Perfil (CV) del personal docente investigador

Artículos

• Soler-Agesta, R.; Moreno-Loshuertos, R.; Yim, C. Y.; Congenie, M. T.; Ames, T. D.; Johnson, H. L.; Stossi, F.; Mancini, M. G.; Mancini, M. A.; Ripollés-Yuba, C.; Marco-Brualla, J.; Junquera, C.; Martínez-De-Mena, R.; Enríquez, J. A.; Price, M. R.; Jimeno, J.; Anel, A. Cancer cell-selective induction of mitochondrial stress and immunogenic cell death by PT-112 in human prostate cell lines. JOURNAL OF TRANSLATIONAL MEDICINE. 2024. DOI: 10.1186/s12967-024-05739-x
  
  
• Guerrero-Ochoa, Patricia; Rodríguez-Zapater, Sergio; Anel, Alberto; Esteban, Luis Mariano; Camón-Fernández, Alejandro; Espilez-Ortiz, Raquel; Gil-Sanz, María Jesús; Borque-Fernando, Ángel. Prostate cancer and the Mevalonate pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. DOI: 10.3390/ijms25042152
  
  
• Beltrán-Visiedo, Manuel; Jiménez-Alduán, Nelia; Díez, Rosana; Cuenca, Marta; Benedi, Andrea; Serrano-del Valle, Alfonso; Azaceta, Gemma; Palomera, Luis; Peperzak, Victor; Anel, Alberto; Naval, Javier; Marzo, Isabel. Dinaciclib synergizes with BH3 mimetics targeting BCL-2 and BCL-XL in multiple myeloma cell lines partially dependent on MCL-1 and in plasma cells from patients. MOLECULAR ONCOLOGY. 2023. DOI: 10.1002/1878-0261.13522
  
  
• Gonzalo, Ó.; Benedi, A.; Vela, L.; Anel, A.; Naval, J.; Marzo, I. Study of the Bcl-2 Interactome by BiFC reveals differences in the activation mechanism of Bax and Bak. CELLS. 2023. DOI: 10.3390/cells12050800
  
  
• Reina-Ortiz, Chantal; Mozas, Mª Pilar; Ovelleiro, David; Gao, Fei; Villalba, Martín; Anel, Alberto. Dynamic Changes in miRNA Expression during the Generation of Expanded and Activated NK Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023. DOI: 10.3390/ijms241713556
  
  
• Soler-Agesta, Ruth; Marco-Brualla, Joaquín; Fernández-Silva, Patricio; Mozas, Pilar; Anel, Alberto; Moreno Loshuertos, Raquel. Transmitochondrial Cybrid Generation Using Cancer Cell Lines. JOURNAL OF VISUALIZED EXPERIMENTS : JOVE. 2023. DOI: 10.3791/65186
  
  
• Marco-Brualla, Joaquín; de Miguel, Diego; Martínez-Lostao, Luis; Anel, Alberto. DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL. JOURNAL OF CLINICAL MEDICINE. 2023. DOI: 10.3390/jcm12020608
  
  
• Soler Agesta, R.; Guerrero-Ochoa, P.; Marco-Brualla, J.; Ibáñez-Pérez, R.; Marzo, I.; Martínez Lostao, L.; Anel, A. Conjugation of the 9-kDa isoform of Granulysin with liposomes potentiates its cytotoxicity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022. DOI: 10.3390/ijms23158705
  
  
• Serrano del Valle, Alfonso; Beltrán-Visiedo, Manuel; de Poo-Rodríguez, Victoria; Jiménez-Alduán, Nelia; Azaceta, Gemma; Díez, Rosana; Martínez-Lázaro, Beatriz; Izquierdo, Isabel; Palomera, Luis; Naval, Javier; Anel, Alberto; Marzo, Isabel. Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis. ONCOIMMUNOLOGY. 2022. DOI: 10.1080/2162402X.2022.2141973
  
  
• Soler-Agesta, Ruth; Marco-Brualla, Joaquín; Minjárez-Sáenz, Martha; Yim, Christina Y.; Martínez-Júlvez, Marta; Price, Matthew R.; Moreno-Loshuertos, Raquel; Ames, Tyler D.; Jimeno, José; Anel, Alberto. PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies. CANCERS. 2022. DOI: 10.3390/cancers14163851
  
  
• Guerrero-Ochoa, Patricia; Ibáñez-Pérez, Raquel; Berbegal-Pinilla, Germán; Aguilar, Diederich; Marzo, Isabel; Corzana, Francisco; Minjárez-Sáenz, Martha; Macías-León, Javier; Conde, Blanca; Raso, Javier; Hurtado-Guerrero, Ramón; Anel, Alberto. Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment. BIOMEDICINES. 2022. DOI: 10.3390/biomedicines10061223
  
  
• Belkahla, Sana; Brualla, Joaquín Marco; Fayd'herbe de Maudave, Alexis; Falvo, Paolo; Allende-Vega, Nerea; Constantinides, Michael; Khan, Abrar Ul Haq; Coenon, Lois ; Alexia, Catherine; Mitola, Giulia; Massa, Paul; Orecchioni, Stefania; Bertolini, Francesco; Mnif, Wissem; Hernandez, Javier; Anel, Alberto; Villalba, Martin. The metabolism of cells regulates their sensitivity to NK cells depending on p53 status. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2022. DOI: 10.1038/s41598-022-07281-6
  
  
• Lapuente, J. P.; Gómez, G.; Marco-Brualla, J.; Fernández, P.; Desportes, P.; Sanz, J.; García-Gil, M.; Bermejo, F.; Martín, J. V. S.; Algaba, A.; de Gregorio, J. C.; Lapuente, D.; de Gregorio, A.; Lapuente, B.; Gómez, S.; de las Viñas Andrés, M.; Anel Bernal, A. Evaluation in a Cytokine Storm Model in Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells). BIOMEDICINES. 2022. DOI: 10.3390/biomedicines10051094
  
  
• Lapuente, J. P.; Blázquez-Martínez, A.; Marco-Brualla, J.; Gómez, G.; Desportes, P.; Sanz, J.; Fernández, P.; García-Gil, M.; Bermejo, F.; Martín, J. V. S.; Algaba, A.; de Gregorio, J. C.; Lapuente, D.; de Gregorio, A.; Lapuente, B.; de la Viñas Andrés, M.; Anel, A. Cytokine profile and anti-inflammatory activity of a standardized conditioned medium obtained by coculture of monocytes and mesenchymal stromal cells (PRS CK STORM). BIOMOLECULES. 2022. DOI: 10.3390/biom12040534
  
