Congress of the International Network of Protein Engineering Centers INPEC 2006. Participativo - Ponencia oral (comunicación oral). Protein engineering of redox proteins: applications to nanotechnology. Elsinore. 16/06/06 Bifi 2006. II International Conference. From Physics to Biology. The interface between experiment and computation. Participativo - Póster. Rolo of hydrophobic surface residues on Anabaena flavodoxin in the interaction and electron trasnfer with ferredoxin-NADP+ reductase. Zaragoza. 08/02/06 Bifi 2006. II International Conference. From Physics to Biology. The interface between experiment and computation. Participativo - Póster. Molecular dynamics simulation of the ferredoxin-NADP+ reductase catalytic mechanism. Zaragoza. 08/02/06 Bifi 2006. II International Conference. From Physics to Biology. The interface between experiment and computation. Participativo - Póster. Design of a hybrid electron transfer system using proteins from the photosynthetic electron transfer chain and the steroid hormone production system. Zaragoza. 08/02/06 Bifi 2006. II International Conference. From Physics to Biology. The interface between experiment and computation. Participativo - Póster. Phylogenetic analysis of the FAD synthetase family. Zaragoza. 08/02/06 Bifi 2006. II International Conference. From Physics to Biology. The interface between experiment and computation. Participativo - Póster. Characterisation of FAD synthetase from Corynebacterium ammoniagenes, a bifunctional enzyme involved in flavin metabolism. Zaragoza. 08/02/06 INPEC Meeting 2005. Participativo - Ponencia oral (comunicación oral). Protein engineering to study the interaction between Ferredoxin NADP+ reductase and Feredoxin (or Flavodoxin). Ein-Gedi. 09/11/05 INPEC Meeting 2005. Participativo - Póster. Versatility of the flavin isoalloxazine ring as redox centre in electron transfer in proteins. Ein-Gedi. 09/11/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudio estructura-función de un mutante de cambio de especificidad de la FNR de Anabaena PCC 7119. Zaragoza. 12/09/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Análisis del papel catalítico de la Tyr303 de la FNR de Anabaena PCC 7119 mediante dinámica molecular. Zaragoza. 12/09/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudio estructural del mecanismo de unión y reconocimiento del NADP+ en la FNR de Anabaena. Zaragoza. 12/09/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Diseño de un sistema enzimático mixto de la cadena de Transporte electrónica fotosintética y la que dirigie a la síntesis de hormonas esteroides. Zaragoza. 12/09/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudio de los determinantes cinéticos y termodinámicos en la interacción entre flavodoxina y FNR. Zaragoza. 12/09/05 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Caracterización de la FAD sintetasa de Corinebacterium ammoniangenes. Zaragoza. 12/09/05 Biotechnology for pulp and paper manufacture: from tailor-made biocatalysts to mill application. Participativo - Póster. Structure-Function Studies of the Flavoenzyme Aryl-Alcohol Oxidase. Baiona. 26/04/05 15th International symposium on flavins and flavoproteins. Participativo - Póster. Structural model for the FAD synthetase from Brevibacterium ammoniagenes. Hayama. 17/04/05 15th Intern.Symp.on Flavins and Flavoproteins. Participativo - Póster. Effect of the substitution of the 8-methyl group for a 8-Cl in the FMN in the redox properties of flavodoxin from Anabaena PCCC 7119. Hayama. 17/04/05 15th Intern.Symp.on Flavins and Flavoproteins. Participativo - Póster. Kinetic studies of Aryl-alcohol oxidase from P. eryngii. Hayama. 17/04/05 15th Intern.Symp.on Flavins and Flavoproteins. Participativo - Póster. Revisiting the catalytic mechanism of interaction and electron transfer between Flavodoxin and Ferredoxin NADP+-Reductase by fast kinetic methods. Hayama. 17/04/05 15th Intern.Symp.on Flavins and Flavoproteins. Participativo - Póster. Study of Anabaena PCC 7119 Apoflavodoxin stability by Fluorescence Resonance Energy Transfer (FRET). Hayama. 17/04/05 15th Intern.Symp.on Flavins and Flavoproteins. Participativo - Póster. Structural model of the FAD synthetase from Corynebacterium ammoniagenes. Hayama. 17/04/05 II Congreso Nacional BIFI 2005. Participativo - Póster. Determination of the importante of candidate residues on Anabaena Flavodoxin surface in the interaction and electrón transfer with ferredoxin-NADP+ reductase. Zaragoza. 10/02/05 II Congreso Nacional BIFI 2005. Participativo - Póster. 8-Cl-FMN Flavodoxina de Anabaena PCC 7119: Propiedades redox y energética de unión del grupo prostético. Zaragoza. 