Perfil (CV) del personal docente investigador

Gonzalo Asensio, Jesús Ángel
Departamento: Departamento de Microbiología, Pediatría, Radiología y Salud Pública
Área: Microbiología
Centro: Facultad de Ciencias

Research Institute: INSTITUTO INVESTIGACIÓN SANITARIA DE ARAGÓN (IIS)
Grupo: B35_23R: Genética de micobacterias (GENMICO)

Códigos UNESCO
  • Bioquímica
  • Ingeniería genética
  • Microbiología
  • Biología molecular de microorganismos
Categoría profesional: Prof. Titular Univ.
Correo electrónico: jagonzal@unizar.es
ORCID: 0000-0001-8841-6593

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Artículos

  • Pérez, Irene; Uranga, Santiago; Sayes, Fadel; Frigui, Wafa; Samper, Sofía; Arbués, Ainhoa; Aguiló, Nacho; Brosch, Roland; Martín, Carlos; Gonzalo-Asensio, Jesús. Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential. EBIOMEDICINE. 2020. DOI: 10.1016/j.ebiom.2020.102761

  • Martin, Carlos; Aguilo, Nacho; Marinova, Dessislava; Gonzalo-Asensio, Jesús. Update on TB vaccine pipeline. APPLIED SCIENCES (SWITZERLAND). 2020. DOI: 10.3390/app10072632

  • Diaz, Caridad; Pérez del Palacio, José; Valero-Guillen, Pedro Luis; Mena Garcia, Patricia; Perez, Irene; Vicente, Francisca; Martin, Carlos; Genilloud, Olga; Sanchez Pozo, Antonio; Gonzalo-Asensio, Jesús. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS INFECTIOUS DISEASES. 2019. DOI: 10.1021/acsinfecdis.9b00008

  • Garmendia, Junkal; Gonzalo-Asensio, Jesús. Update on the Immune Mechanisms Against Respiratory Pathogens. FRONTIERS IN IMMUNOLOGY. 2019. DOI: 10.3389/fimmu.2019.01730

  • Broset, E.; Saubi, N.; Guitart, N.; Aguilo, N.; Uranga, S.; Kilpeläinen, A.; Eto, Y.; Hanke, T.; Gonzalo-Asensio, J.; Martín, C.; Joseph-Munné, J. MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2019. DOI: 10.1016/j.omtm.2019.01.014

  • Tameris, Michele; Mearns, Helen; Penn-Nicholson, Adam; Gregg, Yolande; Bilek, Nicole; Mabwe, Simbarashe; Geldenhuys, Hennie; Shenje, Justin; Luabeya, Angelique Kany K.; Murillo, Ingrid; Doce, Juana; Aguilo, Nacho; Marinova, Dessislava; Puentes, Eugenia; Rodríguez, Esteban; Gonzalo-Asensiom, Jesús; Fritzell, Bernard; Thole, Jelle; Martin, Carlos; Scriba, Thomas J.; Hatherill, Mark; Africa, Hadn; Arendsen, Denis; Botes, Natasja; Cloete, Yolundi; de Kock, Marwou; Erasmus, Margaret; Jack, Lungisa; Kafaar, Fazlin; Kalepu, Xoliswa; Khomba, Nondumiso Gloria; Kruger, Sandra; Leopeng, Thelma; Makhethe, Lebohang; Mouton, Angelique; Mulenga, Humphrey; Musvosvi, Munyaradzi; Noble, Julia; Opperman, Fajwa; Reid, Tim; Rossouw, Susan; Schreuder, Constance; Smit, Erica; Steyn, Marcia; Tyambethu, Petrus; Van Rooyen, Elma; Veldsman, Ashley; Mtbvac Clinical Trial Team. Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial. THE LANCET. RESPIRATORY MEDICINE. 2019. DOI: 10.1016/S2213-2600(19)30251-6

  • Martin, Carlos; Aguilo, Nacho; Gonzalo-Asensio, Jesús. Vacunación frente a tuberculosis. ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA. 2018. DOI: 10.1016/j.eimc.2018.02.006

  • Gonzalo-Asensio, J.; Pérez, I.; Aguiló, N.; Uranga, S.; Picó, A.; Lampreave, C.; Cebollada, A.; Otal, I.; Samper, S.; Martín, C. New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages. PLOS GENETICS. 2018. DOI: 10.1371/journal.pgen.1007282

  • Saubi, N.; Broset, E.; Guitart, N.; Aguilo, N.; Uranga, S.; Kilpelainen, A.; Eto, Y.; Hanke, T.; Gonzalo-Asensio, J.; Martin, C.; Joseph, J. Construction and Characterization of Recombinant MTBVAC. HIV, a New Live Attenuated Vaccine Against HIV and Tuberculosis. AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018