  
• Al-Wasaby, S.; Guerrero-Ochoa, P.; Ibáñez-Pérez, R.; Soler, R.; Conde, B.; Martínez-Lostao, L.; Anel, A. In vivo potential of recombinant granulysin against human melanoma. CANCER TREATMENT AND RESEARCH COMMUNICATIONS. 2021. DOI: 10.1016/j.ctarc.2021.100355
  
  
• Serrano-del Valle A.; Reina-Ortiz C.; Benedi A.; Anel A.; Naval J.; Marzo I. Future prospects for mitosis-targeted antitumor therapies. BIOCHEMICAL PHARMACOLOGY. 2021. DOI: 10.1016/j.bcp.2021.114655
  
  
• Reina-Ortiz, C.; Constantinides, M.; Fayd-Herbe-De-Maudave, A.; Présumey, J.; Hernandez, J.; Cartron, G.; Giraldos, D.; Díez, R.; Izquierdo, I.; Azaceta, G.; Palomera, L.; Marzo, I.; Naval, J.; Anel, A.; Villalba, M. Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients. ONCOIMMUNOLOGY. 2021. DOI: 10.1080/2162402X.2020.1853314
  
  
• Sanz, L.; Ibáñez-Pérez, R.; Guerrero-Ochoa, P.; Lacadena, J.; Anel, A. Antibody-based immunotoxins for colorectal cancer therapy. BIOMEDICINES. 2021. DOI: 10.3390/biomedicines9111729
  
  
• Mata, E; Tarancon, R; Guerrero, C; Moreo, E; Moreau, F; Uranga, S; Gomez, Ab; Marinova, D; Domenech, M; Gonzalez-Camacho, F; Monzon, M; Badiola, J; Dominguez-Andres, J; Yuste, J; Anel, A; Peixoto, A; Martin, C; Aguilo, N. Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis. SCIENCE IMMUNOLOGY. 2021. DOI: 10.1126/sciimmunol.abc2934
  
  
• Serrano-del Valle, A.; Naval, J.; Anel, A.; Marzo, I. Novel Forms of Immunomodulation for Cancer Therapy. TRENDS IN CANCER. 2020. DOI: 10.1016/j.trecan.2020.02.015
  
  
• Mata, E.; Farrell, D.; Ma, R.; Uranga, S.; Gomez, A.B.; Monzon, M.; Badiola, J.; Anel, A.; Gonzalo-Asensio, J.; Martin, C.; Gordon, S.V.; Aguilo, N. Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference. PLOS PATHOGENS. 2020. DOI: 10.1371/journal.ppat.1009061
  
  
• Calvo, T.; Reina-Ortiz, C.; Giraldos, D.; Gascón, M.; Woods, D.; Asenjo, J.; Marco-Brualla, J.; Azaceta, G.; Izquierdo, I.; Palomera, L.; Sánchez-Martínez, D.; Marzo, I.; Naval, J.; Vilches, C.; Villalba, M.; Anel, A. Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2020. DOI: 10.1038/s41598-020-76051-z
  
  
• Casamayor-Polo, L.; López-Nevado, M.; Paz-Artal, E.; Anel, A.; Rieux-Laucat, F.; Allende, L.M. Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS). CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. 2020. DOI: 10.1080/10408363.2020.1855623
  
  
• Anel, A.; Pardo, J.; Villalba, M. Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application. FRONTIERS IN IMMUNOLOGY. 2020. DOI: 10.3389/fimmu.2020.00872
  
  
• Guerrero-Ochoa, Patricia; Aguilar-Machado, D.; Ibáñez-Pérez, Raquel; Macías-León, Javier; Hurtado-Guerrero, Ramón; Raso, Javier; Anel, Alberto. Production of a granulysin-based, tn-targeted cytolytic immunotoxin using pulsed electric field technology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. DOI: 10.3390/ijms21176165
  
  
• de Miguel, Diego; Gallego-Lleyda, Ana; Martinez-Ara, Miguel; Plou, Javier; Anel, Alberto; Martinez-Lostao, Luis. Double-edged lipid nanoparticles combining liposome-bound TRAIL and encapsulated doxorubicin showing an extraordinary synergistic pro-apoptotic potential. CANCERS. 2019. DOI: 10.3390/cancers11121948
  
  
• Ibáñez-Pérez, Raquel; Guerrero-Ochoa, Patricia; Al-Wasaby, Sameer; Navarro, Rocío; Tapia-Galisteo, Antonio; de Miguel, Diego; Gonzalo, Óscar; Conde, Blanca; Martinez-Lostao, Luis; Hurtado-Guerrero, Ramón; Sanz, Laura; Anel, Alberto. Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin. ONCOIMMUNOLOGY. 2019. DOI: 10.1080/2162402X.2019.1641392
  
  
• Marco-Brualla, Joaquín; Al-Wasaby, Sameer; Soler, Ruth; Romanos, Eduardo; Conde, Blanca; Justo-Méndez, Raquel; Enríquez, José A.; Fernández-Silva, Patricio; Martínez-Lostao, Luis; Villalba, Martín; Moreno-Loshuertos, Raquel; Anel, Alberto. Mutations in the ND2 subunit of mitochondrial complex I are sufficient to confer increased tumorigenic and metastatic potential to cancer cells. CANCERS. 2019. DOI: 10.3390/cancers11071027
  
  
• Naval, Javier; Miguel, Diego De; Gallego-Lleyda, Ana; Anel, Alberto; Martinez-Lostao, Luis. Importance of TRAIL molecular anatomy in receptor oligomerization and signaling. Implications for cancer therapy. CANCERS. 2019. DOI: 10.3390/cancers11040444
  
  
• Serrano del Valle, Alfonso; Anel, Alberto; Naval, Javier; Marzo, Isabel. Immunogenic cell death and immunotherapy of multiple myeloma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019. DOI: 10.3389/fcell.2019.00050
  
  
• Anel, A.; Gallego-Lleyda, A.; de Miguel, D.; Naval, J.; Martinez-Lostao, L. Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease. CELLS. 2019. DOI: 10.3390/cells8020154
  
  
• Serrano del Valle A; Anel A; Naval J; Marzo I. Response: Commentary: Immunogenic Cell Death and Immunotherapy of Multiple Myeloma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019. DOI: 10.3389/fcell.2019.00306
  
  
• Gallego-Lleyda, A.; de Miguel, D.; Anel, A.; Martinez-Lostao, L. Lipid nanoparticles decorated with TNF-related aptosis-inducing ligand (TRAIL) are more cytotoxic than soluble recombinant TRAIL in sarcoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018. DOI: 10.3390/ijms19051449
  