10/02/05 II Congreso Nacional BIFI 2005. Participativo - Póster. Revisión de los mecanismos de interacción y transferencia electrónica entre Ferredoxina NADP+ Reductasa y Flavodoxina mediante cinéticas de mezcla rápida con flujo detenido. Zaragoza. 10/02/05 II Congreso Nacional BIFI 2005. Participativo - Ponencia oral (comunicación oral). Cristalografía y difracción de rayos X; técnica aplicada a la resolución de estructuras tridimensionales de proteínas dependientes de flavina. Zaragoza. 10/02/05 II Congreso Nacional BIFI 2005. Participativo - Póster. Análisis por dinámica molecular del entorno del FAD de la FNR de Anabaena y sus implicaciones catalíticas. Zaragoza. 10/02/05 II Congreso Nacional BIFI 2005. Participativo - Póster. Building a model for the three-dimensional structure of FAD synthetase from Brevibacterium ammoniagenes. Zaragoza. 10/02/05 XL Annual Meeting Argentine Society for Biochemistry and Molecular Biology. Participativo - Póster. Is any residue on Anabaena flavodoxin surface critical for the interaction and electron transfer with ferredoxin-NADP+reductase. Iguazú. 05/12/04 International Network of Protein Engineering Centers INPEC 2004. Participativo - Póster. Change of specificity by protein engineering techniques: The case of ferredoxin-NADP+ reductase. Brunnen. 22/09/04 XXVII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudio del papel catalítico del entrono del FAD de la FNR de Anabaena PCC 7119 por medio de dinámica molecular. Lleida. 12/09/04 XXVII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Implicación de residuos con carga e hidrofóbicos de la flavodoxina de Anabaena PCC 7119 en la modulación del potencial redox del FMN. Lleida. 12/09/04 XXVII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. En busca de los residuos claves para la formación de un complejo productivo entre flavodoxyna y su sustrato natural, la ferredoxina-NADP+ reductasa de Anabaena PCC 7119. Lleida. 12/09/04 13th Internacional Congress of Photosynthesis. Participativo - Póster. Role of Anabaena flavodoxin hydrophobic residues in protein-protein interaction and electron transfer to ferredoxin-NADP+ reductase. Montreal. 30/08/04 13th Internacional Congress of Photosynthesis. Participativo - Póster. Specificity for the coenzyme in ferredoxin- NADP+ reductase: an attempt to create a NAD+/H dependent enzyme. Montreal. 30/08/04 29th FEBS Congress. Participativo - Póster. Structural and functional analysis of the FAD synthetase from Brevivacterium ammoniagenes. Varsovia. 26/06/04 29th FEBS Congress. Participativo - Póster. Catalytic mechanism of the atypical ferredoxin (flavodoxin) – NADP(H) reductase from the phototropic bacterium Rhodobacter capsulatus. Varsovia. 26/06/04 BIFI 2004. I International Conference. Biology after the Genome: a Physical view. Participativo - Póster. Towards a new interaction enzyme:coenzyme. Zaragoza. 11/02/04 BIFI 2004. I International Conference. Biology after the Genome: a Physical view. Participativo - Póster. Anabaena PCC 7119 Apoflavodoxin folding analysis by fluorescent dyes. Zaragoza. 11/02/04 XXIII Reunión anual de la Sociedad de Biología de Rosario. Participativo - Póster. Papel de los residuos E16, W57, I59 e I92 de la Flavodoxina de Anabaena en los procesos de interacción electrostáticos e hidrofóbicos y de transferencia de electrones con la Ferredoxina- NADP+ reductasa. Rosario. 04/12/03 XXIII Reunión anual de la Sociedad de Biología de Rosario. Participativo - Póster. Implicación de algunos residuos de la enzima Ferredoxina- NADP+ reductasa (FNR) en la especificidad por el coenzima; aproximación bioquímica y estructural. Rosario. 04/12/03 XXIII Reunión anual de la Sociedad de Biología de Rosario. Participativo - Póster. Implicación de algunos residuos de la flavodoxina de Anabaena en la modulación de los potenciales de reducción del FMN y de la unión de este a la apoproteína. Rosario. 04/12/03 Argentine Society for Biochemistry and Molecular Biology XXXIX Annual Meeting. Biophysical Society of Argentina XXXII Annual Meeting. Participativo - Póster. The oxidant-responsive diaphorase of Rhodobacter capsulatus is a ferredoxin-(flavodoxin)-NADP(H) reductase. Bariloche. 17/11/03 I Luso-Spanish Workshop on the Structure and Function of Proteins. Participativo - Póster. Role of residues Glu20, Thr56, Asn58, Asp65, Asp96 y Asn97 from Anabaena Flavodoxinin the binding of the apoprotein to FMN and in the modulation of FMN redox potential. A Coruña. 18/09/03 I Luso-Spanish Workshop on the Structure and Function of Proteins. Participativo - Póster. The reaction of Ferredoxin- NADP+ reductase with NADP+/H. Effect of mutations on reactions intermediates. A Coruña. 