  • Marinova, Dessislava; Gonzalo-Asensio, Jesús; Aguiló, Nacho; Martín, Carlos. MTBVAC from discovery to clinical trials in tuberculosis-endemic countries. EXPERT REVIEW OF VACCINES. 2017. DOI: 10.1080/14760584.2017.1324303

  • Aguilo, Nacho; Gonzalo-Asensio, Jesús; Alvarez-Arguedas, Samuel; Marinova, Dessislava; Gomez, Ana Belen; Uranga, Santiago; Spallek, Ralf; Singh, Mahavir; Audran, Regine; Spertini, François; Martin, Carlos. Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis. NATURE COMMUNICATIONS. 2017. DOI: 10.1038/ncomms16085

  • Gonzalo-Asensio, Jesús; Aguilo, Nacho; Marinova, Dessislava; Martin, Carlos. Breaking transmission with vaccines: the case of tuberculosis. MICROBIOLOGY SPECTRUM. 2017. DOI: 10.1128/microbiolspec.MTBP-0001-2016

  • Gonzalo-Asensio, J.; Marinova, D.; Martin, C.; Aguilo, N. MTBVAC: Attenuating the human pathogen of tuberculosis (TB) toward a promising vaccine against the TB epidemic. FRONTIERS IN IMMUNOLOGY. 2017. DOI: 10.3389/fimmu.2017.01803

  • Broset, E.; Martín, C.; Gonzalo-Asensio, J. Evolutionary landscape of the mycobacterium tuberculosis complex from the viewpoint of phoPR: Implications for virulence regulation and application to vaccine development. MBIO. 2015. DOI: 10.1128/mBio.01289-15

  • Ortego,L.; Gonzalo-Asensio,J.; Laguna,A.; Villacampa,M. D.; Gimeno,M. C. (Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents. JOURNAL OF INORGANIC BIOCHEMISTRY. 2015. DOI: 10.1016/j.jinorgbio.2015.01.007

  • Solans, L.; Gonzalo-Asensio, J.; Sala, C.; Benjak, A.; Uplekar, S.; Rougemont, J.; Guilhot, C.; Malaga, W.; Martín, C.; Cole, S.T. The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis. PLOS PATHOGENS. 2014. DOI: 10.1371/journal.ppat.1004183

  • Gonzalo-Asensio, J.; Malaga, W.; Pawlik, A.; Astarie-Dequeker, C.; Passemar, C.; Moreau, F.; Laval, F.; Daffé, M.; Martin, C.; Brosch, R.; Guilhot, C. Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. DOI: 10.1073/pnas.1406693111

  • Solans, L.; Aguiló, N.; Samper, S.; Pawlik, A.; Frigui, W.; Martín, C.; Brosch, R.; Gonzalo-Asensio, J. A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component. INFECTION AND IMMNUNITY. 2014. DOI: 10.1128/IAI.01824-14

  • Marinova,D.; Gonzalo-Asensio,J.; Aguilo,N.; Martin,C. Recent developments in tuberculosis vaccines. EXPERT REVIEW OF VACCINES. 2013. DOI: 10.1586/14760584.2013.856765

  • Arbues, Ainhoa; Aguilo, Juan I.; Gonzalo-Asensio, Jesús; Marinova, Dessislava; Uranga, Santiago; Puentes, Eugenia; Fernández, Conchita; Parra, Alberto; Cardona, Pere Joan; Vilaplana, Cristina; Ausina, Vicente; Williams, Ann; Clark, Simon; Malaga, Wladimir; Guilhot, Christophe; Gicquel, Brigitte; Martin, Carlos. Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials. VACCINE. 2013. DOI: 10.1016/j.vaccine.2013.07.051

  • Ortega, A.;Gonzalo-Asensio, J.; García-del Portillo, F. Dynamics of Salmonella small RNA expression in non-growing bacteria located inside eukaryotic cells. RNA BIOLOGY. 2012. DOI: 10.4161/rna.19317

  • Sevilla, E.; Martín-Luna, B.; González, A.; Gonzalo-Asensio, Ja.; Peleato, Ml.; Fillat, Mf. Identification of three new antisense RNAs in the fur locus from unicellular cyanobacteria. MICROBIOLOGY (UNITED KINGDOM). 2011. DOI: 10.1099/mic.0.048231-0