  
• Sanchez-Martinez, D.; Allende-Vega, N.; Orecchioni, S.; Talarico, G.; Cornillon, A.; Vo, D.N.; Rene, C.; Lu, Z.Y.; Krzywinska, E.; Anel, A.; Galvez, E.M.; Pardo, J.; Robert, B.; Martineau, P.; Hicheri, Y.; Bertolini, F.; Cartron, G.; Villalba, M. Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors. THERANOSTICS. 2018. DOI: 10.7150/thno.25149
  
  
• Khan, A.U.H.; Allende-Vega, N.; Gitenay, D.; Garaude, J.; Vo, D.-N.; Belkhala, S.; Gerbal-Chaloin, S.; Gondeau, C.; Daujat-Chavanieu, M.; Delettre, C.; Orecchioni, S.; Talarico, G.; Bertolini, F.; Anel, A.; Cuezva, J.M.; Enriquez, J.A.; Cartron, G.; Lecellier, C.-H.; Hernandez, J.; Villalba, M. Mitochondrial complex I activity signals antioxidant response through ERK5. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). 2018. DOI: 10.1038/s41598-018-23884-4
  
  
• de Miguel, D.; Lemke, J.; Anel, A.; Walczak, H.; Martinez-Lostao, L. Onto better TRAILs for cancer treatment. CELL DEATH AND DIFFERENTIATION. 2016. DOI: 10.1038/cdd.2015.174
  
  
• de Miguel,D.;Gallego-Lleyda,A.;Ayuso,J. M.;Erviti-Ardanaz,S.;Pazo-Cid,R.;del Agua,C.;Fernández,L. J.;Ochoa,I.;Anel,A.;Martinez-Lostao,L. TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells. NANOTECHNOLOGY. 2016. DOI: 10.1088/0957-4484/27/18/185101
  
  
• Jarauta, V.;Jaime, P.;Gonzalo, O.;de Miguel, D.;Ramírez-Labrada, A.;Martínez-Lostao, L.;Anel, A.;Pardo, J.;Marzo, I.;Naval, J. Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. CANCER LETTERS. 2016. DOI: 10.1016/j.canlet.2016.08.019
  
  
• Bosque, A.; Dietz, L.; Gallego-Lleyda, A.; Sanclemente, M.; Iturralde, M.; Naval, J.; Alava, M.A.; Martínez-Lostao, L; Thierse, H.J.; Anel, A. Comparative proteomics of exosomes secreted by tumoral jurkat t cells and normal human t cell blasts unravels a potential tumorigenic role for valosin-containing protein. ONCOTARGET. 2016. DOI: 10.18632/oncotarget.8678
  
  
• Miguel, D. De; Gallego-Lleyda, A.; Ayuso, J. M.; Pejenaute-Ochoa, D.; Jarauta, V.; Marzo, I.; Fernández, L. J.; Ochoa, I.; Conde, B.; Anel, A.; Martinez-Lostao, L. High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer. CANCER LETTERS. 2016. DOI: 10.1016/j.canlet.2016.10.005
  
  
• Klionsky, Dj; Abdelmohsen, K; Abe, A; Abedin, Mj; Abeliovich, H; Acevedo Arozena, A; Adachi, H; Adams, Cm; Adams, Pd; Adeli, K; Adhihetty, Pj; Adler, Sg; Agam, G; Agarwal, R; Aghi, Mk; Agnello, M; Agostinis, P; Aguilar, Pv; Aguirre-Ghiso J; Airoldi, Em; Anel, A; Pardo, J. Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition). AUTOPHAGY. 2016
  
  
• de Miguel, D.; Gallego-Lleyda, A.; Ayuso, J. M.; Pawlak, A.; Conde, B.; Ochoa, I.; Fernández, L. J.; Anel, A.; Martinez-Lostao, L. Improved anti-tumor activity of novel highly bioactive liposome-bound TRAIL in breast cancer cells. RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. 2016. DOI: 10.2174/1574892811666160229121544
  
  
• Sánchez-Martínez, D.; Lanuza, P.M.; Gómez, N.; Muntasell, A.; Cisneros, E.; Moraru, M.; Azaceta, G.; Anel, A.; Martínez-Lostao, L.; Villalba, M.; Palomera, L.; Vilches, C.; García Marco, J.A.; Pardo, J. Activated allogeneic NK cells preferentially kill poor prognosis B-cell chronic lymphocytic leukemia cells. FRONTIERS IN IMMUNOLOGY. 2016. DOI: 10.3389/fimmu.2016.00454
  
  
• Martinez-Lostao, L.; Miguel, D. D.; Al-Wasaby, S.; Gallego-Lleyda, A.; Anel, A. Death ligands and granulysin: Mechanisms of tumor cell death induction and therapeutic opportunities. IMMUNOTHERAPY. 2015. DOI: 10.2217/imt.15.56
  
  
• Sanchez-Martínez, D; Azaceta, G; Muntasell, A; Aguiló, N; Núñez, D; Gálvez, Em; Naval, J; Anel, A; Palomera, L; Vilches, C;Marzo, I; Villalba, M; Pardo, J. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in hematological cancer cells. ONCOIMMUNOLOGY. 2015. DOI: 10.4161/2162402X.2014.991613
  
  
• Catalán, E.; Charni, S.; Jaime, P.; Aguiló, J. I.; Enríquez, J. A.; Naval, J.; Pardo, J.; Villalba, M.; Anel, A. MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells. ONCOIMMUNOLOGY. 2015. DOI: 10.4161/2162402X.2014.985924
  
  
• Martinez-Lostao, L; Anel, A; Pardo, J. How Do Cytotoxic Lymphocytes Kill Cancer Cells?. CLINICAL CANCER RESEARCH. 2015. DOI: 10.1158/1078-0432.CCR-15-0685
  
  
• de Miguel, D.;Gallego-Lleyda, A.;Anel, A.;Martinez-Lostao, L. Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells. LEUKEMIA RESEARCH. 2015. DOI: 10.1016/j.leukres.2015.03.019
  
  
• Anel, A.; Martínez-Lostao, L.; Pardo, J. Second meeting of the Spanish immunotherapy group GEIT (grupo español de inmunoterapia), january 16, 2015, in Zaragoza, Spain. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2015. DOI: 10.1007/s00262-015-1732-2
  
  
• Al-Wasaby, S.; de Miguel, D.; Aporta, A.; Naval, J.; Conde, B.; Martínez-Lostao, L.; Anel, A. In vivo potential of recombinant granulysin against human tumors. ONCOIMMUNOLOGY. 2015. DOI: 10.1080/2162402X.2015.1036213
  