18/09/03 I Luso-Spanish Workshop on the Structure and Function of Proteins. Participativo - Póster. Biochemical and Structural basis of the change of specificity for the coenzyme inFerredoxin- NADP+ reductasa. A Coruña. 18/09/03 I Luso-Spanish Workshop on the Structure and Function of Proteins. Participativo - Póster. Role of candidate residues onFlavodoxin surface from Anabaena PCC 7119 in the interaction and electrón transfer with Ferredoxin- NADP+ reductasa. A Coruña. 18/09/03 I Luso-Spanish Workshop on the Structure and Function of Proteins. Participativo - Póster. Apoflavodoxin labelling with fluorescent and paramagnetic dyes. A Coruña. 18/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Estudios cinéticos de la reacción de la Ferredoxina- NADP+ reductasa de Anabaena con NADP+/H: Efecto de mutaciones en los intermediarios de reacción. A Coruña. 15/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Bases estructurales del reconocimiento y unión a la coenzima: estructura del complejo entre FNR y NADP+. A Coruña. 15/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Papel de los residuos Glu20, Thr56, Asn58, Asp65, Asp96 y Asn97 de la Flavodoxina de Anabaena en la unión de la apoproteína al FMN y en la modulación de los potenciales de oxidoreducción del FMN. A Coruña. 15/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Bases Bioquímica y estructurales del cambio de la especificidad por el coenzima de la Ferredoxin-NADP+ reductasa. A Coruña. 15/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Marcaje de apoflavodoxina de Anabaena PCC 7119 con sondas fluorescentes y paramagnéticas. A Coruña. 15/09/03 XXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Estudio de la implicación de los residuos E16, W57, I59 e I92 de Flavodoxina de Anabaena PCC 7119 en el proceso de interacción y transferencia de de electrones con la Ferredoxina-NADP+ reductasa. A Coruña. 15/09/03 5th Meeting of the European Federation of EPR Groups. Participativo - Póster. Pulsed EPR studies of Human Phenylalanine Hydroxilase. Lisboa. 07/09/03 XXV Congreso de la Sociedad Española de Bioquimica y Biologia Molecular (SEBBM). Participativo - Póster. Implicación de las regiones de interacción de la Ferredoxina-NADP+ reductasa de Anabaena PCC 7119 con los grupos pirofosfato y nicotinamida del piridín nucleótido (NADP+/H y NAD+/H) como determinantes de la especificidad por el coenzima. León. 17/09/02 XXV Congreso de la Sociedad Española de Bioquimica y Biologia Molecular (SEBBM). Participativo - Póster. Papel de los residuos Thr56, Asn58 y Asn97 de la Flavodoxina de Anabaena en los procesos de transferencia de electrones con Ferredoxina-NADP+ reductasa. León. 17/09/02 XXV Congreso de la Sociedad Española de Bioquimica y Biologia Molecular (SEBBM). Participativo - Póster. Análisis teórico de la distribución de la densidad electrónica de espín del anillo de isoaloxazina en proteínas al modificar sus sustituyentes. León. 17/09/02 14th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Role of the Carboxyl-terminal Tyrosine of Ferredoxin-NADP+ Reductase in the Electron Transfer Processes with the Protein Carriers Ferredoxin and Flavodoxin. Cambridge. 14/07/02 14th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Theoretical Analysis of the Changes Introduced in the Electron Spin Density Distribution of the Neutral Flavin Semiquinone Isoalloxazine Ring upon Modification of the Isoalloxazine Ring. Cambridge. 14/07/02 14th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Involvement of the Pyrophosphate and Nicotinamide Binding Regions of Anabaena PCC 7119 Ferredoxin-NADP+ Reductase in Coenzyme Specificity. Cambridge. 14/07/02 14th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Role of Residues Thr56, Asn58 and Asn97 from Anabaena Flavodoxin in Electron Transfer Processes with Ferredoxin-NADP+ Reductase. Cambridge. 14/07/02 14th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Electron Transfer in the Hybrid System between Anabaena Ferredoxin-NADP+ Reductase and Bovine Adrenodoxin. Cambridge. 14/07/02 5th Meeting on the Recent Advances and Applications of EPR. Participativo - Póster. EPR and ESEEM of model compounds for hemerproteins. París. 07/05/02 International Network of Protein Engineering Centers INPEC 2001. Participativo - Ponencia oral (comunicación oral). Electron transfer studied by protein engineering: the ferredoxin/ferredoxin NADP+ reductase system. St. Goar. 20/10/01 XXIV Congreso de la Sociedad Española de Bioquimica y Biologia Molecular (SEBBM). Participativo - Ponencia invitada/ Keynote. Versatilidad del anillo de isoaloxazina como centro redox: implicaciones en procesos de transferencia de electrones entre proteínas. Valencia. 