  • Brodin, P.;Poquet, Y.;Levillain, F.;Peguillet, I.;Larrouy-Maumus, G.;Gilleron, M.;Ewann, F.;Christophe, T.;Fenistein, D.;Jang, J.;Jang, M. -.;Park, S. -.;Rauzier, J.;Carralot, J. -.;Shrimpton, R.;Genovesio, A.;Gonzalo-Asensio, J.;Puzo, G.;Martin, C.;Brosch, R.;Stewart, G. R.;Gicquel, B. ;Neyrolles, O. High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLOS PATHOGENS. 2010

  • Cardona, P. J.; Gonzalo Asensio, J.; Arbues, A.; Otal, I.; Lafoz, C.; Gil, O.; Caceres, N.; Ausina, V.; Gicquel, B.; Martin, C. Extended Safety Studies of the Attenuated Live Tuberculosis Vaccine SO2 Based on phoP Mutants. VACCINE. 2009. DOI: 10.1016/j.vaccine.2009.02.060

  • Chesne-Seck, Maire Laure; Barilone,Nathalie; Boudou,Frederic; Gonzalo-Asensio, Jesús ; Kolattukudy, Pappachan E.; Martín, Carlos; Cole, Stewart T.; Gicquel, Brigitte; Gopaul, Desmuckh N.; Jackson, Mary. A point mutation in the two-component regulador PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses in Mycobacterium tuberculosis H37Ra. JOURNAL OF BACTERIOLOGY. 2008. DOI: 10.1128/JB.01465-07

  • Gonzalo-Asensio, J.;Soto, C. Y.;Arbues, A.;Sancho, J.;Menendez, M. D. C.;Garcia, M. J.;Gicquel, B.;Martin, C. The Mycobacterium Tuberculosis phoPR Operon is Positively Autoregulated in the Virulent Strain H37Rv. JOURNAL OF BACTERIOLOGY. 2008

  • Asensio, J. A. G.;Arbues,A.;Perez,E.;Gicquel,B.;Martin,C. Live Tuberculosis Vaccines Based on phoP Mutants: A Step Towards Clinical Trials. EXPERT OPINION ON BIOLOGICAL THERAPY. 2008

  • Gonzalo-Asensio, J.;Mostowy, S.;Harders-Westerveen, J.;Huygen, K.;Hernandez-Pando, R.;Thole, J.;Behr, M.;Gicquel, B.;Martin, C. PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium Tuberculosis Virulence. PLOS ONE. 2008

  • Gonzalo Asensio, J.; Maia, C.; Ferrer, Nl.; Barilone, N.; Laval, F.; Soto, Cy.; Winter, N.; Daffé, M.; Gicquel, B.; Martín, C.; Jackson, M. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. DOI: 10.1074/jbc.C500388200

Comunicaciones

  • Saubi, N.; Broset, E.; Gonzalo-Asensio, J.; Guitart, N.; Hanke, T.; Marti´n, C.; Joseph, J. Pre-clinical development of MTBVAC.HIVA, a live- attenuated m. tuberculosis strain candidate for HIV-TB pediatric vaccine. ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA. 2016

Capítulos

  • Breaking Transmission with Vaccines: The Case of Tuberculosis. Jesús Gonzalo-Asensio; Nacho Aguilo; Dessislava Marinova; MICROBIAL TRANSMISSION. 2019

  • Adaptative Evolution of the Mycobacterium tuberculosis Complex to different hosts. Gonzalo Asensio, Jesús ; Broset, Esther. GENETICS AND EVOLUTION OF INFECTIOUS DISEASES. 2017

  • Adaptive Evolution of the Mycobacterium tuberculosis Complex to Different Hosts. Broset Blasco, Esther ; Gonzalo Asensio, Jesús Ángel. GENETICS AND EVOLUTION OF INFECTIOUS DISEASES. 2017

  • Importancia de la tuberculosis bovina en humanos: desde los datos epidemiológicos a la caracterización molecular (Capítulo 17). Gonzalo Asensio, Jesús Ángel ... [et al.]. TUBERCULOSIS ANIMAL: INVESTIGACIÓN Y CONTROL EN ESPAÑA. 2015

  • Los Retos de la Erradicacion de la Tuberculosis en el Siglo XXI. Gonzalo Asensio, Jesús Ángel ; Samper Blasco, Sofía ; Aínsa, José Antonio, Otal Gil, Isabel y Martín Montañés, Carlos. APLICACIÓN DE LA BIOTECNOLOGÍA EN LA CIENCIA VETERINARIA. 2012

  • ATTENUATED VACCINES (Chapter 13). Carlos Martín y Jesús Gonzalo-Asensio. THE ART AND SCIENCE OF TUBERCULOSIS VACCINE DEVELOPMENT. 2010



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