  
• Ruiz-Garcia, R.; Mora, S.; Lozano-Sanchez, G.; Martinez-Lostao, L.; Paz-Artal, E.; Ruiz-Contreras, J.; Anel, A.; Gonzalez-Granado, L.; Moreno-Perez, D.; Allende, L. M. Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation. PEDIATRIC RESEARCH. 2015. DOI: 10.1038/pr.2015.170
  
  
• de Miguel, D.; Gallego-Lleyda, A.; Galan-Malo, P.; Rodriguez-Vigil, C.; Marzo, I.; Anel, A.; Martinez-Lostao, L. Immunotherapy with liposome-bound TRAIL overcomes partial protection to soluble TRAIL-induced apoptosis offered by down-regulation of Bim in leukemic cells. CLINICAL AND TRANSLATIONAL ONCOLOGY. 2015. DOI: 10.1007/s12094-015-1295-x
  
  
• Ramirez-Labrada, A; Lopez-Royuela, N; Jarauta, V; Galan-Malo, P; Azaceta, G; Palomera, L; Pardo, J; Anel, A; Marzo, I; Naval, J. Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis. CLINICAL AND TRANSLATIONAL ONCOLOGY. 2015. DOI: 10.1007/s12094-014-1201-y
  
  
• Aporta, A; Catalán, E; Galán-Malo, P; Ramírez-Labrada, A; Pérez, M; Azaceta, G; Palomera, L; Naval, J; Marzo, I; Pardo, J; Anel, A . Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. BIOCHEMICAL PHARMACOLOGY. 2014. DOI: 10.1016/j.bcp.2013.11.004
  
  
• Ruiz-García, Raquel; Lermo-Rojo, Sara; Martínez-Lostao, Luis; Mancebo, Esther; Mora-Díaz, Sergio; Paz-Artal, Estela; Ruiz-Contreras, Jesus; Anel, Alberto; González-Granado, Luis I; Allende, Luis M. A case of partial dedicator of cytokinesis 8 deficiency with altered effector phenotype and impaired CD8+ and natural killer cell cytotoxicity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014. DOI: 10.1016/j.jaci.2014.01.023
  
  
• Sanchez-Martínez, Diego; Krzywinska, Ewelina; Rathore, Moeez G.; Saumet, Anne; Cornillon, Amelie; Lopez-Royuela, Nuria; Martínez-Lostao, Luis; Ramirez-Labrada, Ariel; Lu, Zhao-Yang; Rossi, Jean-François; Fernández-Orth, Dietmar; Escorza, Sergio; Anel, Alberto; Lecellier, Charles-Henri; Pardo, Julian; Villalba, Martin. All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2014. DOI: 10.1016/j.biocel.2014.01.003
  
  
• Comet, Nr; Aguilo, Ji; Rathore, Mg; Catalán, E; Garaude, J; Uze, G; Naval, J; Pardo, J; Villalba, M; Anel, A. IFN-a signaling through PKC-Thetha is essential for anti-tumoral NK cell function. ONCOIMMUNOLOGY. 2014. DOI: 10.4161/21624011.2014.948705
  
  
• de Miguel, D.; Basáñez, G.; Sánchez, D.; Galán-Malo, P.; Marzo, I.; Larrad, L.; Naval, J.; Pardo, J.; Anel, A.; Martinez Lostao, L. Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells. MOLECULAR PHARMACEUTICS. 2013. DOI: 10.1021/mp300258c
  
  
• Martinez Lostao, Luis; Anel, Alberto; Regner, Mathias; Froelich, Christopher J; Pardo, Julián. Immunological Cytotoxic Factors. THE ENCYCLOPEDIA OF LIFE SCIENCES. 2013. DOI: 10.1002/9780470015902.a0000928.pub3
  
  
• Aguilo, Ji; Alonso, H; Uranga, S; Marinova, D; Arbués, A; de Martino, A; Anel, A; Monzon, M; Badiola, J; Pardo, J; Brosch, R; Martin, C . ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis. CELLULAR MICROBIOLOGY. 2013. DOI: 10.1111/cmi.12169
  
  
• Morales, A; Catalan, E; Hervas, S; Palazon, A; Azpilikueta, A; Bolaños, E; Anel, A; Pardo, J*; Melero, I* . Essential complicity of perf/granzyme and FAS-L mechanisms to achieve tumor rejection after treatment with anti-CD137 mAb. JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2013. DOI: 10.1186/2051-1426-1-3
  
  
• Aporta,A.;Arbues,A.;Aguilo,J. I.;Monzon,M.;Badiola,J. J.;de Martino,A.;Ferrer,N.;Marinova,D.;Anel,A.;Martin,C.;Pardo,J. Attenuated Mycobacterium tuberculosis SO2 Vaccine Candidate Is Unable to Induce Cell Death. PLOS ONE. 2012. DOI: 10.1371/journal.pone.0045213
  
  
• Martinez-Lostao, L.; Anel, A. Role of Apo2L/TRAIL in immunity: Applications to rheumatoid arthritis. WORLD JOURNAL OF RHEUMATOLOGY. 2012. DOI: 10.5499/wjr.v2.i1.1
  
  
• Pazo Cid, R.A; Álvarez Alejandro, M.; Cebollero de Miguel, A.; Agustín, M.J.; Martinez-Lostao, L.; Anel Bernal, A.; Pérez Gracia, J.L.; Antón Torres, A. Apoptosis, cáncer & Co. REVISTA INTERNACIONAL DE GRUPOS DE INVESTIGACIÓN EN ONCOLOGÍA. 2012
  
  
• Anel, A.; Aguiló, J.I.; Catalán, E.; Garaude, J.; Rathore, M.G.; Pardo, J.; Villalba, M. Protein kinase C-0 (PKC-0) in natural killer cell function and anti-tumor immunity. FRONTIERS IN IMMUNOLOGY. 2012. DOI: 10.3389/fimmu.2012.00187
  
  
• Martinez-Lostao,L.;Marzo,I.;Anel,A.;Naval,J. Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer. BIOCHEMICAL PHARMACOLOGY. 2012. DOI: 10.1016/j.bcp.2011.12.036
  
  
• Aguiló,Juan Ignacio; Iturralde,María; Monleón,Inmaculada.; Iñarrea,Pedro; Pardo,Julián; Martínez-Lorenzo, María José; Anel, Alberto; Alava,María Ángeles. Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: Reactive oxygen species generation and inactive shortened SOD1 isoform implications. CHEMICO-BIOLOGICAL INTERACTIONS. 2012. DOI: 10.1016/j.cbi.2012.05.001
  
  
• Anel,A.;Martinez-Lostao,L. Apo2l/trail: New insights in the treatment of autoimmune disorders. RECENT PATENTS ON INFLAMMATION AND ALLERGY DRUG DISCOVERY. 2011. DOI: 10.2174/187221311797264883
  