18/09/01 XXIV Congreso de la Sociedad Española de Bioquimica y Biologia Molecular (SEBBM). Participativo - Póster. Importancia de las interacciones hidrofóbicas y electrostáticas, entre ferredoxina-NADP+ reductasa y sus donadores electrónicos. Valencia. 18/09/01 I CONGRESO Nacional del Instituto de Biocomputación y Física de los Sistemas Complejos. BIFI-2003. Participativo - Ponencia oral (comunicación oral). Using computing tools to analyse the structure-function relationship in cofactor dependent proteins. Zaragoza. 08/09/01 10th International Conference on Bioinorganic Chemistry. Participativo - Ponencia invitada/ Keynote. Kinetic and structural studies have revealed the nature of the interface area between ferredoxin and ferredoxin-NADP+ reductase. Florencia. 26/08/01 27th Meeting of the Federation of European Biochemical Societies. Participativo - Póster. Wild-type and mutant flavodoxin reduction by Photosystem I in the cyanobacterium Anabaena PCC 7119. Lisboa. 30/06/01 IV Congreso Internacional de Química. XIII Conferencia del Caribe de Química e Ingeniería Química. Participativo - Ponencia invitada/ Keynote. Mecanismo de Transporte de electrones entre proteínas que forman complejos. La Habana. 16/04/01 XXIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Análisis de la especificidad de la Ferredoxina-NADP+ reductasa hacia la coenzima mediante mutagénesis dirigida. Granada. 13/09/00 XXIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Papel de las interacciones hidrofóbicas en la estabilización de los complejos FNR-proteína transportadora de electrones. Granada. 13/09/00 XXIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Participativo - Póster. Estudio de la reacción de la Ferredoxina-NADP+ reductasa de Anabaena Pcc 7119 con NADPH y NADH: Análisis cinético y caracterización de intermedios de reacción. Granada. 13/09/00 9th Congress of the International Network of Protein Engineering Centers INPEC 2000. Participativo - Póster. Hybrid electron transfer chains between homologous vertebrate and cyanobacterial electron transfer systems. Groningen. 24/07/00 9th Congress of the International Network of Protein Engineering Centers INPEC 2000. Participativo - Ponencia oral (comunicación oral). Mechanism of electron transfer deduced from protein engineering studies. Groningen. 24/07/00 44th Annual Meeting of the Biophysical Society. Participativo - Póster. Non-productive complexes with Anabaena Ferredoxin are induced by mutations at Glu139 in Anabaena Ferredoxin-NADP+ reductase at low ionic strength. Nueva Orleans. 12/02/00 International Network of Protein Engineering Centers Annual Meeting INPEC 1999. Participativo - Ponencia oral (comunicación oral). Protein engineering for the elucidation of the mechanism of electron transfer reactions in protein-protein complexes. Versalles. 18/11/99 XIII Reunión de la Sociedad Española de Fisiología Vegetal y VI CONGRESO Hispano-Luso de Fisiología Vegetal. Participativo - Póster. Transferencia de electrones desde el fotosistema I a la flavodoxina: estudio cinético de mutantes de la flavoproteína. Sevilla. 19/09/99 XXII CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Bases estructurales de la catálisis en la FNR: Estructura tridimensional del mutante E301A. Pamplona. 14/09/99 XXII CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Estudio estructural de la interacción Ferredoxina-NADP+ reductasa y la Flavodoxina. Pamplona. 14/09/99 XXII CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Análisis de las reacciones de la Ferredoxina-NADP+ reductasa de Anabaena PCC 7119 con sus sustratos. Pamplona. 14/09/99 13th International Congress on Flavins and Flavoproteins. Participativo - Póster. Advanced EPR spectroscopic studies of ferredoxin-NADP+ reductase mutants from pea. Konstanz. 29/08/99 13th International Congress on Flavins and Flavoproteins. Participativo - Póster. Role of glutamic acid 139 in the catalytic mechanism of ferredoxin-NADP+ reductase from Anabaena PCC 7119. Konstanz. 29/08/99 13th International Congress on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Molecular recognition between Ferredoxin-NADP+ reductase and its protein partners. Konstanz. 29/08/99 13th International Congress on Flavins and Flavoproteins. Participativo - Póster. Determinants of Cofactor Specificity in Anabaena PCC 7119 Ferredoxin-NADP+ reductase. Konstanz. 