  
• Bernardo,I.;Mancebo,E.;Aguiló,I.;Anel,A.;Allende,L. M.;Guerra-Vales,J.;Ruiz-Contreras,J.;Serrano,A.;Talayero,P.;De,La Calle;Gonzalez-Santesteban,C.;Paz-Artal,E. Phenotypic and functional evaluation of CD3+CD4-CD8-T cells in human cd8 immunodeficiency. HAEMATOLOGICA. 2011. DOI: 10.3324/haematol.2011.041301
  
  
• Aguilo, J. I.;Anel, A.;Catalan, E.;Sebastian, A.;Acin-Perez, R.;Naval, J.;Wallich, R.;Simon, M. M. ;Pardo, J. Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation. IMMUNOLOGY AND CELL BIOLOGY. 2010
  
  
• Martinez-Lostao, L.; Garcia-Alvarez, F.; Basanez, G.; Alegre-Aguaron, E.; Desportes, P.; Larrad, L.; Naval, J.; Martinez-Lorenzo, M. J.; Anel, A. Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis. ARTHRITIS AND RHEUMATISM. 2010. DOI: 10.1002/art.27501
  
  
• López-Royuela, Nuria; Pérez-Galán, Patricia; Galán-Malo, Patricia; Yuste, Victor J.; Anel, Alberto; Susín, Santos A.; Naval, Javier; Marzo, Isabel. Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells. BIOCHEMICAL PHARMACOLOGY. 2010. DOI: 10.1016/j.bcp.2010.02.010
  
  
• López-Royuela, Nuria; Balsas, Patricia; Galán-Malo, Patricia; Anel, Alberto; Marzo, Isabel; Naval, Javier. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR CELL RESEARCH. 2010. DOI: 10.1016/j.bbamcr.2009.11.004
  
  
• Charni, S.;de Bettignies, G.;Rathore, M. G.;Aguilo, J. I.;Van, Den E.;Haouzi, D.;Hipskind, R. A.;Enriquez, J. A.;Sanchez-Beato, M.;Pardo, J.;Anel, A. ;Villalba, M. Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway. THE JOURNAL OF IMMUNOLOGY. 2010. DOI: 10.4049/jimmunol.1001250
  
  
• Anel, A.;Bleackley, C.;Borner, C.;Golstein, P.;Krammer, P. H.;Muellbacher, A.;Pardo, J.;Simon, M. M.;Trapani, J. A. EMBO Workshop on Cytotoxicity, Cell Death and the Immune System. CELL DEATH AND DIFFERENTIATION. 2009
  
  
• Charni, S;Aguilo, J.I;Garaude, J;de Bettignies, G;Jacquet, C;Hipskind, R.A;Singer, D;Anel, A;Villalba, M. ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels that Activate NK Cells and Block Tumorigenesis. THE JOURNAL OF IMMUNOLOGY. 2009
  
  
• Balsas, Patricia; López-Royuela, Nuria; Galán-Malo, Patricia; Anel, Alberto; Marzo, Isabel; Naval, Javier. Cooperation between Apo2LTRAIL and bortezomib in multiple myeloma apoptosis. BIOCHEMICAL PHARMACOLOGY. 2009. DOI: 10.1016/j.bcp.2008.11.024
  
  
• Pardo, J;Aguilo, J.I;Anel, A;Martin, P;Joeckel, L;Borner, C;Wallich, R;Muellbacher, A;Froelich, C.J;Simon, M.M. The Biology of Cytotoxic Cell Granule Exocytosis Pathway: Granzymes have Evolved to Induce Cell Death and Inflammation. MICROBES AND INFECTION. 2009
  
  
• Aguilo, J. I.;Garaude,J.;Pardo,J.;Villalba,M.;Anel,A. Protein Kinase C-Theta is Required for NK Cell Activation and in Vivo Control of Tumor Progression. THE JOURNAL OF IMMUNOLOGY. 2009
  
  
• Dietz, L.;Bosque,A.;Pankert,P.;Ohnesorge,S.;Merz,P.;Anel,A.;Schnoelzer,M.;Thierse,H. Quantitative DY-Maleimide-Based Proteomic 2-DE-Labeling Strategies using Human Skin Proteins. PROTEOMICS. 2009
  
  
• Bosque, A.;Aguilo,J. I.;del Rey,M.;Paz-Artal,E.;Allende,L. M.;Naval,J.;Anel,A. Cell Cycle Regulation by FasL and Apo2L/TRAIL in Human T-Cell Blasts. Implications for Autoimmune Lymphoproliferative Syndromes. JOURNAL OF LEUKOCYTE BIOLOGY. 2008
  
  
• Garaude, J; Kaminski, S; Charni, S; Aguiló, Ji; Jacquet, C; Plays, M; Hernandez, J; Rodriguez, F; Hipskind, Ra; Anel, A; Villalba, M. Impaired anti-leukemic immune response in PKCtheta-deficient mice. MOLECULAR IMMUNOLOGY. 2008. DOI: 10.1016/j.molimm.2008.03.016
  
  
• Bosque, A.;Aguilo,J. I.;Alava,M. A.;Paz-Artal,E.;Naval,J.;Allende,L. M.;Anel,A. The Induction of Bim Expression in Human T-Cell Blasts is Dependent on Nonapoptotic Fas/CD95 Signaling. BLOOD. 2007
  
  
• Bosque, Alberto; Marzo, Isabel; Naval, Javier; Anel, Alberto. Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss. MOLECULAR IMMUNOLOGY. 2007. DOI: 10.1016/j.molimm.2006.04.029
  
  
• Del-Rey, Mj; Manzanares, J; Bosque, A; Aguiló, Ji; Gómez-Rial, J; Roldan, E; Serrano, A; Anel, A; Paz-Artal, E; Allende, Lm. Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation. IMMUNOBIOLOGY. 2007
  
  
• Anel, A; Bosque, A; Naval, J; Pineiro, A; Larrad, L; Alava, Ma; Martinez Lorenzo, Mj. Apo2L/TRAIL and immune regulation. FRONTIERS IN BIOSCIENCE (ELITE EDITION). 2007
  
  
• Gómez-Benito, Maria; Martinez-Lorenzo, Maria José; Anel, Alberto; Marzo, Isabel; Naval, Javier. Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2LTRAIL. EXPERIMENTAL CELL RESEARCH. 2007. DOI: 10.1016/j.yexcr.2007.03.018
  
  
• Gómez-Benito, Maria; Balsas, Patricia; Carvajal-Vergara, Xonia; Pandiella, Atanasio; Anel, Alberto; Marzo, Isabel; Naval, Javier. Mechanism of apoptosis induced by IFN-a in human myeloma cells: Role of Jak1 and Bim and potentiation by rapamycin. CELLULAR SIGNALLING. 2007. DOI: 10.1016/j.cellsig.2006.10.009
  
  
• Martinez-Lorenzo, M. J.;Anel, A.;Saez-Gutierrez, B.;Royo-Canas, M.;Bosque, A.;Alava, M. A.;Pineiro, A.;Lasierra, P.;Asin-Ungria, J.;Larrad, L. Rheumatoid Synovial Fluid T Cells are Sensitive to APO2L/TRAIL. CLINICAL INMUNOLOGY. 2007
  
  
• Pardo,J.;Urban,C.;Bosque,A.;Anel,A.;Wallich,R.;Muellbacher,A.;Borner,C.;Simon,M. M. Mitochondria mediate host and pathogen induced apoptosis. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2006
  
  
• Diestre,C.;Martinez-Lorenzo,M. J.;Bosque,A.;Naval,J.;Larrad,L.;Anel,A. Generation of rabbit antibodies against death ligands by cDNA immunization. JOURNAL OF IMMUNOLOGICAL METHODS. 2006
  
  
• Martinez-Lorenzo, M.J;Anel, A;Saez-Gutierrez, B;Royo-Canas, M;Bosque, A;Alava, M.A;Pineiro, A;Lasierra, P;Asin-Ungria, J;Larrad, L. Rheumatoid synovial fluid T cells are sensitive to APO2L. THE JOURNAL OF IMMUNOLOGY. 2006
  
  
• Gómez-Benito, Maria; Balsas, Patricia; Bosque, Alberto; Anel, Alberto; Marzo, Isabel; Naval, Javier. Apo2LTRAIL is an indirect mediator of apoptosis induced by interferon-a in human myeloma cells. FEBS LETTERS. 2005. DOI: 10.1016/j.febslet.2005.10.007
  
  
• Bosque, Alberto; Pardo, Julián; Martínez-Lorenzo, María José; Lasierra, Pilar; Larrad, Luis; Marzo, Isabel; Naval, Javier; Anel, Alberto. Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL. EUROPEAN JOURNAL OF IMMUNOLOGY. 2005. DOI: 10.1002/eji.200526046
  
  
• Gómez-Benito, María; Marzo, Isabel; Anel, Alberto; Naval, Javier. Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination. MOLECULAR PHARMACOLOGY. 2005. DOI: 10.1124/mol.104.007021
  
  
• Bosque, Alberto; Pardo, Julián; Martínez-Lorenzo, M\u00aa José; Iturralde, María; Marzo, Isabel; Piñeiro, Andrés; Alava, M\u00aa Angeles; Naval, Javier; Anel, Alberto. Down-regulation of normal human T cell blast activation: roles of APO2LTRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression. JOURNAL OF LEUKOCYTE BIOLOGY. 2005. DOI: 10.1189/jlb.0904514
  
  
• Martin Fernandez, J.M;Cabanillas, J.A;Rivero Carmena, M;Lacasa, E;Pardo, J;Anel, A;Ramirez Duque, P.R;Merino, F;Rodriguez Gallego, C;Regueiro, J.R. Herpesvirus Saimiri-Transformed Cd8(+) T Cells as a Tool to Study Chediak-Higashi Syndrome Cytolytic Lymphocytes. JOURNAL OF LEUKOCYTE BIOLOGY. 2005
  
  
• Iturralde, M.;Pardo, J.;Lacasa, E.;Barrio, G.;Alava, M. A.;Pineiro, A.;Naval, J.;Anel, A. Characterization of the Lipolytic Pathways That Mediate Free Fatty Acid Release During Fas/Cd95-Induced Apoptosis. APOPTOSIS. 2005
  
  
• Marzo, I; Pérez-Galán, P; Giraldo, P; López-Royuela, N; Gómez-Benito, M; Larrad, L; Lasierra, P; Rubio-Félix, D; Anel, A; Naval, J. Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. LEUKEMIA. 2004. DOI: 10.1038/sj.leu.2403469
  
  
• Pardo, J.;Bosque, A.;Brehm, R.;Wallich, R.;Naval, J.;Mullbacher, A.;Anel, A.;Simon, M. M. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. JOURNAL OF CELL BIOLOGY. 2004
  
  
• Pardo, J.;Buferne, M.;Martinez-Lorenzo, M. J.;Naval, J.;Schmitt-Verhulst, A. M.;Boyer, C.;Anel, A. Differential Implication of Protein Kinase C Isoforms in Cytotoxic T Lymphocyte Degranulation and Tcr-Induced Fas Ligand Expression. INTERNATIONAL IMMUNOLOGY. 2003
  
  
• Iturralde, M.;Gamen, S.;Pardo, J.;Bosque, A.;Pineiro, A.;Alava, M. A.;Naval, J.;Anel, A. Saturated Free Fatty Acid Release and Intracellular Ceramide Generation During Apoptosis Induction Are Closely Related Processes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2003
  
  
• Pardo, Julian;Balkow, Sandra;Anel, Alberto;Simon, Markus, M. The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells. EUROPEAN JOURNAL OF IMMUNOLOGY. 2002
  
  
• Monleon, I.;Iturralde, M.;Martinez Lorenzo, M. J;Monteagudo, L.;Lasierra, P.;Larrad, L.;Pineiro, A.;Naval, J.;Alava, M. A;Anel, A. . Lack of Fas/CD95 surface expression in highly proliferative leukemic cell lines correlates with loss of CtBP/BARS and redirection of the protein toward giant lysosomal structures. CELL GROWTH & DIFFERENTIATION. 2002
  
  
• Pardo, J. ;Balkow, S. ;Anel, A. ;Simon, M. M. Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control. EUROPEAN JOURNAL OF IMMUNOLOGY. 2002. DOI: 10.1002/1521-4141(2002010)32:10
  
  
• Monleon, I.;Martinez Lorenzo, M. J.;Monteagudo, L.;Lasierra, P.;Taules, M.;Iturralde, M.;Pineiro, A.;Larrad, L.;Alava, M. A.;Naval, J.;Anel, A. Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. THE JOURNAL OF IMMUNOLOGY. 2001
  
  
• Pardo, Julián; Pérez-Galán, Patricia; Gamen, Susana; Marzo, Isabel; Monleón, Inmaculada; Kaspar, Allan A.; Susín, Santos A.; Kroemer, Guido; Krensky, Alan M.; Naval, Javier; Anel, Alberto. A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis. THE JOURNAL OF IMMUNOLOGY. 2001. DOI: 10.4049/jimmunol.167.3.1222
  
  
• Gonzalez, B. ;Iturralde, M. ;Alava, M. A;Anel, A. ;Pineiro, A. Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2000
  