29/08/99 13th International Congress on Flavins and Flavoproteins. Participativo - Ponencia oral (comunicación oral). Crystallographic studies of a complex between the Ferredoxin-NADP+ reductase from the cyanobacterium Anabaena PCC 7119 and its functional partner. Konstanz. 29/08/99 2nd Portuguese-Spanish Biophysics Congress y VI Congreso de la Sociedad de Biofísica de España. Participativo - Ponencia oral (comunicación oral). ENDOR and HYSCORE characterization of flavoprotein semiquinones in relation to protein function. Madrid. 04/12/98 2nd Portuguese-Spanish Biophysics Congress y VI Congreso de la Sociedad de Biofísica de España. Participativo - Póster. Análisis estructural mediante cristalografia de Rayos X de una zona hidrogóbica de reconocimiento entre ferredoxina y ferredoxina-NADP+ reductasa. Madrid. 04/12/98 XXI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Ponencia oral (comunicación oral). Estudio de la interacción del enzima ferredoxina-NADP+ reductasa con sus sustratos proteínicos mediante análisis cinético de mutantes. Sevilla. 20/09/98 XXI Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Participativo - Póster. Análisis estructural mediante cristalografía de rayos X de las zonas de reconocimiento entre ferredoxina y ferredoxina-NADP+ reductasa. Sevilla. 20/09/98 4th European Biological Inorganic Chemistry Conference. EUROBIC 4. Participativo - Ponencia invitada/ Keynote. Structural bases of the mechanism of electron and proton transfer in protein-protein and protein-substrate complexes. Sevilla. 20/07/98 4th European Biological Inorganic Chemistry Conference. EUROBIC 4. Participativo - Ponencia oral (comunicación oral). Structural bases of the mechanism of protein-protein complexes in electron transfer reactions. Sevilla. 20/07/98 4th European Biological Inorganic Chemistry Conference. EUROBIC 4. Participativo - Póster. Structural and magnetic characterisation of the haem core of ferricytochromes c6. Sevilla. 20/07/98 14th International Symposium on Bioelectrochemistry and Bioenergetics. Participativo - Ponencia oral (comunicación oral). On the mechanism of electron transfer reactions in protein-protein complexes. Vingstedcentret. 23/05/98 Franco-Hispano-Italian Meeting of Biochemistry and Molecular Biology. Participativo - Ponencia oral (comunicación oral). Protein-protein interaction in electron transfer reactions. Marsella. 27/04/98 Franco-Hispano-Italian Meeting of Biochemistry and Molecular Biology. Participativo - Póster. Lys75 of Anabaena Ferredoxin-NADP+ Reductase is a Critical Residue for Binding Ferredoxin and Flavodoxin During Electron Transfer. Marsella. 27/04/98 XXI CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Análisis estructural mediante cristalografia de Rayos X de las zonas de reconocimiento entre ferredoxina y ferredoxina-NADP+ reductasa. Sevilla. 12/03/98 XXI CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Estudio de la interacción del enzima ferredoxina-NADP+ reductasa con sus sutratos proteinicos mediante análisis cinético de mutantes. Sevilla. 12/03/98 Workshop on Molecular Recognition in Metalloproteins. European Science Foundation. Participativo - Póster. Crystallographic studies of the interaction between Ferredoxina-NADP+ Reductasa and its functional partners. Sevilla. 23/10/97 Workshop on Molecular Recognition in Metalloproteins. European Science Foundation. Participativo - Ponencia oral (comunicación oral). The Ferredoxin-NADP+ reductase system: a model for the study of protein-protein recognition and electron transfer. Sevilla. 23/10/97 Workshop on Molecular Recognition in Metalloproteins. Programme on Chemistry of Metals in Biological Systems. European Science Foundation. Participativo - Ponencia oral (comunicación oral). The Ferredoxin-NADP+ reductase system: a model for the study of protein-protein recognition and electron transfer. Sevilla. 23/10/97 XX CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Ferredoxina/flavodoxina y FNR: un sistema para el estudio del reconocimiento proteína-proteína y la transferencia de electrones. Madrid. 20/09/97 XX CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Ponencia oral (comunicación oral). Bases Estructurales del Transporte de Electrones entre proteínas. Madrid. 20/09/97 XX CONGRESO Sociedad Española de Bioquímica y Biología Molecular y Celular. Participativo - Póster. Determinantes de la especificidad de la ferredoxina-NADP+ reductasa de Anabaena PCC 7119 por los coenzimas NADP(H) y NAD(H). Madrid. 20/09/97 39th Rocky Mountain Conference. 20th International EPR Symposium. Participativo - Ponencia oral (comunicación oral). ENDOR and HYSCORE characterization of flavoprotein semiquinones in relation to protein function. Denver. 