  
• Gamen, S.;Anel, A.;Perez Galan, P.;Lasierra, P.;Johnson, D.;Pineiro, A.;Naval, J. Doxorubicin Treatment Activates a Z-Vad-Sensitive Caspase, Which Causes Delta-Psi(M) Loss, Caspase-9 Activity, and Apoptosis in Jurkat Cells. EXPERIMENTAL CELL RESEARCH. 2000
  
  
• Martinez Lorenzo, M. J;Anel, A.;Monleon, I.;Sierra, J. J;Pineiro, A.;Naval, J.;Alava, M. A. Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2000
  
  
• Monleon, I.;Martinez Lorenzo, M. J;Anel, A.;Lasierra, P.;Larrad, L.;Pineiro, A.;Naval, J.;Alava, M. A. CD59 cross-linking induces secretion of APO2 ligand in overactivated human T cells. EUROPEAN JOURNAL OF IMMUNOLOGY. 2000
  
  
• Martinez-Lorenzo, M. J.;Anel, A.;Gamen, S.;Monle, N. I.;Lasierra, P.;Larrad, L.;Pineiro, A.;Alava, M. A.;Naval, J. Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles. THE JOURNAL OF IMMUNOLOGY. 1999
  
  
• Gamen, S.;Anel, A.;Pineiro, A.;Naval, J. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. CELL DEATH AND DIFFERENTIATION. 1998
  
  
• Gamen, S.;Hanson, D. A.;Kaspar, A.;Naval, J.;Krensky, A. M.;Anel, A. Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. THE JOURNAL OF IMMUNOLOGY. 1998
  
  
• Martinez-Lorenzo, M. J.;Alava, M. A.;Gamen, S.;Kim, K. J.;Chuntharapai, A.;Pineiro, A.;Naval, J.;Anel, A. Involvement of APO2 ligand TRAIL in activation-induced death of Jurkat and human peripheral blood T cells. EUROPEAN JOURNAL OF IMMUNOLOGY. 1998
  
  
• Martinez-Lorenzo, M. J.;Gamen, S.;Etxeberria, J.;Lasierra, P.;Larrad, L.;Pineiro, A.;Anel, A.;Naval, J.;Alava, M. A. Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells. INTERNATIONAL JOURNAL OF CANCER. 1998
  
  
• Gamen, S.;Anel, A.;Lasierra, P.;Alava, M. A.;Martinezlorenzo, M. J.;Piñeiro, A.;Naval, J. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS LETTERS. 1997
  
  
• Anel, A.;Martinez Lorenzo, M. J.;Schmitt Verhulst, A. M.;Boyer, C. Influence on CD8 of TCR. THE JOURNAL OF IMMUNOLOGY. 1997
  
  
• Anel, A.;Gamen, S.;Alava, M. A.;Schmittverhulst, A. M.;Piñeiro, A.;Naval, J. Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones. THE JOURNAL OF IMMUNOLOGY. 1997
  
  
• Martinezlorenzo, M. J.;Alava, M. A.;Anel, A.;Pineiro, A.;Naval, J. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. IMMUNOLOGY. 1996
  
  
• Gamen, Susana; Marzo, Isabel; Anel, Alberto; Piñeiro, Andrés; Naval, Javier. CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells. FEBS LETTERS. 1996. DOI: 10.1016/0014-5793(96)00666-7
  
  
• Anel, A.;Gamen, S.;Alava, M. A.;Schmittverhulst, A. M.;Piñeiro, A.;Naval, J. Role of oxidative damage and IL-1 beta-converting enzyme-like proteases in Fas-based cytotoxicity exerted by effector T cells. INTERNATIONAL IMMUNOLOGY. 1996
  
  
• Marzo, Isabel; Martínez-Lorenzo, María J.; Anel, Alberto; Desportes, Paula; Alava, María A.; Naval, Javier; Piñeiro, Andrés. Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - LIPIDS AND LIPID METABOLISM. 1995. DOI: 10.1016/0005-2760(95)00064-J
  
  
• Gamen, Susana; Anel, Alberto; Montoya, Julio; Marzo, Isabel; Piñeiro, Andrés; Naval, Javier. mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytototxicity. FEBS LETTERS. 1995. DOI: 10.1016/0014-5793(95)01236-1
  
  
• Uriel, J.;Torres, J. M.;Anel, A. Carrier-Protein-Mediated Enhancement of Fatty-Acid-Binding and Internalization in Human T-Lymphocytes. BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR CELL RESEARCH. 1994
  
  
• Torres, J. M.;Anel, A.;Uriel, J. Alpha-Fetoprotein-Mediated Uptake of Fatty-Acids by Human Lymphocytes-T. JOURNAL OF CELLULAR PHYSIOLOGY. 1992
  
  
• Anel, A.; Naval, J.; Desportes, P.; Gonzalez, B.; Uriel, J.; Piñeiro, A. Increased cytotoxicity of polyunsaturated fatty acids on human tumoral B and T-cell lines compared with normal lymphocytes. LEUKEMIA. 1992
  
  
• Iturralde, M.;Alava, M. A.;Gonzalez, B.;Anel, A.;Piñeiro, A. Effect of Alpha-Fetoprotein and Albumin on the Uptake of Polyunsaturated Fatty-Acids by Rat Hepatoma-Cells and Fetal-Rat Hepatocytes. BIOCHIMICA ET BIOPHYSICA ACTA. 1991
  
  
• Aguilar, J. J.;Anel, A.;Torres, J. M.;Semmel, M.;Uriel, J. Changes in Lipid-Composition of Human Peripheral-Blood Lymphocytes Infected by Hiv. AIDS RESEARCH AND HUMAN RETROVIRUSES. 1991
  
  
• Anel, A.;Halmos, T.;Torres, J. M.;Piñeiro, A.;Antonakis, K.;Uriel, J. Cytotoxicity of Chlorambucil and Chlorambucil Fatty-Acid Conjugates Against Human Lymphomas and Normal Human Peripheral-Blood Lymphocytes. BIOCHEMICAL PHARMACOLOGY. 1990
  
  
• Anel, A.;Naval, J.;Gonzalez, B.;Torres, J. M.;Mishal, Z.;Uriel, J.;Piñeiro, A. Fatty-Acid Metabolism in Human-Lymphocytes .1. Time-Course Changes in Fatty-Acid Composition and Membrane Fluidity during Blastic Transformation of Peripheral-Blood Lymphocytes. BIOCHIMICA ET BIOPHYSICA ACTA. 1990
  