30/07/97 German Biological Society Meeting on Radicals. Participativo - Ponencia oral (comunicación oral). ENDOR studies of flavin radicals in enzymes. Tübingen. 13/04/97 Second FLAPS Meeting. Participativo - Ponencia oral (comunicación oral). Mechanism of NADP+ binding and electron transfer to Ferredoxin-NADP+ reductase from Anabaena. Wageningen. 04/10/96 Red Nacional sobre Plegamiento de Proteínas. Participativo - Otros. Tarazona. 05/05/96 First Portuguese-Spanish Biophysics Congress. Participativo - Póster. Cytochrome c6 from the cyanobacterium Anabaena PCC 7119. Biochemical and Biophysical characterization. Lisboa. 04/12/95 University College Dublin Meeting, The Biochemical Society. Participativo - Póster. Crystal structures of a Ferredoxin-NADP+ reductase and of a complex with NADP+. Dublin. 11/09/95 7th International Conference on Bioinorganic Chemistry. Participativo - Póster. Kinetic studies on light-induced EPR signals in [NiFe]- and [NiFeSe]-hydrogenases. Lübeck. 03/09/95 First NSR Workshop on Advanced EPR Spectroscopy. Participativo - Ponencia oral (comunicación oral). Kinetic studies on light-induced EPR signals in [NiFe]- and [NiFeSe]-hydrogenases. Nijmegen. 01/06/95 ESR Spectroscopy of Radicals in Organic and Bio-Organic Systems. Participativo - Ponencia oral (comunicación oral). Aplication of the electron spin echo envelope modulation techniques to the study of flavoprotein semiquinones. Guildford. 27/03/95 European ESR Meeting on Recent Advances and Applications to Organic and Bio-organic Materials. Participativo - Ponencia oral (comunicación oral). ESEEM and ENDOR in biological membranes and enzymes. París. 05/09/94 4th International Conference on the Molecular Biology of Hydrogenases. Participativo - Póster. Kinetic studies on light-induced nickel EPR signals in hydrogenase. Noordwijkerhout. 14/08/94 4th International Conference on the Molecular Biology of Hydrogenases. Participativo - Póster. Influence of illumination on the magnetic interactions between the Ni site and the [4Fe-4S] clusters in active Desulfovibrio gigas hydrogenase. Noordwijkerhout. 14/08/94 4th International Conference on the Molecular Biology of Hydrogenases. Participativo - Ponencia oral (comunicación oral). The other protons in hydrogenase - X-band ENDOR studies on the metal centres. Noordwijkerhout. 14/08/94 ESR Group Meeting. Participativo - Póster. Studies of light-induced nickel in hydrogenase: comparison of enzymes with and without selenium. Cardiff. 25/04/94 IV Congreso de la Sociedad de Biofísica de España. Participativo - Ponencia oral (comunicación oral). Propiedades del átomo de niquel en hidrogenasas. Cáceres. 07/04/94 II British/Spanish Joint Membranes Group Discussion. Participativo - Póster. ESR and ENDOR characterization of flavodoxin from Anabaena sp PCC 7119. Londres. 05/10/93 11th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Amino acid residues in Anabaena ferredoxin crucial to interaction with ferredoxin-NADP+ reductase: site directed mutagenesis and laser flash photolysis. Nagoya. 27/07/93 11th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Structural study of Ferredoxin-NADP+ reductase from Anabaena PCC 7119 and of its complex with NADP+. Nagoya. 27/07/93 Meeting on Inorganic Chemistry towards Europe. Participativo - Póster. Mechanims of electron transport in ferredoxin and flavoproteins using chemical modification and site-directed mutagenesis. Algarve. 24/03/92 III Congreso de la Sociedad de Biofísica de España. Participativo - Póster. Transporte de electrones mediante interacción proteína-proteína. Madrid. 04/12/91 Workshop on Structure and Function of Mutated Proteins. Participativo - Póster. Interprotein electron transfer between specifically modified Ferredoxin-NADP+ reductase and ferredoxin or flavodoxin. Florencia. 08/06/91 2nd European Workshop on Crystallography of Biological Macromolecules. Participativo - Póster. Preliminary study of Ferredoxin-NADP+reductase from Anabaena. Como. 13/05/91 10th International Symposium on Flavins and Flavoproteins. Participativo - Póster. Structural analysis of the requirements for the formation of an electron transfer complex. Como. 01/06/90 2ª Reunión Horizontal del BAP (Biotechnology Action Program) de las Comunidades Europeas. Participativo - Póster. Structural analysis of the requirements for the formation of a complex between Ferredoxin-NADP+reductase and flavodoxin. Troia. 22/11/89 XVI CONGRESO Nacional de Bioquímica. Participativo - Póster. Análisis estructural de Flavoproteínas de oxido/reducción. Alicante. 01/10/89 International XIX FEBS Meeting. Participativo - Póster. Interaction between Ferredoxin-NADP+reductase and flavodoxin: chemical modification and cross-linking studies. Roma. 19/06/89 Reunión Horizontal del BAP (Biotechnology Action Program) de las Comunidades Europeas. Participativo - Póster. Electron transfer in complexes of Ferredoxin-NADP+reductase and ferredoxin or flavodoxin from Anabaena. Creta. 17/05/89 Estancias KINGS COLLEGE. UNIVERSITY OF LONDON. LONDRES. Reino Unido. 01/01/93 - 31/12/95 DEPARTMENT OF BIOCHEMISTRY. UNIVERSITY OF ARIZONA. TUCSON. Estados Unidos de América. 01/05/92 - 10/07/92 DEPARTMENT OF BIOCHEMISTRY. UNIVERSITY OF ARIZONA. TUCSON. Estados Unidos de América. 20/01/91 - 20/03/91 Comités FEBS Advance Courses. Federation of European Biochemical Societies. 01/01/23 Comité Técnico Evaluación Proyectos 2020 “Generación de Conocimiento” y “Retos”, AEI. Agencia Estatal de Investigación. 22/04/21 - 23/04/21 Junta Ejecutiva de La Sociedad de Biofísica de España. Sociedad de Biofísica de España. 31/05/18 - 20/06/22 Comité Técnico Evaluación Proyectos 2017 “Excelencia” y “Retos”, del Plan Estatal 2013-2016. COMITÉ TÉCNICO. DIRECCIÓN GENERAL DE INVESTIGACIÓN CIENTÍFICA Y TÉCNICA. MINECO. 03/07/17 - 17/10/17 Organizaciones de actividades de I+D+i 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). 05/09/23 - 08/03/24 20th Sympsium on Flavins and Flavoproteins. Graz. Austria. 11/07/21 - 18/07/21 7th International Iberian Biophysics Congress. Coimbra. Portugal. 17/06/20 - 19/06/20 IX International Conference Bifi 2020. New Challenges in Molecular Biotechnology. Zaragoza. Spain. 03/02/20 - 05/02/20 19th International Symposium on Flavins and Flavoproteins. Groningen. The Netherlands. 02/07/17 - 07/07/17 Curso Extraordinario Estructura y Función de Proteínas. V Edición. 06/07/15 - 10/07/15 18th International Symposium on Flavins and Flavoproteins. Pechaburi. Thailand. 27/07/14 - 31/07/14 IV International Conference Bifi 2012. 01/02/12 - 04/02/12 IV National Spanish-Luso Biophysics Meeting. 07/07/10 - 11/07/10 IV National Conference Bifi 2009. 05/02/09 - 07/02/09 16th Sympsium on Flavins and Flavoproteins. 08/06/08 - 13/06/08 INPEC (International Network of Protein Engineering Centres) 2007. 16/06/07 - 19/06/07 VII Spanish Symposium on Bioinformatics and Computacional Biology. 20/11/06 - 22/11/06 XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. 12/09/05 - 15/09/05 Gestiones de actividades de I+D+i Universidad de Zaragoza. Investigador Principal Grupo de Acción Campus Iberus Bio-DTF. 01/09/20 Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos. Subdirector Instituto de Investigación. 11/02/19 - 01/11/23 Universidad de Zaragoza. Representante de IP Grupos de Investigación en Comisión de Investigación de la Universidad de Zaragoza. 14/05/18 Facultad de Ciencias. Coordinadora Grado en Biotecnología. 02/02/15 - 22/01/19 Universidad de Zaragoza. Presidente Comisión Evaluación de la Calidad en Grado en Biotecnología. 02/02/15 - 22/01/19 Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos. DIRECTORA EN FUNCIONES. 07/01/11 - 07/02/11 Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos. SUBDIRECTORA. 11/02/09 - 05/01/11 DEPARTAMENTO DE BIOQUIMICA Y BIOLOGIA MOLECULAR Y CELULAR. FACULTAD DE CIENCIAS. PROFESORA SECRETARIA. 01/09/04 - 18/12/06 Evaluaciones en artículos I+D+i Participación en tribunales. Tibunal Concurso Contratado Doctor. Universidad de Zaragoza. España. 18/03/21 - 18/03/21 Participación en tribunales. Tibunal Concurso Contratado Doctor. Universidad de Zaragoza. España. 22/06/20 - 22/06/20 Adquisición de Equipamieto Cientifico-Tecnico 2019. Evaluador Subdivisión de Coordinación y Evaluación de la Agencia Estatal de Investigación. España. 05/08/19 - 16/09/19 Evaluación Contratos Torres Quevedo 2018. Evaluador Subdivisión de Coordinación y Evaluación de la Agencia Estatal de Investigación. España. 01/07/19 - 31/07/19 Evaluación Contratos Doctorado Industrial 2018. Evaluador Subdivisión de Coordinación y Evaluación de la Agencia Estatal de Investigación. España. 01/07/19 - 26/07/19 Participación en tribunales. Tribunal Concurso Oposición Contratado Dotor. Universidad de Zaragoza. España. 11/04/19 - 12/04/19 Participación en tribunales. Tribunal Concurso Oposición Titular de Universidad. UAM. España. 28/03/19 - 28/03/19 Participación en tribunales. Tribunal Concurso Oposición para la Selección Investigador Científico - CSIC. España. 04/03/19 - 04/03/19 Participación en tribunales. Tribunal Concurso Oposición Titular de Universidad. Universidad de Zaragoza. España. 14/01/19 - 14/01/19 Evaluador. Proyectos Plan Nacional Excelencia y Retos 2017. España. 