  
• Anel, A.;Calvo, M.;Naval, J.;Iturralde, M.;Alava, M. A.;Piñeiro, A. Interaction of Rat Alpha-Fetoprotein and Albumin with Poly-Unsaturated and Other Fatty-Acids - Determination of Apparent Association Constants. FEBS LETTERS. 1989
  
  

Comunicaciones

• Soler, R.; Ames, T.; Marco-Brualla, J.; Moreno-Loshuertos, R.; Price, M.; Jimeno, J.; Anel, A. PT-112, a first-in-class pyrophosphate-platinum conjugate, selectively targets highly glycolytic tumor cells. EUROPEAN JOURNAL OF CANCER. 2020. DOI: 10.1016/S0959-8049(20)31219-3
  
  
• Reina-Ortiz, C.; Ewing, T.; Serrano del Valle, A.; Marco-Brualla, J.; Izquierdo, I.; Azaceta, G.; Palomera, L.; Marzo, I.; Naval, J.; Anel, A. Expansion of human NK cells for the treatment of multiple myeloma. CELL DEATH DISCOVERY. 2019. DOI: 10.1038/s41420-018-0128-4
  
  

Capítulos

• Generation of transmitochondrial cybrids in cancer cells. Soler-Agesta, Ruth; Ripollés-Yuba, Cristina; Marco-Brualla, Joaquín; Moreno-Loshuertos, Raquel; Sato, Ai; Beltrán-Visiedo, M.; Galluzzi, L.; Anel, Alberto. METHODS IN CELL BIOLOGY. ANIMAL MODELS OF DISEASE - PART B. 2024
  
  

Dirección de tesis

• Impact of mitochondrial function in the response of cancer cells to PT-112. Universidad de Zaragoza. Sobresaliente cum laude. 04/10/24
  
  
• Expanded Natural Killer cell-based therapy for hematological cancers. Inmunoterapia basada en células Natural Killer expandidas para canceres hematológicos. Universidad de Zaragoza. Sobresaliente cum laude. 04/07/24
  
  
• APROXIMACIONES DE INMUNOTERAPIA CONTRA EL MIELOMA MÚLTIPLE BASADAS EN LAS CÉLULAS NK-92: TRANSFECCIÓN ESTABLE CON CD16 Y GENERACIÓN DE UN NK-CAR ANTI-SLAMF7. Universidad de Zaragoza. Sobresaliente cum laude. 03/11/23
  
  
• INMUNOTOXINA ANTI-CEA BASADA EN LA GRANULISINA COMO UNA NUEVA TERAPIA ANTITUMORAL. Universidad de Zaragoza. Sobresaliente cum laude. 30/11/21
  
  
• EFECTO ANTITUMORAL DE INMUNOTOXINAS ANTI-TN CONJUGADAS CON GRANULISINA. Universidad de Zaragoza. Sobresaliente cum laude. 02/07/21
  
  
• Role of PknH in Mycobacterium tuberculosis Complex virulence. Involvement of lung myeloid cells in vaccine-induced protection of pulmonary delivered BCG. Universidad de Zaragoza. Sobresaliente cum laude. 03/09/20
  
  
• Metabolismo glucídico de los tumores y distintas aproximaciones de terapia antitumoral. Universidad de Zaragoza. Sobresaliente cum laude. 12/07/19
  
  
• Highly bioactive TRAIL formulations based on lipid nanoparticles. Universidad de Zaragoza. Sobresaliente cum laude. 13/11/15
  
  
• In vivo study of granulysin as a new immunotherapeutical agent against tumor development. Universidad de Zaragoza. Sobresaliente cum laude. 21/11/14
  
  
• Apoptosis como mecanismo de defensa ante situaciones patológicas endógenas (cáncer) y situaciones patológicas de origen externo (infección bacteriana por M. tuberculosis). Universidad de Zaragoza. Sobresaliente cum laude. 22/07/13
  
  
• Análisis de la contribución de los mecanismos efectores de las células citotóxicas en la inmunidad antitumoral. Universidad de Zaragoza. Sobresaliente cum laude. 19/07/13
  
  
• Mecanismos efectores y de activación de linfocitos T citotóxicos y células NK. Universidad de Zaragoza. Sobresaliente "Cum Laude". 27/05/09
  
  
• Caracterización de anticuerpos contra ligandos de la familia del TNF. Papel de Apo3L/TWEAK en la regulación de la respuesta antitumoral de las celulas NK. Universidad de Zaragoza. Sobresaliente "Cum Laude". 14/07/06
  
  
• Mecanismos de regulación de la activación de los linfocitos T humanos. Universidad de Zaragoza. Sobresaliente "Cum Laude". 24/02/06
  
  
• Mecanismos citoliticos de los linfocitos T citotoxicos: perforina/granzimas, granulisina e inducción de fasl. Universidad de Zaragoza. Sobresaliente "Cum Laude". 04/12/03
  
  
• Caracterización de los mecanismos de apoptosis inducida por los fármacos antitumorales doxorrubicina y cladribina en leucemias humanas. Universidad de Zaragoza. Sobresaliente "Cum Laude". 28/03/03
  
  
• Mecanismos implicados en la regulación homeostática y en la resistencia a la apoptosis de células T humanas normales y tumorales. Universidad de Zaragoza. Sobresaliente "Cum Laude". 08/04/02
  
  
• Mecanismos de muerte celular programada inducidas por proteínas producidas por células del sistema inmunitario. Universidad de Zaragoza. Sobresaliente "Cum Laude". 19/06/98
  
  

UNIZAR teaching of the last six courses

• Biotecnología de anticuerpos monoclonales aplicada a la inmunoterapia del cáncer. Máster Universitario en Inmunología Tumoral e Inmunoterapia del Cáncer. During academic year 2024-25
  
  
• Sistema inmune y cáncer. microambiente tumoral. Máster Universitario en Inmunología Tumoral e Inmunoterapia del Cáncer. From the 2022-23 course to the 2024-25 course
  
  
• Terapia celular adoptiva. Máster Universitario en Inmunología Tumoral e Inmunoterapia del Cáncer. From the 2022-23 course to the 2024-25 course
  
  
• Avances en patología molecular. Máster Universitario en Biología Molecular y Celular. From the 2019-20 course to the 2024-25 course
  
  
• Inmunología. Graduado en Biotecnología. From the 2019-20 course to the 2024-25 course
  
  
• Técnicas avanzadas en biología molecular y celular. Máster Universitario en Biología Molecular y Celular. From the 2019-20 course to the 2024-25 course
  
  
• Inmunología avanzada. Máster Universitario en Biología Molecular y Celular. From the 2019-20 course to the 2023-24 course
  
  
• Base molecular de la comunicación celular y el cáncer. Graduado en Biotecnología. From the 2019-20 course to the 2021-22 course