14/08/17 - 06/11/17 Participación en tribunales. Tribunal Concurso Oposición Catedrático de Universidad. Universidad de Zaragoza. España. 01/06/17 - 01/06/17 Participación en tribunales. Tribunal Concurso Oposición Contratado Dotor. Universidad de Zaragoza. España. 01/05/16 - 01/05/16 Participación en tribunales. Tribunal Concurso Oposición Catedrático de Universidad. Universidad de Sevilla. España. 01/06/12 - 01/06/12 Participación en tribunales. Tribunal Concurso Oposición Titular de Universidad. Universidad de Zaragoza. España. 01/09/09 - 01/09/09 Participación en tribunales. Tribunal para una plaza de Contratado Doctor Universidad de Sevilla. España. 01/09/08 - 01/09/08 Otros méritos Utilización de equipos. Espectroscopia de Resonancia Paramagnética de Electrón, EPR. Espectroscopia de Doble Resonancia Electrón-Núcleo, ENDOR. Espectroscopia de Resonancia Paramagnética de Electrón Pulsada Espectrofotometría Ultravioleta-Visible Espectroscopia de Dicroismo Circular y Fluorescencia Stopped-flow. Aparato de medida de cinéticas rápidas Laser flash photolysis Cromatografía de Gases Cromatografía líquida de alta presión. (HPLC, FPLC) Cluster Linux. Simulaciones Moleculares . 03/01/18 Proyecto Tutor. Tutora en la Facultad de Ciencias dentro del Proyecto Tutor. 2010-2011, 2011-12, 2012-2013, 2013-2014, 2014-2015, 2016-2017, 2017-2018, 2018-2019 40 hr/año. 15/09/10 Equipo de Gobierno del Instituto de Biocomputación y Física de los Sistemas Complejos. Investigador y Miembro del Equipo de Gobierno del Instituto de Biocomputación y Física de los Sistemas Complejos. 01/01/04 UNIZAR teaching activity Trabajo fin de master. Máster Universitario en Biofísica y Biotecnología Cuantitativa / Master in Biophysics and Quantitati. From the 2023-24 course to the 2024-25 course Biofísica. Graduado en Biotecnología. From the 2019-20 course to the 2024-25 course Técnicas avanzadas en biofísica. Máster Universitario en Biología Molecular y Celular. From the 2014-15 course to the 2024-25 course Bioinformática. Graduado en Biotecnología. From the 2012-13 course to the 2024-25 course Prácticas externas. Máster Universitario en Biofísica y Biotecnología Cuantitativa / Master in Biophysics and Quantitati. During academic year 2023-24 Trabajo fin de grado. Graduado en Biotecnología. During academic year 2023-24 Simulación de biomoléculas. Máster Universitario en Biofísica y Biotecnología Cuantitativa / Master in Biophysics and Quantitati. From the 2021-22 course to the 2022-23 course Técnicas instrumentales en biotecnología molecular. Máster Universitario en Biotecnología Cuantitativa. From the 2017-18 course to the 2020-21 course Biofísica. Graduado en Biotecnología. From the 2014-15 course to the 2015-16 course Técnicas instrumentales en biotecnología. Graduado en Biotecnología. From the 2011-12 course to the 2014-15 course Biofisica. Licenciado en Bioquímica. From the 1997-98 course to the 2014-15 course Proteínas: de la estructura a la función. Máster Universitario en Biología molecular y celular. From the 2009-10 course to the 2013-14 course Elements of biological physics. Máster Universitario en Física y tecnologías físicas. During academic year 2012-13 Simulando la naturaleza: los ordenadores y la ciencia. Actividades Académicas Complementarias, grado de experimentalidad 3. During academic year 2011-12 Fundamentos de metodologia bioquimica. Licenciado en Bioquímica. From the 1997-98 course to the 2010-11 course Elements of biological physics. Máster Universitario en Física y tecnologías físicas. During academic year 2009-10 Biofísica. Máster en biología molecular y celular. From the 2007-08 course to the 2008-09 course Elementos de física biológica. Máster en física y tecnologías físicas. From the 2006-07 course to the 2008-09 course Fundamentos de metodología bioquímica. Máster en biología molecular y celular. From the 2006-07 course to the 2008-09 course Selección y diseño de biomoléculas activas. Máster en biología molecular y celular. During academic year 2007-08 Ingenieria bioquimica. From the 1999-00 course to the 2004-05 course Caracterizacion espectroscopica de biomoleculas. From the 1998-99 course to the 2004-05 course Metodologia bioquimica I. From the 1999-00 course to the 2000-01 course Ingenieria bioquimica. During academic year 1998-99 Biologia general. During academic year 1997-98 Docencia no UNIZAR Espectroscopia. Doctorado en Biología y Biotecnología. Universita degli Studi di Bari. 14/05/2018 - 17/05/2018 Espectroscopia de biomoléculas**. Licenciaturas en Química, Biotecnología, Bioquímica y Farmacia. Universidad Nacional de Rosario. 01/08/2000 - 26/08/2000